Qi Zhou's research while affiliated with First Affiliated Hospital of China Medical University and other places
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Publications (123)
5619
Background: Antiangiogenic therapy plus immunotherapy significantly improved PFS and OS as compared to chemotherapy among pts with previously treated advanced EMC per KEYNOTE-775 study. However, no combination immunotherapies are currently approved for EMC in China. Fruquintinib (F, a highly selective VEGFR inhibitor) plus sintilimab (S, an an...
5509
Background: Preliminary clinical data of oral TORC1/2 inhibitor, onatasertib (ATG-008), demonstrated anti-tumor activity and acceptable tolerability when combined with toripalimab (tori), an anti-PD-1 monoclonal antibody in solid tumors, especially in cervical cancer (CC). Here, we present results from the anti-PD1 naïve CC cohort of the TORCH...
Background
The prospective phase III multi-centre L-MOCA trial (NCT03534453) has demonstrated the encouraging efficacy and manageable safety profile of olaparib maintenance therapy in the Asian (mainly Chinese) patients with platinum-sensitive relapsed ovarian cancer (PSROC). In this study, we report the preplanned exploratory biomarker analysis of...
Background
Niraparib significantly prolonged progression-free survival versus placebo in patients with platinum-sensitive, recurrent ovarian cancer (PSROC), regardless of germline BRCA mutation (gBRCAm) status, in NORA. This analysis reports final data on overall survival (OS).
Methods
This randomised, double-blind, placebo-controlled, phase 3 tri...
Introduction/Background
In the randomised, double-blind, placebo-controlled phase 3 NORA trial (NCT03705156) among patients with platinum-sensitive recurrent ovarian cancer (PSROC), niraparib maintenance therapy using an individualised starting dose (ISD) demonstrated a significant improvement in progression-free survival at the primary analysis an...
Objective
Cervical cancer constitutes a formidable health challenge imperiling the well-being and lives of women globally, particularly in underdeveloped nations. The survival rates among patients diagnosed with cervical cancer manifest considerable heterogeneity, shaped by a myriad of variables. Within the scope of this inquiry, a predictive model...
Objectives
The aims of this retrospective study were to evaluate the clinical applicability of the latest International Society for the Study of Vulvovaginal Disease (ISSVD) and International Federation for Cervical Pathology and Colposcopy (IFCPC) terminology for vulvar diseases, and to explore a new evaluation flow to optimize decision-making on...
This study aims to characterize the genetic variability of HPV58, identify novel lineages and sublineages, and explore the association between persistent/multiple HPV58 infections and genetic variation. In this study, samples from 124 women with HPV58 infection in Eastern China were collected and 81 isolates of E6 and L1 full‐length genes were succ...
Objective
There is an unmet need to improve clinical outcomes for patients with recurrent/metastatic cervical cancer. Checkpoint inhibitors represent a promising treatment strategy. We evaluated the safety and anti-tumor activity of zimberelimab, an anti-programmed cell death protein-1 antibody, in patients with previously treated, recurrent, metas...
Background
Mucinous epithelial ovarian cancer (mEOC) is a relatively uncommon subtype of ovarian cancer with special prognostic features, but there is insufficient research in this area. This study aimed to develop a nomogram for the cancer-specific survival (CSS) of mEOC based on Surveillance, Epidemiology, and End Results (SEER) database and exte...
Background
To investigate the prognostic relevance of the time to interval debulking surgery (TTS) and the time to postoperative adjuvant chemotherapy (TTC) after the completion of neoadjuvant chemotherapy (NACT).
Methods
A retrospective real-word study included 658 patients with histologically confirmed advanced epithelial ovarian cancer who rece...
Abstract Cervical cancer, the fourth most common cancer among females in the world, ranks the second in China. In advanced disease, metastases may be commonly present in the lungs, bones, liver and lymph nodes or elsewhere, but uncommon to the skin. In this report, a 63‐year‐old woman was diagnosed as stage IVB cervical squamous cell cancer in Janu...
2530
Background: HB002.1T is a recombinant human vascular endothelial growth factor receptor (VEGF)-IgG Fc fusion protein, which functions as a decoy receptor to bind VEGF-A, VEGF-B and placental growth factor (PlGF). In phase Ia, HB002.1T monotherapy showed encouraging anti-tumor activity in gallbladder cancer. Methods: This study aimed to evaluat...
Cancer stem cells (CSCs) play a central role in ovarian cancer (OC), understanding regulatory mechanisms governing their stemness is critical. Here, we report ISYNA1, the rate-limiting enzyme in myo-inositol biosynthesis, as a suppressor of OC regulating cancer stemness. We identified ISYNA1 as a differentially expressed gene in normal ovary and ov...
Human papillomavirus 52 (HPV52) infection is prevalent in the Chinese population, and variations in HPV52 show correlations with oncogenicity. However, no specific variation in HPV52 was reported to show relevancy to infection characteristics. In this study, we retrieved 222 isolates of E6 and L1 full-length genes from 197 Chinese women with HPV52...
Objective
Cervical cancer has one of the highest incidence and mortality rates of any malignant tumor of the female reproductive tract, and its longer treatment period will place significant financial strain on patients and their families. Little is known about how health insurance policies influence cervical cancer prognosis, particularly in devel...
Background:
Cervical cancer is still present a major public health problem, especially in developing countries. In International Federation of Gynaecology and Obstetrics 2018, allowing assessment of retroperitoneal lymph nodes by imaging and/or pathological findings and, if deemed metastatic, the case is designated as stage IIIC (with r and p nota...
Background
Risk stratification of patients with cervical cancer accompanied by positive lymph nodes (stage IIIC) (the 2018 International Federation of Gynecology and Obstetrics [FIGO] new staging system) yields a clinically heterogeneous group. In this study, we investigated the prognostic performance of the 2018 FIGO staging system for stage IIIC...
The aim of this study was to find new protein biomarkers that could be used to detect hepatocellular carcinoma (HCC) in the serum. We identified 11 proteins in the tissue that could be used to classify samples from HCC and control subjects. The 11 identified tissue biomarkers were combined with 10 commonly used serum HCC biomarkers for further veri...
Objective
To produce high‐quality, real‐world evidence for oncologists by collating scattered gynaecologic oncology (GO) medical records in China.
Design
Retrospective study.
Setting
The National Union of Real‐world Gynaecological Oncology Research and Patient Management Platform (NUWA platform).
Sample
Patient‐centred data pool.
Methods
The NU...
Objective
To explore the impact of the primary treatment sequence (primary debulking surgery, PDS, versus neoadjuvant chemotherapy and interval debulking surgery, NACT‐IDS) on post‐relapse survival (PRS) and recurrence characteristics of recurrent epithelial ovarian cancer (REOC).
Design
Real‐world retrospective study.
Setting
Tertiary hospitals...
This phase 2 study assesses the efficacy and safety of camrelizumab (an anti-PD-1 antibody) plus famitinib (anti-angiogenic agent) in women with pretreated recurrent or metastatic cervical cancer (ClinicalTrials.gov NCT03827837). Patients with histologically or cytologically confirmed cervical squamous cell carcinoma experiencing relapse or progres...
Objectives
AL 3818 is a novel, orally administered, small molecule tyrosine kinase inhibitor, that shows highly selective inhibition of fibroblast growth factor receptor (FGFR) and vascular endothelial growth factor receptor (VEGFR). The primary objective of this Phase 3 study is to evaluate the efficacy of AL3818 in combination with chemotherapy i...
Objective:
We aimed to evaluate the effectiveness of different triage strategies for high-risk human papillomavirus (hrHPV)-positive women in primary healthcare settings in China.
Methods:
This study was undertaken in 11 rural and 9 urban sites. Women aged 35-64 years old were enrolled. HrHPV-positive women were randomly allocated to liquid-base...
Objective
To address the value of visual inspection where HPV‐based screening is not yet available, we evaluated the real‐world effectiveness of visual inspection with acetic acid (VIA) and with Lugol's iodine (VILI) as a primary screening method for cervical cancer in rural China.
Methods
A total of 206 133 women aged 30–59 years received two rou...
Although Poly (ADP-ribose) polymerase (PARP) inhibitors' resistance has gradually become a major challenge in the maintenance therapy for high-grade serous ovarian carcinoma (HGSOC), there are no universal indicators for resistance monitoring in patients. A key resistance mechanism to PARP inhibitors (PARPis) is the restoration of homologous recomb...
Purpose:
Recurrent or metastatic cervical cancer patients have limited treatment options after platinum-containing treatment. We initiated a phase 1 study to assess SHR-1701, a novel bifunctional fusion protein composed of a mAb against PD-L1 fused with the extracellular domain of TGF-β receptor II, in solid tumors (NCT03774979). Here, results fro...
5564
Background: Although the clinical application of PARP inhibitors (PARPis) has brought great survival benefits to patients with high-grade serous ovarian carcinoma (HGSOC), its resistance has gradually become a major challenge for clinicians with the widespread use of PARPis. Unfortunately, there are no effective, non-invasive means for monitor...
- [...]
5550
Background: Platinum-refractory or platinum-resistant ovarian cancer remains unmet medical need with an unfavorable prognosis. Its treatment options are limited and sequentially with multiple single-agent regimens or bevacizumab plus single-agent regimens are recommended. Mitoxantrone hydrochloride liposome (PLM60) is the first approved mitoxa...
2610
Background: Pre-clinical studies suggest synergistic activity of the combination of inhibitors of mTOR with a PD-1 antibody in solid tumors. Here we report initial results of a phase 1/2 open-label, dose escalation and expansion trial of the oral TORC1/2 inhibitor, onatasertib (ATG-008) in combination with toripalimab (tori), a PD-1 monoclonal...
5526
Background: The study (NCT03676959) is an open-label, phase I study investigating the safety and efficacy of the recombinant, fully human anti-programmed death-ligand 1 (PD-L1) monoclonal antibody socazolimab for recurrent or metastatic cervical cancer. Methods: Patients received socazolimab every 2 weeks until disease progression. The study w...
Introduction and hypothesis:
The aim of this study is to compare the perioperative, anatomical and functional outcomes of patients with Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS), undergoing Sheares vaginoplasty, vaginoplasty using acellular porcine small intestinal submucosa (SIS) graft or laparoscopic peritoneal (Davydov) vaginoplasty.
Met...
Background
Ovarian cancer (OC) patients benefited little from systematic pelvic/para-aortic lymph node dissection during surgery, which may attribute to the difficulties in identifying the patients with pelvic/para-aortic lymph node metastases (LNM) preoperatively. Unfortunately, risk factors predicting the pelvic/para-aortic LNM in OC patients are...
The communication between macrophages and tendon cells plays a critical role in regulating the tendon-healing process. However, the potential mechanisms through which macrophages can control peritendinous fibrosis are unknown. Our data showed a strong pro-inflammatory phenotype of macrophages after a mouse tendon–bone injury. Moreover, by using a s...
Background:
In patients with platinum-sensitive relapsed (PSR) ovarian cancer (OC), olaparib maintenance monotherapy significantly improves progression-free survival (PFS) versus placebo. However, evidence in the Asian population is lacking. This is the first study to evaluate olaparib efficacy and tolerability exclusively in Asian patients with P...
Background
This study aimed to evaluate the differences in cervical appearance among different human papillomavirus (HPV) genotypes in patients with high-grade squamous intraepithelial lesions (HSILs).
Methods
A total of 239 histopathological HSIL patients were included and divided into eight groups on the basis of HPV genotype in this prospective...
Background
Combination treatments with immune-checkpoint inhibitor and antiangiogenic therapy have the potential for synergistic activity through modulation of the microenvironment and represent a notable therapeutic strategy in recurrent ovarian cancer (ROC). We report the results of camrelizumab (an anti-programmed cell death protein-1 antibody)...
Background
Cancer stem cells (CSCs) are the root of human cancer development and the major cause of treatment failure. Aberrant elevation of SOX4, a member of SOX (SRY-related HMG-box) family transcription factors, has been identified in many types of human cancer and promotes cancer development. However, the role of SOX4 in CSCs, especially at a p...
Purpose
Early-stage cervical cancer is usually diagnosed by colposcopy-directed biopsy (CDB) and/or endocervical curettage (ECC), but some neglected lesions must be detected by conization because they are occult. This study aimed to explore the optimal method for detecting these “occult” cervical cancers.
Patients and Methods
A total of 1299 patie...
Minimal deviation adenocarcinoma (MDA) of uterine cervix is a rare malignant disease with rather poorer prognosis partially due to the early misdiagnosis. Hence, better understanding of early-stage symptoms is critical. We report a case of a 39-year-old woman came to hospital with a chief complaint of “a watery vaginal discharge for 9 months”. She...
High-grade neuroendocrine carcinoma of the uterine cervix (HGNECC) is a rare and overly aggressive malignancy. Due to its rarity, there is no standard treatment. A majority of early-stage patients receive radical hysterectomy and lymph node dissection (RH+LND), followed by adjuvant chemotherapy. To explore the most suitable methods of therapy, a mu...
Background
Lung cancer is the most prevalent cancer, and the leading cause of cancer-related deaths in China. The aim of this study was to estimate the direct medical expenditure incurred for lung cancer care and analyze the trend therein for the period 2002–2011 using nationally representative data in China
Methods
This study was based on 10-year...
Objectives
This sub-analysis investigated treatment response to niraparib maintenance therapy in patients with platinum-sensitive recurrent ovarian cancer (PSROC) included in the NORA trial who had measurable lesions after finishing chemotherapy and before initiating niraparib.
Methods
In the double-blind, phase III NORA trial, 265 adult (≥18 year...
Objectives
Anti-angiogenic therapy combined with chemotherapy could improve survival in patients with platinum-resistant ovarian cancer (OC). APPROVE was conducted to evaluate the efficacy and safety of apatinib, an oral tyrosine kinase inhibitor that selectively inhibits VEGFR-2, in combination with pegylated liposomal doxorubicin (PLD) in patient...
Background
This study aimed to evaluate the differences in cervical appearance among different human papillomavirus (HPV) genotypes in patients with high-grade squamous intraepithelial lesions (HSILs).
Methods
A total of 239 histopathological HSIL patients were included and divided into eight groups on the basis of HPV genotype in this prospective...
Purpose We aimed to validate the prognostic performance of the 2018 International Federation of Gynecology and Obstetrics(FIGO) IIIC staging system for patients with cervical cancer.
Methods We conducted a retrospective analysis of patients with stage III cervical cancer according to the 2018 FIGO staging system who received standardized treatment...
Background
Accurately forecasting the prognosis could improve cervical cancer management, however, the currently used clinical features are difficult to provide enough information. The aim of this study is to improve forecasting capability by developing a miRNAs-based machine learning survival prediction model.
Results
The expression characteristi...
Purpose
To evaluate the effectiveness and safety of pegylated recombinant human granulocyte colony stimulating factor (PEG-rhG-CSF) in preventing neutropenia during chemoradiotherapy in patients with cervical cancer.
Methods
From August 2018 to April 2020, 60 patients who were pathologically confirmed as cervical cancer were randomly divided into...
Purpose:
Fluzoparib (PARP inhibitor) showed promising anti-tumor activity for advanced ovarian cancer in a phase 1 study. This study aimed to assess the efficacy and safety of fluzoparib in patients with germline BRCA1/2-mutated recurrent ovarian cancer.
Methods:
This open-label, multi-center, single-arm, phase 2 study enrolled patients with pla...
IMPORTANCE Evidence is needed regarding the introduction of high-risk human papillomavirus (hrHPV) testing into China's national cervical cancer screening program. OBJECTIVE To evaluate hrHPV testing as a new screening modality for the national program. DESIGN, SETTING, AND PARTICIPANTS This population-based, multicenter, open-label, randomized cli...
Importance
Evidence is needed regarding the introduction of high-risk human papillomavirus (hrHPV) testing into China’s national cervical cancer screening program.
Objective
To evaluate hrHPV testing as a new screening modality for the national program.
Design, Setting, and Participants
This population-based, multicenter, open-label, randomized c...
Backgroud: Accurately forecasting the prognosis could improve therapeutic management of cancer patients, however, the currently used clinical features are difficult to provide enought information. The purpose of this study is to develop a survival prediction model for cervical cancer patients with big data and machine learning algorithms.
Results:...
Background: This retrospective multi-center study aimed to describe the epidemiological characteristics, clinical features, and management of patients with cervical cancer in pregnancy (CCIP) and evaluate maternal and infant outcomes.
Methods: The data of patients with CCIP were retrospectively collected from those diagnosed and treated in 17 hospi...
Epigenetic inactivation of GADD45A is a common occurrence in different types of cancer. However, little is known regarding its association with radiosensitivity in cervical cancer (CC). Thus, the present study aimed to investigate the association between aberrant GADD45A methylation and radiosensitivity in CC. SiHa, HeLa and CaSki CC cells were tre...
Background:
Human papilloma virus (HPV) infection is an important risk factor for vaginal intraepithelial neoplasia (VAIN). Recent studies have suggested that the microbiome may play a potential role in cervicovaginal diseases. This study aimed to explore the characteristics of the types and viral load of HPV in VAIN, as well as the association be...
Purpose
Maintenance therapy with the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib provided a substantial progression-free survival (PFS) benefit compared with placebo in patients with newly diagnosed advanced ovarian cancer and a BRCA mutation (BRCAm) who were in clinical complete or partial response following platinum-based chemotherapy i...
Doxorubicin (DOX) is currently one of the most widely used and effective drugs for the treatment of breast cancer, but drug resistance in breast cancer often leads to poor efficacy. MicroRNAs (miRNAs) are involved in the development and progression of various tumors and increasing number of studies have confirmed that abnormal miR-520b expression i...
An amendment to this paper has been published and can be accessed via the original article.
It has been demonstrated that microRNAs (miRNAs) act as oncogenes or tumor suppressors in a variety of cancers. Our previous work suggested that miR-10a/b functioned as a tumor suppressor in gastric cancer, and miR-10b was also reported to be significantly downregulated in advanced stage cervical cancer tissues. However, the aberrant expression of...
[This corrects the article DOI: 10.1186/s12935-019-1045-1.].
Purpose
This study aims to reveal the mechanism underlying baicalin-suppressing ovarian cancer stemness.
Methods
OVCAR-3 and the primary ovarian cancer cells were used for cell model. The ovarian cancer stem cells were isolated by suspension culture. Cell viability and clonogenicity were examined by CCK-8 assay and colony formation assay. The self...
Purpose
To evaluate the colposcopic accuracy of the detection of vaginal intraepithelial neoplasia (VaIN) according to the colposcopic terminology for the vagina from the 2011 International Federation of Cervical Pathology and Colposcopy (IFCPC).
Methods
A total of 467 women who were suspected of having VaIN and underwent colposcopy at Obstetrics...
The outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 has rapidly spread globally. Cancer patients are at a higher risk of being infected with the coronavirus and are more likely to develop severe complications, as compared to the general population. The increasing spread of COVID-19 prese...
It is urgent to develop an accurate approach to improve the predictive performance of hrHPV-based screening. The aim is to evaluate the performance of p16/Ki-67 and p16/MCM2 staining to triage high-risk human papillomavirus- (hrHPV-) positive women. Cervical specimens were collected from eligible women and tested for hrHPV genotyping, cytology, p16...
6032
Background: GLS-010 is a novel fully human anti-PD-1 mAb. Previous Phase I study exhibited favorable result of tolerance, preliminary efficacy and 240mg fixed dose q2w was selected as Recommended Phase II Dose (RP2D). This Phase II clinical trial is aimed to further evaluate the safety and anti-tumor activity of GLS-010 in patients with recurr...
Background:
We aimed to obtain a set of health state utility scores of patients with esophageal cancer (EC) and precancerous lesions in China, and to explore the influencing factors of health-related quality of life (HRQoL).
Methods:
A hospital-based multicenter cross-sectional study was conducted. From 2013 to 2014, patients with EC or precance...
Triple negative breast cancer (TNBC) is a devastating cancer disease characterized by its poor prognosis, distinct metastatic patterns, and aggressive biological behavior. Research indicates that the prevalence and presentation of TNBC varies among races, with Asian TNBC patients more commonly presenting with large invasive tumors, high node positi...
Introduction
The breast cancer stem cells contribute to the initiation, progression, recurrence, metastasis as well as resistance of breast cancer. However, the mechanisms underlying the maintenance of breast cancer stemness have not been fully understood.
Materials and methods
TCGA and GEO data were used for measuring miR-520b expression in breas...
Background:
Since FTO was recognized as the first m6A demethylase, the understanding of its biological function has been widely expanded. However, the role of FTO in cervical cancer tumorigenesis remains unclear.
Methods:
In this study, we first analyzed the expression of FTO in two independent human cancer datasets and evaluated the correlation...
Aim
To investigate the correlation between clinicopathological features and risk stratification in cervical cancer patients, and evaluate the feasibility of tumor-infiltrating immune cells as prognostic biomarkers in clinical practice.
Methods
CD3+ tumor infiltrating T cells (TILs), CD45RO+ TILs, CD4+ TILs, CD8+ TILs, FOXP3+ TILs (regulatory T cel...
Background
As part of China's 2009 health-care system reform, a national cervical cancer screening programme was launched, offering free screening by cytology or visuaI inspection with acetic acid and LugoI's iodine (VIA/VILI). We evaluated high-risk HPV (hrHPV) testing as a new screening modality for the national programme.
Methods
This multicent...
Objective:
The health-related quality of life (HRQoL) impacts of participating in breast cancer screening programmes is poorly understood.
Methods:
Based on the breast cancer screening programme, a multicentre cross-sectional survey was conducted covering 12 provinces from September 2013 to December 2014. HRQoL of participants in the screening p...
Increasing evidence has revealed the importance of microRNA (miRNA/miR) in cancer genesis and progression. The aim of the current study was to identify the key miRNAs involved in the onset and development of nasopharyngeal carcinoma (NPC) and to further evaluate their diagnostic and prognostic values. Microarray data were obtained and analyzed to s...
Introduction:
Cervical cancer rates in China remain high, with only limited opportunistic screening in urban centers and large mostly unscreened rural areas. Cervical cytology practices in China have been changing over the last decade with introduction of The Bethesda System reporting terminology, liquid-based cytology (LBC), and programs for cerv...
Background:
Increasing studies have identified a series of circulating mircoRNAs (miRNAs) as biomarkers for disease detection due to their stability in the blood. The aim of the present study was to identify specific plasma miRNAs as potential biomarkers for nasopharyngeal carcinoma (NPC) detection.
Materials and methods:
Relative public microar...
Na⁺/H⁺ exchanger isoform 1 (NHE1), which is a regulator of intracellular and extracellular pH via ion exchange, has been demonstrated to serve an important role in cell differentiation, migration and invasion in solid tumors and hematological malignancies. However, the potential role of NHE1 in epithelial ovarian cancer (EOC) remains unclear. In th...
Background:
In China, stomach cancer is the third most common cancer and the third leading cause of cancer death. Few studies have examined Chinese stomach cancer patients' medical expenses and their associated trends. The Cancer Screening Program in Urban China (CanSPUC) is a Major Public Health Project funded by the central government. Through t...
Long stress-induced noncoding transcript 5 (LSINCT5) is a member of the LSINCT family, members of which are expressed during stress-induced cell formation and have also been reported to promote cancer progression. In the present study, the association between LSINCT5 expression and clinical significance was investigated and the biological function...
The multi-center, randomized, open-label, phase III trial discussed in the present study was performed to compare the clinical outcomes of nedaplatin (NDP) plus paclitaxel, and carboplatin (CBP) plus paclitaxel for the treatment of epithelial ovarian cancer (EOC). In the current study, 182 patients with International Federation of Gynecology and Ob...
Objective:
This study aims to understand the medical expenditure for liver cancer during 2002-2011 in urban areas of China.
Materials and methods:
This is a retrospective study. Based on a stratified cluster sampling method, a medical expenditure survey collected basic personal information from related medical records. Two-tailed independent sam...
Background
In 2012, China's central government initiated the Cancer Screening Program in Urban China (CanSPUC). The aim of this study was, based on the CanSPUC, to assess the long-term sustainability of cancer screening in China.
Methods
This multicentre survey was conducted in 17 provinces across China between Oct 8, 2012, and Sept 15, 2015. 54 2...
Abstract Background The increasing prevalence of colorectal cancer (CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC diagnosis and treatment. We performed a survey to quantify the direct medical and non-medical expenditure as well as the re...
- [...]
Epithelial ovarian cancer remains the most common type of malignant tumor of the female reproductive system worldwide. Routine surgery and chemotherapy are the best treatments available for patients with ovarian cancer; however, almost 40% of ovarian cancer cases are intractable, with poor 5-year survival rates. MicroRNAs (miRNA) are endogenous sma...
Background: Studies on the association between spicy food intake and cancer risk have reported inconsistent results. We quantitatively assessed this association by conducting a meta-analysis based on evidence from case–control studies.
Methods: PubMed, EMBASE, and the Cochrane Library were searched for eligible publications. Combined odds ratios (O...
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Citations
... Currently, the standard therapeutic approach for several types of cancer is the administration of monoclonal antibodies (mAbs) designed to target PD-1 (pembrolizumab, nivolumab, cemiplimab, and dostarlimab) or PD-L1 (atezolizumab, avelumab, and durvalumab) [139][140][141][142][143][144] (Table 2). Also in China, the National Medical Products Administration (NMPA) has approved the anti-PD-1 toripalimab, sintilimab, camrelizumab, tislelizumab, and zimberelimab, and the Russian Ministry of Health authorized the manufacturing of prolgolimab, indicated for unresectable or metastatic melanoma [145][146][147][148][149][150]. ...
... and CTLA-4/B7.2. The a nity of Cadonilimab to lymphocytes in the tumor microenvironment is higher than that at peripheral sites, and it inhibits the binding of CTLA-4 in peripheral blood and normal tissues, reduces the toxic side effects caused by CTLA-4, and further improves the e cacy and safety of tumor immunotherapy [29]. Lenvatinib is a receptor tyrosine kinase(RTK) inhibitor that signi cantly inhibits Vascular endothelial growth factor(VEGF) and Fibroblast growth factor(FGF)-mediated signal transduction and doubly ghts tumor angiogenesis. ...
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... P > 0.05) [18] but were lower than those for Beijing (21.0%, χ2 = 20.4, P < 0.025) [19] and Zhejiang (27.3%, χ2 = 587.8, P < 0.001) [10]. ...
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... There is a minimum requirement for MI in animal cells [27,92], but elevated MI can act as a growth and cell-cycle suppressor. Exogenous application of MI or overexpression of MIB enzymes can have inhibitory effects on in vitro cultured cells [93][94][95]. Additionally, MI and it's derivative inositol hexaphosphate have well documented suppressive effects on cancer cell proliferation [96,97]. The proproliferative signaling pathways negatively affected by these molecules include PI3K/Akt, Wnt/β-catenin, and Notch1 [98,99]. ...
... According to WHO data, cervical cancer (Garcia-Becerra et al., 2023;Lindsay et al., 2022) is ranked fourteenth of all types of cancer and is ranked fourth for cancer in women throughout the world. (Fowler, Maani, Dunton, & Jack, 2022;World Health Organization, 2022) Based on data from the Organization World Health (World Health Organization / WHO) in 2020, there were around 604,000 new cases of cervical cancer (Laios et al., 2022;Yuan et al., 2023) from all over the world and around 342,000 deaths due to cervical cancer where around 90% of these deaths occurred in low to middle income countries. (World Health Organization , 2022) Meanwhile for the Asian continent, cervical cancer (Boyce-Fappiano et al., 2021;le Guyader et al., 2022;Li et al., 2021) is the third most common type of cancer found in women and is the main cause of cancer deaths in women in low to middle income countries. ...
... To date, the available evidence concerning the impact of debulking surgery on bulky lymphatic disease provides heterogeneous results, with some studies favoring the technique [44,45] and others providing evidence against it [43,46,47]. A prospective phase III randomized trial (CQGOG0103) will help provide more information on this group of patients; however, its results are not anticipated within this decade as the enrollment will last four years and the follow-up will be completed at five years [48]. ...
... A Chinese multicenter retrospective study suggested tumor diameter of >4 cm, LNM, DSI, and LVSI were confirmed as high-risk factors for worse DFS and OS in NECC patients. Patients with different numbers of risk factors had significantly different DFS and OS values [30]. In the current study, our prognostic model provided clinicians with an easy-to-use and quantitative tool to better scale the prognostic effect of those clinicopathologic factors on patients' survival. ...
... The overall response rates for PD-L1-positive and PD-L1negative patients were 16.7% and 17.9%, respectively. 70 Socazolimab with or without carboplatin plus etoposide is being evaluated in a Phase 3 multicenter, randomized, double blinded, placebo-controlled clinical trial (NCT04878016) as first-line treatment of patients with ES-SCLC. Enrollment for this study, estimated as 498 patients, has been completed. ...
Reference: Antibodies to watch in 2023
... 4,5 However, the current number of reports is limited, and furthermore, certain studies have drawn conflicting conclusions, necessitating further validation. [6][7][8] Therefore, it is crucial to accurately assess the primary tumor and lymph node (LN) status of these patients to differentiate tumor heterogeneity and plan individualized optimal treatment. 9 In this study, we evaluated the clinical outcomes and prognostic factors for 117 stage III C (FIGO 2018) cervical cancer patients treated with radical radiotherapy (RT) or radiochemotherapy at our department. ...
... GDF15 controls hematopoietic growth, energy homeostasis, adipose tissue metabolism, organismal growth, bone remodeling, and response to stress signals, and its role in cancer development and progression is complex [20]. Studies have shown that GDF15 can be used as a diagnostic marker for early-stage liver cancer [21,22]. BCAP31 is associated with the proliferation and metastasis of breast cancer, lung cancer and other tumors [23,24]. ...
