Qin Yang's research while affiliated with McGill University Health Centre and other places
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Publications (11)
Development of the mammalian oocyte requires physical contact with the surrounding granulosa cells of the follicle, which provide it with essential nutrients and regulatory signals. This contact is achieved through specialized filopodia, termed transzonal projections (TZPs), that extend from the granulosa cells to the oocyte surface. Transforming g...
Development of the mammalian oocyte requires physical contact with the surrounding granulosa cells of the follicle, which provide it with essential nutrients and regulatory signals. This contact is achieved through specialized filopodia, termed transzonal projections (TZPs), that extend from the granulosa cells to the oocyte surface. Transforming g...
Development of the oocyte requires physical contact with the surrounding granulosa cells of the follicle, which provide it with essential nutrients and regulatory signals. This contact is achieved through specialized filopodia, termed transzonal projections (TZPs), that extend from the granulosa cells to the oocyte surface. Transforming growth fact...
Development of the oocyte requires physical contact with the surrounding granulosa cells of the follicle, which provide it with essential nutrients and regulatory signals. This contact is achieved through specialized filopodia, termed transzonal projections (TZPs), that extend from the granulosa cells to the oocyte surface. Transforming growth fact...
Development of the mammalian oocyte requires physical contact with the surrounding granulosa cells of the follicle, which provide it with essential nutrients and regulatory signals. This contact is achieved through specialized filopodia, termed transzonal projections (TZPs), that extend from the granulosa cells to the oocyte surface. Transforming g...
Granulosa cells of growing ovarian follicles elaborate filopodia-like structures termed transzonal projections (TZPs) that supply the enclosed oocyte with factors essential for its development. Little is known, however, of the mechanisms underlying the generation of TZPs. We show in mouse and human that filopodia, defined by an actin backbone, emer...
Dear Editor,
Growth and development of the ovarian follicle depends on coordinated signaling between the germ-line and somatic cells. Among the interactions so far identified is that coupling Jagged ligand, expressed in the germ cell, to the Notch receptor, expressed in granulosa cells [1]. Targeted deletion of Jag1 or Notch2 in the oocyte or granu...
Germ cells are physically coupled to somatic support cells of the gonad during differentiation, but this coupling must be disrupted when they are mature, freeing them to participate in fertilization. In mammalian females, coupling occurs via specialized filopodia that project from the ovarian follicular granulosa cells to the oocyte. Here, we show...
Analysis of the mechanisms that drive the growth and meiotic maturation of the female germ cell, the oocyte, has been greatly facilitated by the development of conditions that support these processes in vitro. Easily identified signposts of oocyte differentiation enable the ability of specific culture conditions to recapitulate normal oocyte develo...
Germ cells develop in a microenvironment created by the somatic cells of the gonad [1-3]. Although in males, the germ and somatic support cells lie in direct contact, in females, a thick extracellular coat surrounds the oocyte, physically separating it from the somatic follicle cells [4]. To bypass this barrier to communication, narrow cytoplasmic...
Citations
... The growth regulation of TZP in granulosa cells by oocytes is described above, but the molecular regulation of TZP by granulosa cells is yet to be fully elucidated. Myo10 has been shown to inhibit TZP function, but no cases of developmental defects caused by Myo10 inhibition have been found, so this factor may be nonessential for TZP development [41,54]. In addition, embryonic (A)-binding protein (EPAB) and proline-rich tyrosine kinase (PTK2) can affect the function of E-cadherin, leading to structural instability and a reduction in TZP [55]. ...
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... Research has found that EGFR is activated by the luteinizing hormone (LH) surge during ovulation, leading to phosphorylation of ERK/MAPK kinases and increased calcium calpain activity in granulosa cells. This results in the disruption of the complex between N-cadherin on the surface of cumulus cells and E-cadherin on the surface of oocytes, leading to the detachment of oocytes from granulosa cells and the achievement of ovulation (Abbassi et al. 2021). MDM2 mediates the ubiquitination of p53/TP53 and has been shown to be expressed in growing follicles and corpora lutea during the peri-ovulatory period. ...
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... GOCs were obtained as previously described (El-Hayek et al., 2018b;O'Brien et al., 2003). Briefly, ovaries of 10-to 12-day-old mice were dissected from the ovarian bursa. ...
... Granulosa cells, crucial for follicular development and ovulation, are intimately linked to the anovulation and metabolic abnormalities observed in PCOS [60][61][62]. To better understand the potential role of A-to-I RNA editing in granulosa cells, we also conducted a pairwise comparison and identified consistent DRE in granulosa cells across the five datasets (Table 2). ...
