Qi Zhou's research while affiliated with Zhejiang University and other places
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Publications (6)
Objective
Autoimmune thyroid disease (AITD) is known to be associated with unexplained infertility in women. Although the presence of antithyroid antibodies have been speculated to be a marker of an immune imbalance that might lead to implantation failure, its underlying mechanism influencing the endometrial receptivity remains to be elucidated. In...
In efforts to explain how duplicate gene copies may rise to fixation in a population, previous models of new gene origination have under appreciated the importance of the 3D genome in this process. We show that positional effects on distally duplicated genes, i.e. enhancer capture, is an efficient mechanism for accommodation of new selective condit...
Chromatin states of genes and transposable elements (TEs) dictated by combinations of various histone modifications comprise key information for understanding the mechanisms of genome organization and regulation. However, little is known about the principles of their dynamic changes during development and evolution in a three-dimensional genome con...
The eukaryotic genome is packaged into transcriptionally active euchromatin and silent heterochromatin, with most studies focused on the former encompassing the majority of protein‐coding genes. The recent development of various sequencing techniques has refined this classic dichromatic partition and has better illuminated the composition, establis...
Citations
... Remarkably, natural selection has not purged the eukaryotic genome of this ostensibly useless DNA, suggesting that it might play a role in adaptation and speciation, for example, in consolidating reproductive isolation [14]. While non-coding DNA itself might be biologically inert, the heterochromatin that it forms plays a number of vital roles in transcription, DNA repair, DNA replication timing, and differentiation and development. ...
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