Qiu-Shi Wang's research while affiliated with Third Military Medical University and other places
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Publications (4)
Traumatic brain injury (TBI) survivors suffer from long-term disability and neuropsychiatric sequelae due to irreparable brain tissue destruction. However, there are still few efficient therapies to promote neurorestoration in damaged brain tissue. This study aimed to investigate whether the pro-oncogenic gene ski can promote neurorestoration after...
Background: TGF-β1 promotes cell proliferation in only some tumors and exerts bidirectional regulatory effects on the proliferation of fibroblasts. This study intends to explore whether the mechanism is related to increased expression of Ski.
Methods: Cell proliferation of the fibrosarcoma cell line L929 was assessed with an ELISA BrdU kit. The mRN...
Lung cancer is the most common cause of cancer-associated mortality in China with 85% of patients having non-small cell lung cancer (NSCLC). Identifying NSCLC driver genes and prognostic markers is critical to reducing these numbers. The studies of retinoblastoma binding protein 6 (RBBP6) performed on NSCLC is limited. The present study aimed to in...
Gastrointestinal stromal tumors (GISTs) are the most commonly diagnosed primary mesenchymal tumors of the gastrointestinal tract and 30% of GISTs are associated with a high recurrence risk or metastasis. The current risk classification criteria of the National Comprehensive Cancer Network are based on tumor size, mitotic activity and localization....
Citations
... Reduced neurological deficits and brain water content; Multiple HBO sessions/ day were more protective than a single session Gene therapy FPI 112 Rat (#) 20 min post-TBI; VEGF-ZFP Functional recovery; reduced apoptosis; increased microvascular density and diameter CCI 114 Juvenile rat (# & $) 7 days post-TBI; human GR Improved spatial learning and memory CCI 115 Mouse (#) Soon after TBI; ski Reduced lesion volume and astrogliosis; Improved neurological recovery; promoted neurogenesis Weight-drop 113 Rat (#) 15 min post-TBI; IGF-1 Reduced oxidative stress & cognitive deficits Dietary adaptation CCI 57 Rat (#) Pre-and post-TBI 30% CR Improved spatial learning and memory Reduced lesion volume; upregulation of BDNF expression CCI 65 Juvenile rat (#) Post-TBI KD for 7 days Reduced cortical contusion volume at PND35 and PND45, but not PND17 and PND65 ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/272327392886795-1441939318276_Q64/Ren-Ping-2.jpg)
... Canonical TGF-β signaling is correlated with the activation of serine/ threonine kinase receptors, thereby facilitating the phosphorylation of receptor-regulated SMADs (R-Smads; SMAD2 and SMAD3). R-Smads and SMAD4 can generate heteromeric complexes, which exhibit nuclear translocation and accumulation [12,13]. Moreover, R-Smads can modulate the levels of target genes along with cofactors or sequence-specific transcription factors [14]. ...
... Motadi et al. [38] have demonstrated that RBBP6 mRNA and its protein products are expressed in human lung cancer. However, little is known regarding its clinical and pathological significance in various cancers, including CC. Due to its ability to interact with p53 and facilitate its degradation, RBBP6 is a promising candidate for targeted drug therapy in cancer treatment [39,40]. Moreover, since RBBP6 is implicated in the degradation of p53 within cells, there is a necessity to gain a detailed understanding of how it interacts with p53 at the molecular level. ...
