Petra Barros dos Santos's research while affiliated with Federal University of Pernambuco and other places
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Publications (6)
Mammary carcinoma is the most common malignant tumor in women, and it is the leading cause of mortality. In tumor context, glycosylation promotes post translational modifications necessary for cell progression, emerging as a relevant tumor hallmarker. This study aimed to analyze the association between polypeptide N-acetylgalactosaminyltransferase-...
Hypoxic areas in solid tumors are often associated with poor prognosis and resistance to chemotherapy. The aim of the study was to analyze the expression of galectin-1 (Gal-1), galectin-3 (Gal-3), sialic acid and b1-6 branched glycan structures in hypoxic environment of invasive ductal carcinoma (IDC) of the breast. We performed lectin histochemist...
Background
The main focus of several studies concerned with cancer progression and metastasis is to analyze the mechanisms that allow cancer cells to interact and quickly adapt with their environment. Integrins, a family of transmembrane glycoproteins, play a major role in invasive and metastatic processes. Integrins are involved in cell adhesion i...
Environmental stresses such as drought and salinity limit crop productivity in worldwide level. These stresses often lead
to the accumulation of osmoprotectants in most organisms, including plants. In the present work, a search of known osmoprotectants
(P5CS, P5CR, INPS1, BADH, CMO, TPS, TPP, OASTL and SAT) was carried out in the sugarcane transcri...
Nodulin genes have been defined as plant genes that are induced during nodule formation in legumes. Many studies, however,
revealed a number of nodulins in non-legumes, including monocot plants, suggesting that these genes play additional roles
besides nodulation. The presence and expression profile of the early nodulin genes (Annexin, DMI3, NIN, N...
Citations
... Immunohistochemical studies performed by our group showed that Gal-3 expression, in invasive and in situ ductal carcinoma of breast, was significantly higher among those with hypoxic regions. We also observed that Gal-1 expression was found mainly in the extracellular matrix and tumor-associated stromal cells, demonstrating their importance in the relationship between a tumor and its microenvironment [226,227]. ...
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... When the salt stress were given to plants there was a downregulation in all these genes and indicating that sugarcane response differently to different kind of stress (Patade et al. 2012). Transcriptome studies of sugarcane reported that during stress conditions plant accumulate osmoprotectants and 56 clusters of candidate gene classified to osmoprotectant were upregulated (Dos Santos et al. 2011). ...
Reference: Sugarcane Genomics and Transcriptomics
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... Based on these considerations, we concluded that ITGB1 would provide a better association with chemoresistance in breast cancer and a test of our CPB strategy. Previous studies have associated ITGB1 with breast cancer survival, proliferation, and poor outcome [53][54][55]. A study by Park et al. previously established the prominent role of ITGB1 in radioresistance in breast cancer [56]. ...
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