Qin-Qin Zhang's scientific contributions
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Publications (7)
Fifteen undescribed diterpenoid quinones salviamilthone A-O (1-15), together with three known diterpenoid quinones (16-18), were isolated from the roots of Salvia miltiorrhiza Bunge. Their structures were elucidated using 1D and 2D NMR data, while the relative and absolute configurations were confirmed by NOESY correlations and comparison between e...
Seven new diterpenoids quinones (1-6), together with five known ones (7-11), were isolated from the roots of Salvia miltiorrhiza Bunge. Their structures were elucidated by using 1D and 2D NMR data, while the relative and absolute configurations were confirmed by interpretations of the NOESY correlations and comparison of the experimental and calcul...
Three new phenolic acid derivatives, 1-methyl glyceric acid-2-vanillic acid ether (1), methyl 2-hydroxy-6-(3-methoxy-3-oxoprop-1-en-2-yloxy) benzoate (2), methyl 2-hydroxy-6-(1-Carboxyvinyloxy) benzoate (3) and five known compounds namely 4-hydroxymellein (4), mellein methyl ether (5), 2-methyl-5,7-dihydroxychromone (6), latifolicinin C (7) and ore...
Two new diterpenoid quinones, salvianolactone acid J and K (1 and 2), as well as eight known compounds (3–10) were isolated from the roots of Salvia miltiorrhiza. Their structures were elucidated by comprehensive analysis. All compounds (1-10) were evaluated for their protective effects against the BEAS-2B cells injury induced by LPS in vitro and c...
This study aims to investigate mechanism of "Ephedrae Herba-Descurainiae Semen Lepidii Semen" combination(MT) in the treatment of bronchial asthma based on network pharmacology and in vivo experiment, which is expected to lay a theoretical basis for clinical application of the combination. First, the potential targets of MT in the treatment of bron...
This study aimed to report the structure elucidation of the compounds isolated from Salvia miltiorrhiza, and their biological evaluations. Ten undescribed diterpenoid quinones and 10 known analogues were isolated from the dried roots of S. miltiorrhiza. Their structures were elucidated by extensive analysis, including nuclear magnetic resonance, hi...
Citations
... (Approval No. DWLL2018080003). Rats were allowed to acclimate for one week and were subsequently randomly divided into the following groups: normal group (CON, n ¼ 10); model group (M, n ¼ 10); dexamethasone group (DEX, 0.075 mg/kg [16], n ¼ 10); and B-SIT group (B-SIT, 50 mg/kg, n ¼ 10). The CON group was intraperitoneally injected with normal saline(NS, 1 ml/0.2 ...
... Until now, phytochemical investigations of E. sinica and E. equisetina have revealed a wide variety of phytochemical constituents including alkaloids (Zhu et al., 2022a(Zhu et al., , 2022b(Zhu et al., , 2022c, flavonoids (Purev et al., 1988), organic acids , lignans (Zhu et al., 2022a(Zhu et al., , 2022b(Zhu et al., , 2022cFan et al., 2022), and tannins (P.M. B. M. Zhang et al., 2018), whilst the related research on E. intermedia is limited. During our search for bioactive natural products from E. intermedia, two new lignans (Fig. 1), along with seven known compounds were isolated. ...
... In our efforts to discover more diterpenoid quinones from S. miltiorrhiza (Ren et al., 2022), two new diterpenoid quinones, salvianolactone acid J and K (1 and 2), as well as eight known analogues (3-10) were isolated from this plant, and their lung protective activity were evaluated. ...