Philippe Birembaut's research while affiliated with Université de Reims Champagne-Ardenne and other places

... For that purpose, we first examined the SWATH-MS proteomic data of the whole biocollection of rat mesothelial cell lines, looking in particular at the list of 674 proteins differentiating preneoplastic cell lines with sarcomatoid versus epithelioid morphology [18]. In a second step, we compared this list to another list of 192 proteins discriminating the two subgroups of preneoplastic cell lines with sarcomatoid morphology PNsarc2 vs. PNsarc1, which differ in their relative expression of Hif1a [18]. Finally, comparing the 94 proteins exhibiting significant abundance changes in the two previous situations with the 28 candidate biomarkers described above (see Figure 2D and Sections 2.2 and 2.3), led to six proteins common to the four proteomic analyzes ( Figure 6A). ...

... Only by realizing early diagnosis of central lung squamous cell carcinoma and squamous cell epithelial precancerous lesions can timely and reasonable treatment be carried out. Meanwhile, if the squamous epithelial precancerous lesions can be treated by minimally invasive treatment technique under bronchoscopy before they progress into squamous cell carcinoma [19][20], the prognosis of patients will be further improved [21][22]. ...

... In other studies, good concordance between the presence of viral transcripts and high VL was observed for identifying HPV16-related tumors in OPSCC patients [23]. In contrast, in one study, neither VL nor HPV16 DNA integration was associated with OS or PFS [27]. In our research, the plasma-based VL was not related to OS or LRFS (p = 0.70 for both, Table 3). ...

... It has been proven to be a risk factor for nicotine dependence and SZ [63][64][65]. In transgenic rodents, this α5SNP contributed to increased nicotine intake and the generation of Chronic Obstructive Pulmonary Disease (COPD)-like lesions [39, 66,67]. In vitro data suggests that the α5SNP results in a partial loss of function in nAChRs when co-assembled [68][69][70], but genotype-dependent differences in the electrophysiological properties were not observed between WT and α5SNP rats. ...

... As COPD begins with small airway dysfunction our study focused on changes in the small airways and airway epithelium in COPD. The mechanism by which CS promoting EMT in airway epithelial cells is also under study, which may involve the TGF-β/Samd [43], WNT/ β-catenin, Hedgehog (Hh) [44], urokinase plasminogen activator receptor (uPAR) [45], and Notch signaling pathways [46]. Among them, the TGF-β/Samd pathway has been relatively studied. ...

... [5] A growing number of patients potentially benefit from the HER2-targeted therapies which have become an indispensable method in present breast cancer treatment. Besides, HER2-targeted therapies also develop in other tumors such as gastric, colon or biliary malignant cancer [6]. Regarding lung cancer, HER-2 mutations and HER-2 amplification have been considered as carcinogenic factors and potential therapeutic targets [7]. ...

... Recently, VIM has emerged as a critical player in the post-transcriptional regulation of speci c mRNAs, demonstrating the ability to interact with both the 3'-untranslated region (3'-UTR) and 5'-untranslated region (5'-UTR) of these molecules (7,8). These ndings suggest that VIM plays a pivotal role in the transcriptional regulation of mRNAs, potentially in uencing the metastatic capability and progression of cancer cells. ...