Petr Dytrych's research while affiliated with Charles University in Prague and other places
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Publications (7)
Background and Objectives: Insulinoma is a rare tumor of the Langerhans islets of the pancreas. It produces insulin and causes severe hypoglycemia with neuroglycopenic symptoms. The incidence is low, at about 1–2 per 1 million inhabitants per year. The diagnosis is based on the presence of Whipple’s triad and the result of a fasting test. Surgery i...
Background Opioids and epidural analgesia are a mainstay of perioperative analgesia but their infuence on cancer
recurrence remains unclear. Based on retrospective data, we found that cancer recurrence following colorectal cancer
surgery correlates with the number of circulating tumor cells (CTCs) in the early postoperative period. Also, morphine...
Proton pump inhibitors, such as omeprazole, pantoprazole and lansoprazole, are an important group of clinically used drugs. Generally, they are considered safe without direct toxicity. Nevertheless, their long‐term use can be associated with a higher risk of some serious pathological states (e.g., amnesia and oncological and neurodegenerative state...
Background:
Peritoneal carcinomatosis of gastric origin is challenging to diagnose and treat. This disease is often misdiagnosed in the early stages using a non-invasive technique. Conventional surgery is unsuitable for treatment of patients with peritoneal seeding and positive peritoneal cytology. Peritoneal recurrence is the most frequent cause...
This article provides an introduction to peritoneal tumors, which are the subject of a series of review papers published in Issue 5 (2019) of Klinicka onkologie. Many malignant peritoneal tumors are characterized by production of mucinous and gelatinous masses, multiple peritoneal disability, so-called peritoneal carcinomatosis, and various grades...
Gastric cancer is a common oncological disease. Although enormous efforts have been expended, possible therapeutic modalities are still limited. For this reason, new therapeutic approaches and agents are highly requested and intensively developed. One strategy is the application of natural agents, such as curcumin, with proven anticancer effects an...
Introduction
Peritoneal tumor seeding is a common form of recurrence after gastric cancer surgery. The finding of free tumor cells and/or elevation of tumor markers in the peritoneal fluid could predict intraperitoneal tumor recurrence. The results of these examination can be used for indication of aggressive treatment modalities such as hypertherm...
Citations
... These tumors are associated with significant complications, with an occurrence rate of approximately 45-52%, similar to other pancreatic surgeries. Furthermore, a lower incidence of complications is observed in patients already hospitalized or with longterm coexistence with the disease (Hoskovec et al., 2023). ...
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... Conditional constants (K values) were calculated from the absorbance changes (∆A) of tryptanthrin derivates and their complexes with Cu(II), Fe(II) and Fe(III) ions at their spectral maximum by regression analysis (Letagrop Spefo 2005 software). The details of computational model have been described and discussed by Silen et al. [28], and the same method was used to analyse the binding affinity of the organic receptors for metal ions in aqueous media [29][30][31][32][33][34][35][36]. Solutions were mixed in the cuvette during the whole titration and after each addition of metal guests. ...
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... For GA patients with PMs, systemic chemotherapy or optimal supportive care is recommended by current National Comprehensive Cancer Network (NCCN) guidelines (6). However, although chemotherapy can achieve remission, resistance usually develops within 6 months because of the plasma-peritoneal barrier between mesothelial cells and mesangial capillaries (7,8). Surgery is usually not the first option for these patients because of the poor prognosis. ...
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... Currently, it cannot be ruled out that the long-term consumption of curcumin in various forms can cause anemia. On the other hand, higher iron levels are often associated with carcinogenesis, and the possibility of using iron chelators is being intensively studied in the therapeutic approach to cancer treatment, including in patients with gastric adenocarcinoma [174,175]. Curcumin can interact with many proteins, which may lead to both pharmacological benefits and may cause unwanted side effects such as the induction of gallbladder contraction (20-40 mg), decreased chemical sensitivity [176], and abdominal pain (200 mg) [177]. The most common side effects of curcumin are nausea and diarrhea [178]. ...
... Thirteen patients experienced reduced ascites production, usually after the first PIPAC. This is probably common in both intraperitoneal chemotherapies (HIPEC and PIPAC) [23][24][25]. On the other hand, two patients were without ascites, or with a small amount of it, but they developed ascites during treatment. ...
