Quan Chen's research while affiliated with First Affiliated Hospital of China Medical University and other places
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Publications (6)
The pathogenesis of Alzheimer's disease (AD), a degenerative disease of the central nervous system, remains unclear. The main manifestations of AD include cognitive and behavioral disorders, neuropsychiatric symptoms, neuroinflammation, amyloid plaques, and neurofibrillary tangles. However, current drugs for AD once the dementia stage has been reac...
Background
The pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE—an animal model of MS) is primarily mediated by T cells. However, recent studies have only focused on interleukin (IL)‐17‐secreting CD4⁺ T‐helper cells, also known as Th17 cells. This study aimed to compare Th17 cells and IL‐17‐secreting CD8⁺ T...
Background
Myasthenia gravis (MG) and the experimental autoimmune MG (EAMG) animal model are characterized by T-cell-induced and B-cell-dominated autoimmune diseases that affect the neuromuscular junction. Several subtypes of CD4⁺ T cells, including T helper (Th) 17 cells, follicular Th cells, and regulatory T cells (Tregs), contribute to the patho...
Stiff person syndrome (SPS) is a rare central nervous system disorder associated with malignancies. In this review, we retrieved information from PubMed, up until August 2023, using various search terms and their combinations, including SPS, stiff person syndrome spectrum disorders (SPSSDs), paraneoplastic, cancer, and malignant tumor. Data from pe...
Background
The pathogenesis of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), is primarily mediated by T cells. However, recent studies have only focused on CD4 + T-helper cells that secrete interleukin-17 (IL-17), also known as Th17 cells. This study aims to determine the similarities and differences...
Alzheimer’s disease (AD) is the most common chronic neurodegenerative disease worldwide. It causes cognitive dysfunction, such as aphasia and agnosia, and mental symptoms, such as behavioral abnormalities; all of which place a significant psychological and economic burden on the patients’ families. No specific drugs are currently available for the...
Citations
... Based on the results of this pathology, as well as other diseases involving memory disorders, degeneration of cholinergic neurons occurs very often, the level of Ach-a key neurotransmitter for memory Pharmaceuticals 2024, 17, 809 2 of 18 regulation-decreases, and impairment of cholinergic transmission follows. In connection with these, the most important symptom of AD is memory loss and cognition-related disturbances [1,2]. Currently, the treatment of cognitive disorders is based only on symptomatic management. ...
