Qingqing Cai's research while affiliated with Xi'an Jiaotong University and other places
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Publications (22)
Intelligence Quotient (IQ) is a vital index to evaluate the ability of an individual to think rationally, learn from experience, and deal with the environment effectively. However, limited efforts have been paid to explore the potential associations of IQ traits with the tissue proteins from brain, cerebrospinal fluid (CSF) and plasma.
The informat...
Although previous studies have explored the associations of white matter hyperintensity with psychiatric disorders, the sample size is small and the conclusions are inconsistent. The present study aimed to further systematically explore the association in a larger sample. All data were extracted from the UK Biobank. First, general linear regression...
Background
Bone mineral density (BMD) is a major predictor of osteoporotic fractures, and previous studies have reported the effects of mitochondrial dysfunction and lifestyle on BMD, respectively. However, their interaction effects on BMD are still unclear.
Objective
We aimed to investigate the possible interaction of mitochondrial DNA (mtDNA) an...
The objectives of this study were to investigate the interaction of mitochondrial DNA (mtDNA) and lifestyle factors in the development of psychiatric disorders and to gain greater insight into their pathogenesis and comorbidity. We analyzed data from approximately 150,000 individuals from the UK Biobank. Mitochondrial gene-by-environment interactio...
Background
Depression has been linked to an increased risk of cardiovascular and respiratory diseases; however, its impact on cardiac and lung function remains unclear, especially when accounting for potential gene–environment interactions.
Methods
We developed a novel polygenic and gene–environment interaction risk score (PGIRS) integrating the m...
The establishment of 3ʹaQTLs comprehensive database provides an opportunity to help explore the functional interpretation from the genome-wide association study (GWAS) data of psychiatric disorders. In this study, we aim to search novel susceptibility genes, pathways, and related chemicals of five psychiatric disorders via GWAS and 3ʹaQTLs datasets...
Aims
Addiction is currently seen as a neuropsychiatric disorder with genetic component involved. Multiple chronic bowel disorders could exert influence on mental status including addition. This study aims to investigate the genetic correlation of addiction-related traits and chronic bowel disorders.
Methods
We extracted addiction-related traits in...
Bone mineral density (BMD) is an essential predictor of osteoporosis and fracture. We conducted a genome-wide trajectory analysis of BMD and analyzed the BMD change.PurposeThis study aimed to identify the genetic architecture and potential biomarkers of BMD.Methods
Our analysis included 141,261 white participants from the UK Biobank with heel BMD p...
Background:
Smoking and alcohol consumption were associated with the development of depression and anxiety. 3'UTR APA quantitative trait loci (3'aQTLs) have been associated with multiple health states and conditions. Our aim is to evaluate the interactive effects of 3'aQTLs-alcohol consumption/tobacco smoking on the risk of anxiety and depression....
Objectives:
Previous studies identified a number of diseases were associated with 2019 coronavirus disease (COVID-19). However, the associations between these diseases related viral infections and COVID-19 remains unknown now.
Methods:
In this study, we utilized single nucleotide polymorphisms (SNPs) related to COVID-19 from genome-wide associat...
Objective
Genetic approaches are increasingly advantageous in characterizing treatment-resistant schizophrenia (TRS). We aimed to identify TRS-associated functional brain proteins, providing a potential pathway for improving psychiatric classification and developing better-tailored therapeutic targets.
Methods
TRS-related proteome-wide association...
Infection-induced perturbation of immune homeostasis could promote psychopathology. Psychiatric sequelae have been observed after previous coronavirus outbreaks. However, limited studies were conducted to explore the potential interaction effects of inflammation and coronavirus disease 2019 (COVID-19) on the risks of anxiety and depression. In this...
There is a strong link between irritable bowel syndrome and brain volumes, yet little research to date has examined the mediators of this association. Based on the phenotypic data of 15,248 participants from the UK Biobank, a two-stage mediation analysis was performed to assess the association among brain volumes, anxiety and irritable bowel syndro...
Aim
Few previous studies have investigated the impact of multiple types of electronic devices on health status, and the moderating effects of gender, age, and BMI. Our aim is to examine the relationships between the use of four types of electronics and three health status indicators in a middle-aged and elderly population, and how these relationshi...
Longitudinal changes in brain structure and lifestyle can affect sleep phenotypes. However, the influence of the interaction between longitudinal changes in brain structure and lifestyle on sleep phenotypes remains unclear. Genome-wide association study dataset of longitudinal changes in brain structure was obtained from published study. Phenotypic...
Background:
A bidirectional relationship between chronic pain (CP) and mental disorders has been reported, and coffee was believed to be associated with both. However, the association of coffee in this bidirectional relationship remains unclear. We aim to analyze the association of coffee consumption on the relationship of CP with depression and a...
Background
Gut microbiome and inflammatory bowel disease (IBD) are implicated in the development of depression, but the effect of their interactions on the risk of depression remains unclear. We aim to analyze the effect of interactions between gut microbiome and IBD on the risk of depression, and explore candidate genes involving the interactions....
Background
Previous studies have suggested a potential association between sleep and telomere length (TL), but its genetic basis remains unclear. In this study, we aimed to explore the genetic correlation and potential causal association between TL and insomnia.
Methods
The genome-wide association study (GWAS) datasets of TL and insomnia-related t...
Background: Irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD) were reported to be associated with mental disorders. But limited efforts were made to investigate the relationship between IBS/IBD and the risk of insomnia, especially from genetic perspective.
Methods: Based on the UK Biobank cohort, we first calculated the polygenic...
Objective:
Bitter or sweet beverage perception is associated with alterations in brain structure and function. Our aim is to analyze the genetic association between bitter or sweet beverage perception and human brain proteins.
Materials and methods:
In our study, 8356 and 11,518 proteins were first collected from two reference datasets of human...
Citations
... In contrast, the lack of BMD heritability enrichment in osteoclast annotations and those of their predecessors, monocytes, seems counterintuitive given osteoclasts' critical role in remodeling bone and since disrupted osteoclast activity has been proposed to mediate several specific BMD GWAS loci 58,[77][78][79] . However, as we calculated heritability enrichments on top of the baseline S-LDSC model which accounts for conservation and genomic regulation broadly relevant across cell types, a lack of enrichment in osteoclast annotations does not prohibit isolated BMD GWAS loci from mediating their effects in osteoclasts, it merely suggests that in general, osteoclasts are not as critical to the etiology of BMD as the other enriched cell types. ...
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... Contrary to the similarity in the direction of expression for Olfr1286 in both regions, Tmem245 was downregulated in male NAcore compared to the upregulation in the male PFC. Tmem245 has been linked with schizophrenic psychosis (51), which is similar to psychostimulant-induced psychosis (52). Here, we hypothesize a region-dependent role for Tmem245 in facilitating psychosis-like behavior during cocaine withdrawal linked with increasing the likelihood of seeking cocaine during periods of abstaining cocaine intake. ...
... While the results of these studies provided insights into possible cause-effect relationships, observational studies highlighted a complex interplay between COVID-19 and anxiety where J o u r n a l P r e -p r o o f Journal Pre-proof bidirectional effects and shared pathogenesis could both play a role Zhang et al., 2023). Because of the particular impact that COVID-19 had on anxiety with 35% of the general population reported having anxiety during the pandemic worldwide (Delpino et al., 2022), a more comprehensive analysis of COVID-19 comorbidity with anxiety disorders and traits can shed light on genetic mechanisms that may be important in developing targeted interventions. ...
... [21,26,27] Studies have also revealed the indirect mediating role of anxiety in the association between IBS and brain volumes, shedding light on the functional mechanisms of IBS and its related psychosocial factors. [28] Research aimed to determine the relationship between psychological characteristics and different subtypes and the severity of IBS, highlighted the importance of understanding the psychological aspects of the condition. [29] In the current study, there was a significant association between anxiety and IBS in bivariate and multivariate analysis. ...
... Using the terms "chronic pain, " "depression, " and "UK Biobank" in PubMed (from the inception to March 1, 2024), we found 13 studies including chronic pain and depression through the analysis of UK Biobank [19,20,[35][36][37][38][39][40][41][42][43][44][45]. Of the 13 studies, five focused on genetic information [35,36,39,41,45], five were association analyses [19,37,38,42,44], one examined the role of coffee in the association between chronic pain and depression [43], one was a clinical prediction model for the development and spread of chronic pain [20], and one assessed risk factors for facial pain [40]. ...
... Подчеркивается общность и взаимодействие генетических механизмов депрессии, воспалительных и сердечно-сосудистых заболеваний при формировании риска суицида и суицидального поведения [32]. Значительное количество интересных результатов получено для состояния микробиоты и воспалительных заболеваний кишечника [33][34][35], других заболеваний желудочно-кишечного тракта (ЖКТ), например гастроэзофагеального рефлюкса [36], имеются данные для эректильной дисфункции [37] и почечнокаменной болезни [38]. Важная роль принадлежит исследованиям различных вариантов болевого синдрома [39,40], в том числе хронической боли [41]. ...
... The authors concluded that caffeine consumption should be reduced during pregnancy and that it would be advisable to start an awareness program to avoid these negative consequences on the child's development. The association between taste sensitivity and alterations in brain structures and functions was also studied by Wei et al. [34]. These authors analyzed the genetic association between the perception of sweet or bitter beverages and human brain proteins, since the perception of a bitter or sweet drink is associated with alterations in brain structure and function [35,36]. ...
