Pinyan Liu's research while affiliated with Lanzhou University and other places
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Publications (6)
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Background
The use of umbilical cord mesenchymal stem cells (UC-MSCs) is a burgeoning method for the treatment of liver cirrhosis. However, the secretory phenotype and regulatory ability of UC-MSCs are easily affected by their microenvironment. Ensuring a specific microenvironment to enhance the UC-MSCs phenotype is a potential strategy for improvi...
Androgenetic alopecia is the most common cause of hair loss aggravated by increased life pressure, tension, and anxiety. Although androgenetic alopecia (AGA) does not significantly effect physical health, it can have serious negative impact on the mental health and quality of life of the patient. Currently, the effect of medical treatment for AGA i...
Background
Solid tumors are stiffer than their surrounding normal tissues; however, their interior stiffness is not uniform. Under certain conditions, cancer cells can acquire stem-like phenotypes. However, it remains unclear how the heterogeneous physical microenvironment affects stemness expression in cancer cells. Here, we aimed to evaluate matr...
The tumor microenvironment (TME) is a complex macromolecular network filled with a series of stromal cells. It plays an important role in tumorigenesis, development, immune escape, drug resistance, and other processes and has received increasing attention in recent years. Currently, tumor cell-centered treatments are insufficient to eradicate malig...
Cost-effective treatment strategies for liver fibrosis or cirrhosis are limited. Many clinical trials of stem cells for liver disease shown that stem cells might be a potential therapeutic approach. This review will summarize the published clinical trials of stem cells for the treatment of liver fibrosis/cirrhosis and provide the latest overview of...
Pancreatic ductal adenocarcinoma (PDAC) one of the deadliest malignant tumor. Despite considerable progress in pancreatic cancer treatment in the past 10 years, PDAC mortality has shown no appreciable change, and systemic therapies for PDAC generally lack efficacy. Thus, developing biomarkers for treatment guidance is urgently required. This review...
Citations
... Stem cells are undifferentiated cells with an ability to self-renew and differentiate into several cell lineages to facilitate tissue repair and maintain homeostasis [53]. Stem cell therapy aims to reverse the pathogenesis of AGA, through stem cell transplants, stem cell derived conditioned media (CM) and exomes [54]. ...
... CSCs possess the functional characteristics of selfrenewal and differentiation and an augmented capacity for therapeutic resistance, immune evasion, invasion, and metastasis [50]. The stemness of tumor cells can be influenced by various factors, such as EMT, ECM, and various immune cells [51][52][53]. Our research indicated a potential association between PHLDA2 and the maintenance of stemness in HCC. ...
... It has been reported that the matrix hardness of myocardial cells adjacent to the hydrogel material changes after the hydrogel is injected into the ventricular wall (19)(20)(21). However, matrix hardness has been shown to alter various cellular behaviors (22)(23)(24)(25)(26), including the inflammatory phenotypes of various cells (27)(28)(29). Thus, we sought to analyze transcriptomic changes three days after the injection of alginate hydrogel into the infarcted ventricular wall following the early inflammatory response of MI to identify transcriptomes for a possible novel mechanism for cardiac function improvement. ...
... Moreover, their low intrinsic immunogenicity makes MSCs highly suitable for transplantation to treat various diseases [9], including acute and chronic liver diseases, anti-aging, cardiomyopathy, immune system diseases, metabolic syndrome, Alzheimer's disease, novel coronaviruses, and tumors [10][11][12]. Extensive evidence has demonstrated that MSC-based therapy for liver cirrhosis primarily targets anti-inflammatory and anti-fibrotic effects, as well as promoting liver repair through paracrine cytokines, immune regulation, and facilitation of extracellular matrix degradation via various signaling pathways, such as TGF-β1/SMAD, Wnt/β-catenin, Ras/ERK, or Notch [13][14][15][16][17][18]. Presently, the transplantation of MSCs for the treatment of liver cirrhosis has been registered and its therapeutic effect has been verified in numerous clinical trials [19][20][21]. ...
... Compared to genetically engineered mouse models, PDOs are less time-consuming and costly, can be constructed from small amounts of material obtained from fine-needle biopsies, and can be generated from patients whose tissues are difficult to resect [46]. Therefore, this method provides more accurate results and more effective drug screening than genetically engi-neered mouse models and can be used in precision medicine [47]. In particular, organoids can be established in resected tissues before chemotherapy or after neoadjuvant chemotherapy to measure the response to anticancer drugs, which is useful for precision therapy, drug screening, and tumor biology research [48]. ...
