Piet Pattyn's research while affiliated with Universitair Ziekenhuis Ghent and other places

... Previously, data from the first phase of the OptiLUTS part C trial were published. 11 This manuscript is the report of the final data analysis of longitudinal objective and subjective outcome measures up to 12 months follow-up, stratified by medical department. Approval was obtained from the ethics committee of the University Hospital of Ghent (EC/2018/0244). ...

... Variations in the definition of FTR have been widely acknowledged, 5,10 with studies using 30-day mortality, 90-day mortality, survival to discharge or a combination of these within their definition of FTR. 2,3,5,11,12 The NSQIP data used was somewhat limited by the recording of only 30-day mortality; as such assessment of mortality beyond 30 days was not possible. This aside, multiple population based international studies report FTR rates following oesophagectomy in excess of 15% 3,13 and so 6.3% does seem acceptable, particularly considering the lower volume of oesophagectomy performed within Australian centres. 1 There was marked variation in caseload both between hospitals and for individual hospitals year-on-year. ...

... Failure of the anastomosis is caused by a variety of risk factors. Among these multiple risk factors, some of the most important are the preoperative nutritional status and presence of pre-existing metabolic diseases, as well as the pre-and perioperative management strategies, such as preoperative rehabilitation [16]. Another important patient-specific factor is the presence of a small stomach, which makes it difficult to create a long enough gastric tube [17]. ...

... The COVID-19 pandemic caused severe disruptions in surgical activity worldwide, with an estimated 28.4 million cancelled elective operations. [23] By rationing and prioritizing surgical procedures, global policies and recommendations aimed primarily to rationalize health care resources -both in terms of preserving bed, intensive care, and operating room capacities, and of protecting healthcare workers from SARS-CoV-2 infection. [24,25] A further concern was the high rate of mortality and respiratory complications observed in patients infected with SARS-CoV-2 undergoing surgery. ...

... After rectal cancer patients received anal-saving surgery or reversal of temporary stoma, they experienced varied symptoms of altered bowl function [20][21][22]. They were often preoccupied with these uncontrolled excrement symptoms, which easily disturb their physical function, compel them to experience emotional distress, and interfere with their social activities [7,[20][21][22][23][24]. Additionally, a multicenter correctional study revealed patients with the major low anterior resection syndrome had significantly worse quality of life than the those with minor and moderate syndrome [25]. ...

... CTCs shed and relocate at a new site, in a process often referred to as tumor metastasis [5]. In recent decades, the CTCs in peripheral blood have been demonstrated to be a diagnostic biomarker and prognostic factor and offer new strategies for treating cancer, especially lung cancer [6]. For ESCC patients, CTCs were explored as a biomarker for diagnosing, staging and evaluating treatment efficacy [7][8][9][10]. ...

... Symptomatic hiatal hernia recurrence risk was not statistically different in those with and without a fundoplication from the analysis of two RCTs [52,54] (RR = 0.55, 95%CI 0.20, 1.51; I 2 = 0%) and four observational studies [23,50,53,56] (RR = 0.99, 95%CI 0.32, 3.13; I 2 = 51%) (Fig. 6a). Radiographic recurrence risk was found to be not statistically different in one RCT [54] (RR = 0.50, 95%CI 0.14, 1.76). ...

... 6 To overcome this problem, Schuring et al. 6 proposed one uniform TIGER-study classification system with defined anatomic landmarks based on the 11th edition of the 'Japanese Classification of Esophageal Cancer' (JES) and the 8th edition of the 'American Joint Committee on Cancer/Union for International Cancer Control' (AJCC/UICC) classification. 7 Even when consensus has been reached on which LNSs to dissect (the extent of LND), it is expected that discrepancies remain in the definition of anatomic boundaries of each LNS. This became apparent during the development of the procedure-specific competency assessment tool (MIE-CAT) by Ketel et al. 8 to assess the surgical performance of minimally invasive esophagectomy (MIE) and to determine where most discrepancies were present in assessing the LND phases during MIE. ...

... The impact of esophageal cancer surgery complications on survival remains an acute issue discussed in a few publications. Some studies have shown a significant effect of postoperative complications on a decrease in survival [3][4][5][6], while others have not proven this pattern [7,8]. ...

... Group A (Op): laparotomy with colonic anastomosis only. Group B (Op + AdMSCs): laparotomy with colonic anastomosis and local injection of 5 × 10 6 AdMSCs in 70 µL power buffer saline (PBS) [34,43,44]. Group C (Op + DSS + Sal): DSS 5%, laparotomy with colonic anastomosis, and local injection of 70 µL power buffer saline (PBS). ...