Rebecca Hommer's research while affiliated with National Institute of Mental Health (NIMH) and other places
What is this page?
This page lists the scientific contributions of an author, who either does not have a ResearchGate profile, or has not yet added these contributions to their profile.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
Publications (35)
The objective of this study is to examine the association between headache and mental disorders in a nationally representative sample of American youth. We used the National Comorbidity Survey–Adolescent Supplement to assess sex-specific prevalence of lifetime migraine and non-migraine headache using modified International Headache Society criteria...
Background
There is an epidemic of obesity in children and adolescents. Research into the self-regulatory factors that drive eating behavior is of critical importance. Food craving contributes to overeating and difficulty with weight loss and is strongly correlated with self-regulation. High-frequency heart rate variability (HF HRV) reflects parasy...
Movement, behavioral, and neuropsychiatric disorders in children have been linked to infections and a group of anti-neuronal autoantibodies, implying dopamine receptor-mediated encephalitis within the basal ganglia. The purpose of this study was to determine if anti-neuronal biomarkers, when used as a group, confirmed the acute disease in Sydenham...
More than half of all children diagnosed with autism spectrum disorder are prescribed psychotropic medication. This stands in contrast with the fact that there are no FDA-approved medications for the treatment of the core symptoms of ASD. ASD is commonly associated with challenging behaviors such as inattention, hyperactivity, irritability, aggress...
Background
We previously demonstrated the specificity of familial transmission of the atypical subtype of depression, primarily characterized by overeating and oversleeping. However, the specific components of this subtype that are familial have not been established. The aim of this paper is to examine whether the familial specificity of atypical d...
The Trier Social Stress Test for children (TSST-C) adapted from TSST is one of the most commonly used laboratory paradigms for investigating the effects of stress on cognitive, affective and physiological responses in children and adolescents. Considering that laboratory procedures generate a significant amount of stress to children and adolescents...
This comprehensive, 51-chapter handbook presents recent advances in the expression, etiology, assessment, and treatment of child and adolescent psychiatric disorders and related problems from a developmental psychopathology perspective. Following a broad conceptual overview of this area of clinical research and practice, assessment and treatment pr...
Little is known about the natural history of children with pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS). This study prospectively followed 33 children with PANDAS for up to 4.8 years (mean 3.3 ± 0.7 years) after enrollment in a 24-week randomized, double-blind, placebo-controlled trial of intraven...
Objective:
Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) are hypothesized to occur as a result of cross-reactive antibodies produced in response to group A streptococcal infections. Previous research suggests that immunomodulatory therapies, such as intravenous immunoglobulin (IVIG), may lead to...
Study objectives:
Polysomnographic investigation of sleep architecture in children presenting with pediatric acute-onset neuropsychiatric syndrome (PANS).
Methods:
Fifteen consecutive subjects meeting criteria for PANS (mean age = 7.2 y; range 3-10 y) underwent single-night full polysomnography (PSG) read by a pediatric neurologist.
Results:
T...
Background:
Few prospective studies examine the link between lower heart rate variability (HRV) and depression symptoms in adolescents. A recent animal model specifically links HRV to anhedonia, suggesting a potential translational model for human research.
Method:
We investigated the association between spectral measures of resting HRV and depr...
The first cases of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) were described>15 years ago. Since that time, the literature has been divided between studies that successfully demonstrate an etiologic relationship between Group A streptococcal (GAS) infections and childhood-onset obsessive-compul...
Background
Severe, chronic irritability is receiving increased research attention, and is the cardinal symptom of a new diagnostic category, disruptive mood dysregulation disorder (DMDD). Although data from epidemiological community samples suggest that childhood chronic irritability predicts unipolar depression and anxiety in adulthood, whether th...
Objective:
Sudden onset clinically significant eating restrictions are a defining feature of the clinical presentation of some of the cases of pediatric acute-onset neuropsychiatric syndrome (PANS). Restrictions in food intake are typically fueled by contamination fears; fears of choking, vomiting, or swallowing; and/or sensory issues, such as tex...
We used a dot-probe paradigm to examine attention bias toward threat (i.e., angry) and happy face stimuli in severe mood dysregulation (SMD) versus healthy comparison (HC) youth. The tendency to allocate attention to threat is well established in anxiety and other disorders of negative affect. SMD is characterized by the negative affect of irritabi...
Purpose:
Although talking to youth about drugs is often recommended to parents, we know little about how parents actually discuss drugs with their children in the moment and how parental advice is linked to youth arousal and substance use. This study examined observed parental drug use advice and parenting behaviors during parent-adolescent drug u...
We examined event-related electroencephalography (EEG) oscillations, including event-related spectral perturbations (ERSP) and intertrial coherence (ITC), to compare feedback processing during a chance-based reward vs. non-reward task in groups of 10-12-year-old (n=42), 13-14-year-old (n=34) and 15-17-year-olds (n=32). Because few, if any studies h...
We employed event-related potentials to examine the feedback-related negativity (FRN), during a non-learning reward versus non-reward task. We compared 10-12-year-old, 13-14-year-old, and 15-17-year-old youth (n = 91). Age effects included a larger FRN for younger age groups, regardless of feedback type, and a decrease in peak latency for feedback,...
Adolescence is a critical period of neurodevelopment for stress and appetitive processing, as well as a time of increased vulnerability to stress and engagement in risky behaviors. This study was conducted to examine brain activation patterns during stress and favorite-food-cue experiences relative to a neutral-relaxing condition in adolescents. Fu...
One important factor in adolescents' development of problem alcohol use is their family environment. Yet, the mechanisms that relate parenting to youth alcohol use are not well characterized. This study employed a naturalistic laboratory-based approach to observe parenting behaviors (support, structure, criticism) and adolescents' physiological and...
While much is known about the neural regions recruited in the human brain when a dominant motor response becomes inappropriate and must be stopped, less is known about the regions that support switching to a new, appropriate, response. Using functional magnetic resonance imaging with two variants of the stop-signal paradigm that require either stop...
Previous studies have indicated abnormalities in response flexibility in pediatric bipolar disorder (BD). Dysfunction in response flexibility may contribute to the pattern of behavioral and emotional dysregulation that is characteristic of BD, since depressed and manic patients respond inflexibly to emotional stimuli (i.e., anhedonia in the case of...
Reflecting a paradigm shift in clinical neuroscience, many chronic psychiatric illnesses are now hypothesized to result from perturbed neural development. However, most work in this area focuses on schizophrenia. Here, we extend this paradigm to pediatric bipolar disorder (BD), thus demonstrating traction in the developmental psychobiology perspect...
Citations
... Migraine is frequently associated with symptoms of anxiety and/or depression (reviewed in [40,41]). This association is reported as bidirectional, i.e., migraine headaches may increase the risk of anxiety/depression and vice versa [42,43]. Therefore, there is a need to identify these migraine patients who require special psychiatric care. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/278701615927315-1443459051842_Q64/Tarannum-Lateef.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1055027179307008-1628549489338_Q64/Kathleen-Merikangas-2.jpg)
... 26,27 Additionally, lower HRV, particularly in the HF range, has been associated with increased food cravings. 28,29 This interconnection between cravings, emotional regulation, and HRV in addiction suggests that interventions targeting HRV enhancement and emotional regulation may aid in addiction management. Higher HRV is associated with better emotional control, potentially reducing cravings. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/286331772129282-1445278223207_Q64/Jia-Wu-18.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/272359705804817-1441947022525_Q64/Michael-Crowley-10.jpg)
... These conditions can be challenging to diagnose, especially in children aged 3-17 years, owing to the similarities in their presentation to autism, which leads to diagnostic complexities. An overactive immune response to infection can trigger autoimmune encephalitis and cause brain inflammation and neuropsychiatric symptoms that may resemble or exacerbate autism symptoms [60][61][62]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/11431281189076913-1694892072801_Q64/Jennifer-Chain-4.jpg)
... This is particularly true for pharmacotherapy as individuals with ASDs were more susceptible to the side effects of these pharmacotherapeutic modalities compared to individuals without ASDs [23,24]. Additionally, individuals with ASDs were shown to exhibit paradoxical reactions to some drugs [25]. Medical students are the future workforce of physicians in all specialties. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/277576611319811-1443190829533_Q64/Cristan-Farmer.jpg)
... The youth TSST protocol thus maintains important elements of a stress-inducing task, including a threat to the social self, uncontrollability, and unpredictability. This protocol has been shown to raise blood pressure, heart rate, and salivary cortisol in children and adolescents, even when controlling for the novelty of visiting a laboratory [42], and has been shown to reliably induce stress in adolescent populations in clinical settings [43]. Following the TSST, participants rated how anxious they felt during the task from 1 ("Not at all") to 6 ("Extremely") using a visual analog scale (VAS). ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/640337542410246-1529679775783_Q64/Victoria-Doretto.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/280332868833287-1443847972962_Q64/Stefon-Van-Noordt.jpg)
... This finding could suggest that other factors beyond inflammation may contribute to make subjects affected by AD vulnerable to affective disorders such as cortisol release dysregulation, altered lipid metabolism, and a sedentary lifestyle associated with overweight [40]. Of note, with regard to the identified predictors of persistence of depression in our sample, several studies indicate that a higher BMI is associated with more severe mood disorders [41,42] as a result of common pathophysiological processes underlying obesity and depressive illness (e.g., leptin/insulin dysregulation or intestinal microbiome alterations) [43]. A similar association was reported for BMI and AD, formulating the hypothesis that hypertrophied adipocytes contribute to a pro-inflammatory state [44]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/594769801666560-1518815579553_Q64/Jennifer-Glaus.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/272594855264262-1442003086248_Q64/Kathleen-Merikangas.jpg)
... The following assumptions deserve to be considered. In recent findings, immune dysregulation has been shown to be one of the primary risk factors in the pathogenesis of psychiatric disorders (35)(36)(37)(38)(39). Genetic studies have shown that genes involved in immune modulation (major histocompatibility complex loci) are significantly correlated with SCZ (40). ...
... While the rates of symptom remission are unknown, many children have persistent difficulties that last through childhood and into their adolescence. [17][18][19][20] What Should the Evaluation of Obsessions, Compulsions, and Tics Include? ...
... At the 1-month followup, children who had received either IVIG or TPE showed a significant improvement in OCD symptoms, anxiety, depression, emotional lability, and global functioning compared to baseline. 37 In another randomized controlled trial of IVIG versus placebo, 38 the IVIG group did not demonstrate a statistically significant improvement in OCD severity compared to the control group. During the following open-label phase of the trial, those treated with IVIG showed a significant improvement in OCD severity compared to baseline. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/921962742312960-1596824455618_Q64/Heidi-Grantz.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/273655380836370-1442255935365_Q64/James-Leckman.jpg)
... The copyright holder for this preprint this version posted April 30, 2024. ; https://doi.org/10.1101/2024.04.26.24306193 doi: medRxiv preprint ADHD, attention-deficit hyperactivity disorder; OCD, obsessive compulsive disorder; ASD, autism spectrum disorder; SC, Sydenham chorea; PANS, pediatric acute-onset neuropsychiatric syndrome; HiAD, high-IQ autistic disorder; LoAD, low-IQ autistic disorder; AS, Asperger syndrome; HFA, high-functioning autism While there are >70 neurological soft signs and >160 exam maneuvers, 66 the exam maneuvers used in this study were chosen because PANS is a suspected basal ganglia inflammatory disorder [3][4][5][6][7][8][9] and these maneuvers are sensitive to basal ganglia dysfunction. However, the pathophysiology is likely more complex and other circuits may be involved. ...
