Qingang Hu's research while affiliated with Center For Oral & Maxillofacial Surgery and other places
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Publications (134)
Background
Apoptosis can fuel oncogenesis by the education of surrounding stromal cells. However, the function of cancer‐associated fibroblasts (CAFs), which interacted with apoptotic cancer cells, in oral squamous cell carcinoma (OSCC) progression is still unknown.
Objectives
This study aimed to explore the prognostic value of apoptosis and the b...
Background
Tumor metastasis is responsible for the high mortality rate of patients with oral squamous cell carcinoma (OSCC). Although many hypotheses have been proposed to elucidate the mechanism of tumor metastasis, the origin of the metastatic tumor cells remains unclear. In this study, we explored the role of cell fusion in the formation of OSCC...
An active host adaptive response is characterized by the existence of programmed cell death protein 1 (PD‐1) ⁺ /IFN‐γ ⁺ cytotoxic T cells and IFN‐γ‐induced PD‐L1 ⁺ tumor cells (TCs), which predicts high response rate to anti‐PD‐1/L1 therapy. Recently, CD161 and its ligand LLT1 (CLEC2D) have been identified as an emerging checkpoint for immunotherap...
Desmoplasia in fibroblasts within metastatic lymph nodes (MLNs) serves as an indicator of extranodal extension (ENE), which is a critical determinant of distant metastasis and mortality in oral squamous cell carcinoma (OSCC). However, systematic studies on fibroblasts in MLNs are lacking. Therefore, this study investigated and characterized the dif...
Head and neck cancer ranks as the sixth most prevalent malignancy, constituting 5 % of all cancer cases. Its inconspicuous onset often leads to advanced stage diagnoses, prompting the need for early detection to enhance patient prognosis. Currently, research into early diagnostic markers relies predominantly on genomics, proteomics, transcriptomics...
Purpose
Depth of invasion (DOI) in oral squamous cell carcinoma (OSCC) guides treatment and prognosis but lacks three-dimensional (3D) insight. We used Lugol’s iodine-enhanced micro-computed tomography (CT) for 3D analysis.
Methods
Fifteen in vitro OSCC samples from Nanjing Stomatological Hospital (July to December 2022) were micro-CT imaged with...
Objective:
Disease metabolomes have been studied for identifying diagnostic and predictive biomarkers of pathology. Oral tongue squamous cell carcinoma (OTSCC) is one of the most prevalent subtypes of head and neck squamous cell carcinoma, yet the profile and diagnostic value of its tissue metabolite are unclear.
Subjects and methods:
Tumor tiss...
Introduction:
Currently, hyperuricemia has shown a surprisingly rising trend, which attracts widespread attention due to potentially major health risks. Considering the inevitable side effects of long-term medicine, probiotics are emerging as potential therapeutics due to their ability to improve uric acid metabolism and superior safety.
Methods:...
Aims:
Different regions of oral squamous cell carcinoma (OSCC) have particular histopathological characteristics, and the individual histological characteristics of the tumors are poorly understood. Therefore, calculating the proportion of tumor cells in different regions that allow assessment of the prognostic outcomes for OSCC patients would be...
Background:
With the frequent use of Bisphosphonates (BPs), the morbidity of BP-related osteonecrosis of the jaw (BRONJ) is also increasing. However, the prevention and treatment of BRONJ is faced with enormous challenges. This study aimed to illuminate the influence of BP administration in the rat mandible and explore the feasibility of discrimin...
Background:
Loss-of-function of PD-L1 induces therapy resistance of anti-PD-1/L1 therapy, and the complex regulatory mechanisms are not completely understood. We previously reported that stroma-derived interleukin-33 (IL-33) promoted the progression of oral squamous cell carcinoma (OSCC). We here focused on the immune-regulation role of IL-33 and...
IntroductionMetabolite stability is critical for tissue metabolomics. However, changes in metabolites in tissues over time from the operating room to the laboratory remain underexplored.Objectives
In this study, we evaluated the effect of postoperative freezing delay time on the stability of metabolites in normal and oral squamous cell carcinoma (O...
Recurrent aphthous ulcer (RAU), one of the most common diseases in humans, has an unknown etiology and is difficult to treat. Thalidomide is an important immunomodulatory and antitumor drug and its effects on the gut microbiota still remain unclear. We conducted a metagenomic sequencing study of fecal samples from a cohort of individuals with RAU,...
Background:
Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme that catalyzes the methylation of nicotinamide (NAM) to generate 1-methyl nicotinamide (MNAM). Although previous studies have shown that NNMT is frequently dysregulated to promote the onset and progression of many malignancies, its expression profile, prognostic value and fu...
The Pattern Of Invasion (POI) of tumor cells into adjacent normal tissues clinically predicts postoperative tumor metastasis/recurrence of early oral squamous cell carcinoma (OSCC), but the mechanisms underlying the development of these subtypes remain unclear. Focusing on the highest score of POIs (Worst POI, WPOI) present within each tumor, we ob...
[This corrects the article DOI: 10.3389/fcimb.2021.820535.].
The 5-year survival rate for oral squamous cell carcinoma (OSCC), one of the most common head and neck cancers, has not improved in the last 20 years. Poor prognosis of OSCC is the result of failure in early and precise diagnosis. Metabolic reprogramming, including the alteration of the uptake and utilisation of glucose, amino acids and lipids, is...
Background
Periodontitis is considered a risk factor for atherosclerosis, but the mechanism is not clear. It was reported that oral administration of Porphyromonas gingivalis altered the gut microbiota in mice. Gut dysbiosis and the intestinal metabolite trimethylamine N-oxide (TMAO) were verified to be associated with atherosclerosis. Therefore, t...
As a key histopathological characteristic of tumor invasion, perineural invasion (PNI) assists tumor dissemination, whereas the current definition of PNI by dichotomy is not accurate and the prognostic value of PNI has not reached consensus. To define PNI status in each patient when mixed types of PNI occurred simultaneously, we here further subcla...
Cigarette smoking could have certain effects on gut microbiota. Some pioneering studies have investigated effects of active smoking on the microbiome in local segments of the digestive tract, while active smoking-induced microbiome alterations in the whole digestive tract have not been fully investigated. Here, we developed a rat model of active sm...
The survival rate of oral squamous cell carcinoma (OSCC) can be greatly improved if intervention could be initiated as early as possible. This poses a technical demand for developing a sensitive screening and specific in vitro diagnosis method for OSCC. Herewith, a large cohort consisting of 241 healthy contrast (HC) and 578 OSCC patients were recr...
Background: Oral squamous cell carcinoma (OSCC) accounts for 90 % of oral cancers. If a necessary intervention before tumorigenesis could be conducted, the current 60% 5-year survival rate would be expected to be majorly improved. This fact motivates the search for developing a highly sensitive and specific in vitro diagnostic method to conduct rap...
Background
Oxidative stress is involved in the pathogenesis of various inflammatory diseases, such as periodontitis. When periodontitis occurs, reactive oxygen species (ROS) are overproduced and cannot be balanced by the antioxidant defense system, resulting in tissue damage. Madecassic acid (MA), an abundant triterpenoid in Centella asiatica (L.)...
Background
Reelin, an extracellular glycoprotein, is expressed on neuronal cells and participates in neuronal migration during brain development. Recently, Reelin also has a vital role in carcinogenesis. However, its role in oral squamous cell carcinoma (OSCC) remains to be explored. The purpose of this study was to explore the roles of Reelin in O...
Background
Although there is consensus that the optimal safe margin is ≥ 5mm, obtaining clear margins (≥5 mm) intraoperatively seems to be the major challenge. We applied a molecular diagnostic method at the lipidomic level to determine the safe surgical resection margin of OSCC by desorption electrospray ionisation mass spectrometry imaging (DESI-...
Depth of invasion (DOI) and pattern of invasion (POI) indicate tumor invasiveness of oral squamous cell carcinoma (OSCC). However, preoperative DOI evaluation is challenging, and the correlations between DOI and POI are unknown. We aimed to assess DOI and worst pattern of invasion (WPOI) in early-stage OSCC, and evaluate the preoperative predictive...
The purpose of this study was to design silver nanoparticles (AgNPs) poloxamer thermoreversible gel (AgNPs-PL) and investigate whether this gel could provide sustained antibacterial activity against Enterococcus faecalis (E. faecalis) in the root canal. The gels fabricated were characterized in terms of gelatin temperature, particle size, in-vitro...
Background
CD38 belongs to the ribosyl cyclase family and is expressed on various hematological cells and involved in immunosuppression and tumor promotion. Although targeting CD38 antibodies has been approved for treatment of multiple myeloma, the function of CD38 in solid tumor, oral squamous cell carcinoma (OSCC) etc., has not been investigated....
Background:
The heterogeneity of cancer-associated fibroblasts (CAFs) in head and neck squamous cell carcinoma (HNSCC) has been widely acknowledged, but has not yet been elucidated. The potential roles and clinical relevance of CAFs subclusters in HNSCC progression remain obscure.
Methods:
In this study, we combined single-cell and bulk tissue t...
To determine whether the deletion of p16 can correct tooth and mandible growth retardation caused by Bmi1 deficiency, we compared the tooth and mandible phenotypes of homozygous p16‐deficient (p16−/−) mice, homozygous Bmi1‐deficient (Bmi1−/−) mice, double homozygous Bmi1 and p16‐deficient (Bmi1−/−p16−/−) mice to those of their wild‐type littermates...
Dysregulated amino acids metabolism reciprocally interplays with evolutionary phenotypic characteristics of cancer cells to enhance metastasis. The high metastasis potential of oral squamous cell carcinoma (OSCC) can manifest with perineural invasion (PNI). We here aimed to determine the role of amino acids metabolism in OSCCs with different PNI st...
Background:
Accurate assessment of regional lymph node (LN) status is essential for the treatment of head and neck squamous cell carcinoma (HNSCC) patients. In this study, we aimed to compare the difference between intravenous injection of indocyanine green (ICG) and peritumoral injection of ICG in the location of metastatic LNs.
Methods:
Twenty...
Background:
Advanced oral squamous cell carcinoma (OSCC) has large lesions and deep infiltration, and the control of safe surgical margins was difficult. If residual tumor remains after incomplete tumor resection, it can lead to local tumor recurrence or even distant metastasis. This study sought to investigate the clinical application of indocyan...
Objectives: Integrins, the coordinator of extracellular and intracellular signaling, are often found to be aberrant in tumors and can reshape the tumor microenvironment. Although previous studies showed that integrin beta 2 (ITGB2) is important for host defense, its expression profile and role in tumors, especially in cancer associated fibroblasts...
Oral cancer is a multifactorial cancer that affects millions of peoples worldwide. The current exploration aimed to evaluate the mechanisms that thymoquinone nanoencapsulated carrier and its effects on 7,12‐Dimethylbenz[a]anthracene (DMBA) stimulated hamster buccal pouch cancer in Syrian hamster model. Nanocarrier was characterized by SEM, TEM, FTI...
Cancer-associated fibroblasts (CAFs) play a critical role in the onset and progression of malignancies, such as oral squamous cell carcinoma (OSCC), making CAFs a promising druggable target. In this study, gold nanoparticles (GNPs) exhibited unprecedented size dependent anti-CAF potential, wherein the smallest GNPs outperformed the larger counterpa...
A multimodal drug delivery system targeting the tumor microenvironment is an inspiring method for treating cancer tissues, including oral squamous cell carcinomas (OSCC). Such approaches require an efficient and safe drug carrier. Bovine milk derived exosomes are ideal because the source is adequate and have advantages of both synthetic and cell-me...
Orthodontic force-induced osteogenic differentiation and bone formation at tension side play a pivotal role in orthodontic tooth movement (OTM). Platelet-derived growth factor-BB (PDGF-BB) is a clinically proven growth factor during bone regeneration process with unclear mechanisms. Fibroblasts in periodontal ligament (PDL) are considered to be mec...
Significance
We show that the combination of conductive polymer spray mass spectrometry (CPSI-MS) and machine learning provides a simple, fast, and affordable method for oral squamous cell carcinoma diagnosis with 86.7% accuracy. By using CPSI-MS, the direct, high-throughput metabolic profiling of saliva can be readily realized in a noninvasive man...
Although cancer-associated fibroblasts (CAFs) are the most crucial stromal cells, characterizing their heterogeneity is far from complete. Based on our previously identified transcriptional profile of CAFs, we here reported a novel subset of CAFs in oral squamous cell carcinoma (OSCC), which positively expressed CD68, the classic marker of macropha...
Background:
Local resident normal fibroblasts (NFs) are the major source of cancer-associated fibroblasts (CAFs), which are distinguishable from NFs by their tumor-supportive properties. However, the mechanism and the effects underlying the transition of NFs to CAFs in oral squamous cell carcinoma (OSCC) remain unclear.
Methods:
Five pairs of ma...
Growing evidences have demonstrated a pivotal role of chronic inflammation in oral squamous cell carcinoma (OSCC) through the modulation of inflammatory cells and cytokine production. IL-37 is newly discovered anti-inflammatory member of IL-1 family and can bind to IL-18 receptor to inhibit IL-18 (pro-inflammatory member of IL-1 family) function. I...
Background:
MLL2 (mixed-lineage leukemia 2) is recognized as an essential role in regulating histone 3 lysine 4 tri-methylation (H3K4me3) in mammalian cells. It is frequently mutated to promote developmental diseases and tumor initiation. However, the expression pattern of MLL2 and its clinical significance for patients with early-stage oral squam...
To ensure site–specific drug delivery/release in tumor cells and cancer-associated fibroblasts (CAFs) and reduce the systemic toxicity of chemotherapy, a novel drug delivery system called human serum albumin-indocyanine green-cisplatin nanoparticles (HSA-ICG-DDP NPs) was developed in our study. We characterized this system in vitro and in vivo and...
Background:
p16 was often found to be overexpressed in HPV-negative oral squamous cell carcinoma (OSCC) patients and its prognostic values between anatomical subsites were still unclear.
Objective:
The aim of this study is to investigate HPV16 prevalence and p16 expression in three main anatomical subsites of OSCC.
Methods:
One hundred and for...
Herein, an acceptor-donor-acceptor structured small molecule (ITIC) based nanoparticles (NPs) were explored for photothermal therapy application. ITIC NPs show red-shift absorption in near-infrared region, high photostability, and high photothermal conversion...
Previous studies showed that lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is an important participant in tumor progression. However, its prognostic value and functional mechanism in oral squamous cell carcinoma (OSCC) are still unclear. In this study, we analyzed LGALS3BP expression in OSCC tissues via Oncomine databases and immu...
Objectives
Ki67 expression was associated with the prognosis of several tumors and played a key role in the choice of medical treatments. However, the diagnostic value of Ki67 in oral squamous cell carcinoma (OSCC) has not been fully-evaluated. In this study, we aimed to elucidate the prognosis value of Ki67 in large number of OSCC patients.
Findi...
Background
Transforming growth factor‐β (TGF‐β) exerts its versatile function (oncogenic or tumor suppressive role) during the carcinogenesis in tumor microenvironment‐dependent manner. Considering the tumor heterogeneity, spatial and temporal distribution of TGF‐β in oral squamous cell carcinoma (OSCC) remained to be elucidated.
Methods
Formalin‐...
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Objectives:
To compare the success rates, tissue preservation, and esthetics of implants placed in fresh and preserved sockets and to evaluate the factors influencing the outcomes.
Methods:
Medline, Embase, CENTRAL, Wanfang, and China National Knowledge Infrastructure (CNKI) databases were searched electronically, and a manual search was conduct...
Background
Tumor-associated macrophages (TAMs) play an important role in drug resistance in many tumors, including head and neck squamous cell carcinoma (HNSCC). However, how TAMs interact with HNSCC cells to induce drug resistance, especially under hypoxic conditions, is unclear. In this study, we investigated the mechanism of TAM-induced gefitini...
Purpose
This study evaluated the surgical treatment of tumors arising from the parapharyngeal space (PPS) in a single-center setting.
Materials and Methods
This retrospective study was conducted with 28 patients who underwent surgery for primary PPS tumors from 2011 to 2018. Patient clinical features, histologic tumor type, surgical approach, comp...
Oral squamous cell carcinoma (OSCC) is a highly lethal cancer in the world, and the prognosis of OSCC is poor with a 60% 5‐year survival rate in recent decades. Here, we introduced a novel secretory and acid glycoprotein with cysteine rich (secreted protein acidic and rich in cysteine, SPARC), which is correlated with the worst pattern of invasion...
Current surgical treatment for oral squamous cell carcinoma (OSCC) must be as precise as possible to fully resect tumors and preserve functional tissues. Thus, it is urgent to develop efficient fluorescent probes to clearly identify tumor delineation, as well as metastatic lymph nodes. Chemo-photothermal therapy combination attracted a growing atte...
Objectives: (1) To determine whether the biocompatibility of coralline hydroxyapatite (CHA) granules could be improved by using an octacalcium phosphate (OCP) coating layer, and/or functionalized with bone morphogenetic protein 2 (BMP-2), and (2) to investigate if BMP-2 incorporated into this coating is able to enhance its osteoinductive efficiency...
As a nuclear and nucleolar protein, proliferation marker protein Ki-67 (Ki-67) serves a vital role in tumorigenesis due to its positive correlation with tumor proliferation. High expression of Ki-67 in the cell cycle from the G1 to M phase makes it a potential biomarker for certain tumors and useful for selecting medical treatment. However, the dia...
Our study proved that intracellular NOD2 in DCs could be activated by MDP, which could promote maturation and the ability to prime Th0 cells to Th2 cells of DCs exposed to P. gingivalis-LPS. Background: To study the roles of muramyl dipeptide (MDP) in dendritic cells (DCs) exposed to Porphyromonas gingivalis lipopolysaccharide (P. gingivalis-LPS) o...
Background: Ki67 has been a key role for the treatment options and prognosis evaluation in some kinds of tumors; however, the spatial expression of Ki67 in oral squamous cell carcinoma (OSCC) has not been fully-evaluated. Therefore, in the present study, we aimed to elucidate the prognosis value of Ki67 spatial expression including in different cel...
Background
Monocytes, which subdivided into three functional subsets (classical, intermediate, and nonclassical), play important roles in the progression of cancer. The subset composition is altered in several pathologic conditions including cancers. However, the composition and function of circulating monocyte subsets in patients with oral squamou...
The status of lymph node (LN) metastasis, including the number and location of positive LNs, is a significant prognostic factor for oral squamous cell carcinoma (OSCC). Therefore, knowing the number and location of positive LNs is essential for prognosis. However, surgeons often have difficulty locating LNs. In the present study a practical device...
The complex area for reconstruction of the head and the neck is the buccal because of difficult anatomy of this region. This article aimed to describe our individualized design for the reconstruction of the buccal using an different categories anterolateral thigh (ALT) flap. Ninety-four patients were involved in this study. Among 94cases, the numbe...
Stromal carcinoma-related fibroblasts (CAFs) are the main type of non-immune cells in the tumor microenvironment (TME). CAFs interact with cancer cells to promote tumor proliferation. Long non-coding RNAs (lncRNAs) are known to regulate cell growth, apoptosis, and metastasis of cancer cells, but their role in stromal cells is unclear. Using RNA seq...
Magnetic nanoparticles (NPs) of superparamagnetic iron oxide (SPIO) have been explored for different kinds of applications in biomedicine, mechanics, and information. Here, we explored the synthetic SPIO NPs as an adjuvant on antigen cross-presentation ability by enhancing the intracellular delivery of antigens into antigen presenting cells (APCs)....
Objectives:
Margin status and invasion pattern are prognostic factors for oral tongue squamous cell carcinoma (OTSCC). Current methods to identify these factors are limited to 2D observation, it is necessary to explore 3D reconstruction with whole-mount sample to improve analysis accuracy. This study aimed to study the tissue-preparation, section...
In this study, we investigated the cytotoxicity of silver nanoparticles (AgNPs), which showed effective antimicrobial performance on Porphyromonas endodontalis (P.e) in the previous research, on human periodontal ligament fibroblasts (HPLFs) and provided a scientific basis for the therapeutic application of AgNPs on periodontitis. Incubated with va...
Objective:
As compared with the normal anatomy, structures of the skull base and its surroundings have been dramatically altered of the lesion near the skull base. How to remove the lesion at the skull base was mainly depending on surgeon's personal experience during past years. In this study, the authors explored the safety and accuracy of the su...
The weakened tumour colonization of attenuated Salmonella has severely hampered its clinical development. In this study, we investigated whether an anti-inflammation and antiangiogenesis compound triptolide could improve the efficacy of VNP20009, a highly attenuated Salmonella strain, against mice melanoma. By comparing the effects of conventional...
The design paradigm of biomaterials has been changed to ones with favorable immunomodulatory effects, indicating the importance of accurately evaluating the immunomodulatory properties of biomaterials. Among all the immune cells macrophages receive most attention, due to their plasticity and multiple roles in the materials and host interactions, an...
Nanosilver particles (SNPs) have been widely exploited in various fields, including the medical sciences due to their excellent inhibitory and bactericidal effects. It is of great importance to prepare SNPs using green synthesis that has environmentally acceptable solvent systems and eco-friendly reducing agents. In the current study, gallic acid w...
The traditional maximum dose density chemotherapy renders the tumor patients not only the tumor remission but the chemotherapy resistance and more adverse side effects. According to the widely positive expression of Toll-like receptor (TLR)-3 in oral squamous cell carcinoma (OSCC) patients (n=166), we here provided an alternative strategy involved...
As stem cells contribute to the development and homeostasis of normal adult tissues, malfunction of stem cells in self-renewal and differentiation has been associated with tumorigenesis. A growing number of evidences indicating that tumor initiating cells play a crucial role, not only in malignancies, but also in generation and development of benig...
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FADD, a classical apoptotic signaling adaptor, was recently reported to have non-apoptotic functions. Here, we report the discovery that FADD regulates lipid metabolism. PPAR-α is a dietary lipid sensor, whose activation results in hypolipidemic effects. We show that FADD interacts with RIP140, which is a corepressor for PPAR-α, and FADD phosphoryl...
P-15, a synthetic peptide of 15-amino acids, has been tested in clinical trials to enhance cell adhesion and promote osseointe- gration. This feature of P-15 has also inspired the development of designing new bone substitute materials. Despite the increasing applications of P-15 in bone graft alternatives, few studies focus on the mechanism of cell...
Significance:
The present study focused on patient-personalized bone tissue engineering. Human induced pluripotent stem cells (hiPSCs) were established from clinically easily derived human gingival fibroblasts (hGFs) and defined nanohydroxyapatite/chitosan/gelatin (HCG) scaffolds. hiPSCs derived from hGFs had better osteogenesis capability than th...
Objective:
The purpose of this study was to assess the safety and the accuracy of surgical navigation technology in the resection of severe ankylosis of the mandibular condyle with the middle cranial fossa.
Methods:
The computed tomography scan data were transferred to a Windows-based computer workstation, and the patient's individual anatomy wa...
Hydroxyapatite (HA) is an important component of human bone and bone tissue engineering scaffolds. A plethora of bone tissue engineering scaffolds have been synthesized so far, including nano-HA/chitosan/gelatin (nHA/CG) scaffolds; and for seeding cells, stem cells, especially induced pluripotent stem cells (iPSCs), have been a promising cell sourc...
Background:
To compare free thin anterolateral thigh (ALT) flap with free radial forearm (FRF) flap in the reconstruction of hemiglossectomy defects, and to introduce our methods and experience in the tongue reconstruction with free thin ALT flap.
Material and methods:
The clinicopathologic data of 46 tongue carcinoma cases hospitalized from Dec...
Previous studies have indicated that Fas-FasL pathway and its downstream caspase-8 can regulate islet mass and insulin secretion. As a classical adaptor in Fas-FasL signaling, Fas-associated death domain-containing protein (FADD) takes part in many non-apoptosis processes regulated by its phosphorylation. However, its role in islets has not been ev...
Purpose
Vaccines play important roles in antitumor biotherapy. Autophagy in tumor cells plays a critical role in depredating proteins, including tumor-specific antigens and tumor-associated antigens. We aimed to induce and collect tumor-derived autophagosomes (DRibbles) from tumor cells as a novel antitumor vaccine by inhibiting the functions of pr...
Gelsolin (GSN) is one of the most abundant actin-binding proteins, and is involved in several pathological processes, including Alzheimer's disease, cardiac injury and cancer. The aim of the present study was to assess the effect of GSN on the growth and motility of oral squamous cell carcinoma Tca8113 cells. The overexpression vector pcDNA3.1-GSN...
To assess the safety and the accuracy of surgical navigation technology in the resection of severe ankylosis of the mandibular condyle with the middle cranial fossa.
The CT scan data was transferred to a Windows-based computer workstation, and the patient' s individual anatomy was assessed in multiplanar views at the workstation. In the operation,...
To mimic oral squamous cell carcinoma (OSCC) cell hypoxia by using chemical agent CoCl2 and to investigate its biological behaviour.
Oral squamous cell carcinoma cell lines HSC-3 and SCC-4 were exposed to different concentration of CoCl2. HSC-3 and SCC-4 cells were treated with 50, 100, 150, 200 µmol/L CoCl2. Expression of hypoxia inducible factor-...
AimsToll-like receptor 7 (TLR7) agonists has been applied into cancer immunotherapy, but the heterogeneity of tumor renders TLR7 behaves versatile in tumor microenvironment and the characteristic of TLR7 in oral squamous cell carcinoma (OSCC) is unclear.Methods and results20 healthy oral tissues, 50 oral leukoplakia tissues and 166 retrospective pr...
Background:
To investigate the clinicopathological features of six cases of soft tissue recurrent ameloblastoma and explore the role of increased aggressive biological behavior in the recurrences and treatment of this type of ameloblastomas.
Material and methods:
In this study, we retrospectively reviewed recurrent ameloblastomas during a 15-yea...
Background
This study was performed to examine whether lipopolysaccharide can influence cell migration and epithelial–mesenchymal transition of oral squamous cell carcinoma.Methods
Three oral squamous cell carcinoma cell lines (HSC3, CAL27, and SCC4) were obtained for the study. TLR4 expression in three cell lines was analyzed by Q-PCR and Western...
Objective
The aim of this study is to investigate the expression and function of TLR3 in oral squamous cell carcinoma (OSCC).
Design
We first assessed TLR3 expression in 20 cases of primary OSCC tissue. Then two OSCC cell lines SCC4 and CAL27 were used for further study. Poly(I:C) was used to activate TLR3 expressed by OSCC. Then changes of cytoki...
Objective:
To compare the thin anterolateral flap with forearm flap in tongue defect repairing, and to introduce our methods and experiences in the tongue reconstruction with the thin anterolateral flap.
Methods:
The clinicopathologic data of 46 cases with tongue carcinoma were obtained from School of Stomatology, Nanjing University Medical Cent...
Citations
... To date, only one study has been recently published by Hu et al. [19] that examined the expression patterns of CD161/LLT1 in OSCC and the impact on patient prognosis. This prompted us to investigate the clinical relevance of LLT1 expression in the OSCC TIME. ...
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... This highlights the metabolic alterations that cancer cells acquire in order to produce more ATP and metabolic intermediates, which power the synthesis of biological macromolecules and aid in cell survival, development, and multiplication. An acidic microenvironment is created by pyruvate, an end product of glycolysis that preferentially accumulates in cancer cells and is transformed to lactic acid by lactate dehydrogenase, which promotes the growth and invasion of cancer cells [10,11]. In HNSCC, there is an adverse correlation between high lactic acid levels and overall patient survival [12]. ...
... Statistical analyses were performed as previously described (Wang et al., 2023b). A brief description is as follows: To statistically analyze the serum metabolite profiles of OKC patients and HCs, we performed multivariate statistical analyses, including principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA). ...
... Similarly, a study was reported by Liang et al., where the administration of L. gasseri LG08 and L. mesenteroides LM58 orally was found to have a notable impact on the expression of Occludin and Claudin proteins. These proteins are known to have a crucial role in preserving the integrity and functionality of the intestinal mucosal barrier [41]. Furthermore, the study determined that sodium butyrate had a potential therapeutic effect and impaired intestinal mucosa barrier induced the mRNA and protein expression levels of mus-2, Zo-1, Occludin, and ABCG2, which reduced UA production [42]. ...
... While Raman spectroscopy is widely used in various fields, including the detection of tumors in biology and medicine, its application in discriminating BRONJ has been reported only infrequently. Our findings are consistent with some authors 43 and contradicted by others 44 , highlighting the need for additional studies to more comprehensively evaluate BRONJ lesions using Raman spectrometry. ...
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... Currently, there are 3 major approaches to humanize mice: peripheral blood mononuclear cells (Hu-PBMCs), hematopoietic stem cells (Hu-HSCs), and bone marrow-liver-thymus (Hu-BLT) (De La Rochere et al. 2018). Scientists used the Hu-PBMC mouse model to analyze the relationship between IL-33/ST2 signaling and PD-L1 expression in HNSCC patients and cell lines (Zhao et al. 2023). They further confirmed this correlation in these humanized mice, demonstrating the role of ST2/PD-L1-mediated immune tolerance in tumor growth in vivo. ...
... The digital HEstained slides were also reviewed by CaseViewer 2.4 for Windows (3DHISTECH Ltd.), a digital application for evaluating microscopy images. Specific procedures have been previously published (Wang et al., 2022). After digitization of the tissue slides was completed, histological evaluation was performed independently by two experienced pathologists (X.H. and L.Z). ...
... Gut microbiota is increasingly recognized as a key factor in human health (Gilbert et al., 2018). A large number of studies have shown that changes in gut flora are closely linked to the development of type 2 diabetes (Bajzer and Seeley, 2006;Wang et al., 2022;Zhang et al., 2010). Some studies have shown that polysaccharides exert hypoglycemic and hypolipidemic activities mainly by reducing the abundance of harmful bacteria and increasing the abundance of beneficial bacteria (Liu et al., 2017). ...
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... To the best of our knowledge, there have been no direct studies on NNMT expression in OCCA. Growing evidence has shown that NNMT is aberrantly expressed in several cancers and is a promising prognostic predictor in cancers such as gastric carcinoma, oral squamous cell carcinoma, ovarian cancer, hepatocellular carcinoma, and nasopharyngeal carcinoma [13][14][15][16][17]. NNMT expression reduces sensitivity to anticancer drugs in several cancer cell types. ...
... When they escape anti-tumor immune responses, OSCC cells proliferate uncontrollably, thereby infiltrating the tissue in which they have developed and replacing pre-existing normal cells [92,93]. This is by reason that OSCC cells are invasive, that is, they produce proteolytic enzymes capable of degrading the intercellular junctions and both the interstitial and the peritumoral extracellular matrix [94]. ...
