Razieh Zare's research while affiliated with Shiraz University of Medical Sciences and other places

... Smoking was responsible for more than 1.19 million lung cancer deaths, or 63.17% of all fatalities. [1][2][3] Due to population ageing and expansion, lung cancer fatalities have continuously climbed over the past 28 years. 4,5 Strengthening tobacco prevention is necessary, particularly in nations where smoking is prevalent. ...

... P21-activated kinase-1 (PAK1) is an important effector protein of CDC42 and is closely related to cell motility [41]. Several studies have indicated that paxillin is involved in the regulation of endothelial cell proliferation, migration, and angiogenesis [42,43]. In the present study, PAK1 expression was significantly elevated in cells with simultaneous overexpression of CDC42 and inhibition of MALAT1 compared to cells with only MALAT1 inhibition. ...

... Another study showed that olmesartan significantly increased intercellular ROS, which can be considered as a possible mechanism in olmesartan-induced toxicity in MCF-7 and HeLa cell lines, thus corroborating the documented information that an excessive amount of ROS can cause oxidative damage to proteins, DNA, and lipids and can lead to mitochondrial dysfunction, provoking oncogenic transformation, as well as increased metabolic activity, necrosis, and apoptosis [82][83][84]. The combination of telmisartan and docetaxel was shown to inhibit growth in tumor cells (PC-3, DU145, MDA-MB-468, and HEK cell lines) and reduce the expression levels of Snail and Slug genes [85]. ...

... The study also found that the addition of carbon and nitrogen increased the yield strength, tensile strength, and elongation of the as-cast alloys. Furthermore, researchers have investigated the effect of different production methods, such as hot rolling, centrifugal casting, vacuum-pressure casting, and SLM on the mechanical properties and surface roughness of cobalt-chromium alloys [20][21][22][23]. ...

... Embryos transferred in ER-α knockout mice were shown not to be implanted, suggesting that ER-α is required for implantation [26]. A study in diabetic rats suggested that FA supplement reduced ESR1 expression in the uterus [27]. However, another study determined that folate deficiency in mice decreased ESR1 on the fifth day of pregnancy [5]. ...

... Although the biological mechanisms of smoking in PCOS development are not yet fully elucidated, several studies offer plausible explanations. Nicotine, a primary component of tobacco smoke, can participate in oxidative stress by generating reactive oxygen species and may act as a pro-oxidant in endometrial cells (38). Nicotine exposure can also lead to abnormalities in normal insulin signaling pathways, potentially exacerbating insulin resistance (39). ...

... Oxidative stress is a pathological state in which the balance between the production and elimination of reactive oxygen species is disrupted. Reactive oxygen species, mainly hydroxyl radicals, superoxide anions, and hydrogen peroxide are generated during physiological mitochondrial metabolism and cellular responses to exogenous components such as antitumoral pharmaceutics, which could be followed by damage to vital cellular macromolecules and induction of inflammation [5]. ...

... The administration of QCT (20 mg/Kg) and Vit.E (200 mg/Kg) was performed daily by gavages. Doxorubicin administration started on the third day of the experiment (applied by 7 intraperitoneal injections in cumulative doses 15 mg/Kg) [11][12][13]. The treatment of animals was performed by a person experienced in animal care and handling who was blinded to studied materials and grouping. ...