Pierre Potier's research while affiliated with University College London and other places

... 27 Importantly, cotreatment with Ac-SDKP increased survival in mice given a lethal dose of cyclophosphamide, enabling higher doses of chemotherapeutic agents to decrease tumour size without causing death. 28,29 In addition, Ac-SDKP was shown to inhibit proliferation of normal progenitor cells, but not already committed leukaemic cells, 30,31 raising expectations that elevated Ac-SDKP levels could serve as a useful adjunct to lower chemotherapeutic-associated morbidity by keeping progenitor cells in the quiescent state during treatment. ...

... N-(t-butoxycarbonyl)thiourea [16] (2.90 g, 16.5 mmol) was added to solution of thioester 21 (2.96 g, 16.2 mmol) in isopropanol (30 ml) and stirred at 0 • C, then allowed to regain room temperature. After 16 h, an almost clear pale yellow solution had formed; freshly activated 4Å molecular sieves (1 g) were added and stirring continued for another 24 h. ...

... The formation of ester (5) can be explained if we take into account that the acidity of PCC can promote a rapid addition of 1,2-diacetin (2) to the glyceraldehyde diacetate (3) to form the dimeric hemiacetal (4), from which subsequent oxidation produces the dimeric ester (5) (Figure 3) [77][78][79]. To assess the effect of acetonitrile on the hydrolysis of triacetin by CALB-OC and to improve the solubility of triacetin, we evaluated the addition of 20% acetonitrile to the reaction mixture. ...

... From literature survey, it was found that aminothiazoles proved to have a broad spectrum of activity against most of the tested subpanel tumor cell lines [27e 31]. In addition, 2-aminothiazole analog of the natural cytotoxic agent, girolline, [32] and cantharidin [33] demonstrated increased apoptotic activity compared to their parent compounds. Furthermore , several reports indicated that series of 2-amino-4- arylthiazoles were synthesized and reported to be active as anticancer agents [34e37]. ...

... Numerous pyridine compounds showed impressive anticonvulsant properties. [141] Novel quinoxaline compounds 73 a-v ( Figure 19) that are connected to a pyridine moiety by phenyl-amino or phenoxy residues were created and tested as potential anticonvulsants by Nasr et al. [142] Three dose levels of the substances 30, 100, and 300 mg/kg were administered intraperitoneally to albino mice using this approach. Numerous compounds showed prominent anticonvulsant properties. ...

... Citral is a central compound in the fragrance and flavour industry and is crucial for the production of other fragrances and drugs. 381,382 Although citral is the principal constituent (75-85%) of the oil of lemongrass, 383 it is currently mainly produced from isobutene and formaldehyde, derived from fossil fuels. 384 It has a strong lemon-like odour, a bittersweet taste, and the commercial product is a mixture of geranial and neral geometric isomers. ...

... This serendipitous discovery led to the development of a new ring-expansion methodology and served for the elaboration of heavily substituted sixand seven-membered rings from simple and well known building blocks in a limited number of synthetic opera- tions. 3 A series of experiments were then addressed to better understand the factors involved in these cascade transformations such as the influence of solvent 4 and substitution pattern. 5 To gain insight into the mechanistic course and eventually extend the scope of the process, it was essential to this study that some other oxidants in various solvents were employed. ...

... Biological studies showed great numbers of substituted imidazoles with wide spectrum of 32 biological activities, such as antitumor, antimicrobial, anti-HIV, antibacterial, antihypertensive, antifungal and 33 anticonvulsant activity. [1][2][3][4][5][6] Imidazole nucleus and its derivatives are considered as privileged scaffold in 34 medicinal chemistry, they constitute an important class of therapeutic agents and well known as drugs. For 35 example; Dacarbazine (DTIC) (5-(3,3-dimethyl-1-triazeno)imidazol-4-carboxamide was synthesized as an 36 alkylating agent 7 and used in the treatment of metastatic melanoma 8,9 as well as a part of the ABVD 37 chemotherapy regimen to treat Hodgkin's lymphoma 10,11 and in the MAID regimen for sarcoma. ...

... Another strategy introduces the nitrogen at C-2 [11] via the 2-iodoxybenzoic acidmediated generation of an oxazolidinone ring, selectively leading to C 2 -C 3 syn-products [12]. A third approach features E-selective Julia olefination of (R)-or (S)-2,3-isopropylideneglyceraldehyde with a second chiral building block containing the amine function, followed by dihydroxylation [13,14]. Despite the compounds already available through these and other approaches, novel synthetic concepts to fill the remaining methodological gaps for accessing the missing isomers of 2-amino sugars, as well as new derivatives are still highly desired. ...

... Sasaki et al. reported a stereocontrolled synthesis of 2,5disubstituted pyrrolidines by reacting two chiral starting materials, a glycerol-derived bistriflate 63 and an aminosulfone 62 (Scheme 11). 31 ...