Peng Zhou's research while affiliated with Shandong Normal University and other places
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Publications (10)
Despite the importance of cilia in cell signaling and motility, the molecular mechanisms regulating cilium formation remain incompletely understood. Herein, we characterize enkurin domain-containing protein 1 (ENKD1) as a novel centrosomal protein that mediates the removal of centriolar coiled-coil protein 110 (CP110) from the mother centriole to p...
Background
Auditory neuropathy is a cause of hearing loss that has been studied in a number of animal models. Signal transmission from hair cells to spiral ganglion neurons plays an important role in normal hearing. CYLD is a microtubule‐binding protein, and deubiquitinase involved in the regulation of various cellular processes. In this study, we...
Exposure of mucosal epithelial cells to the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 is known to disrupt epithelial cell junctions by impairing stathmin-mediated microtubule depolymerization. However, the pathological significance of this process and its underlying molecular mechanism remain unclear. Here we show that...
Non‐small cell lung cancer (NSCLC) is the most common cause of cancer mortality worldwide. NSCLC has an aggressive phenotype and poor prognosis, and is quite heterogeneous without effective and specific targeted therapies. Therefore, exploring new tumor markers and drug targets for NSCLC is crucial towards individualized treatment. Here, we demonst...
Background
Diffuse large B‐cell lymphoma (DLBCL) is the most common category of non‐Hodgkin lymphoma (NHL). However, the underlying molecular mechanism of DLBCL remains unclear.
Methods
Real‐time PCR and Western blot analysis were performed to assess the expression of ubiquitin‐specific peptidase 21 (USP21) or enhancer of zeste 2 polycomb repressi...
Ubiquitin‐specific protease 21 (USP21) has been implicated in several types of cancer. It promotes or suppresses tumor growth in a cell‐context dependent manner. Cholangiocarcinoma is a malignant tumor with a high mortality rate. However, the role of USP21 in cholangiocarcinoma remains unknown. Here, we identify that the level of USP21 is upregulat...
Cytoskeletal proteins are susceptible to glutathionylation under oxidizing conditions, and oxidative damage has been implicated in several neurodegenerative diseases. End-binding protein 1 (EB1) is a master regulator of microtubule plus-end tracking proteins (+TIPs) and is critically involved in the control of microtubule dynamics and cellular proc...
Primary cilia are microtubule-based cellular structures located on the surfaces of most mammalian cells and play important roles in detecting external stimuli, signal transduction, and cell cycle regulation. Primary cilia are also present in several structures of the eye, and their abnormal development or dysfunction can cause various ocular diseas...
Retinopathy of prematurity (ROP) is a leading cause of childhood blindness. However, the pathogenesis and molecular mechanisms underlying ROP remain elusive. Herein, using the oxygen-induced retinopathy (OIR) mouse model of ROP, we demonstrate that disassembly of photoreceptor connecting cilia is an early event in response to oxygen changes. Histon...
The tumor suppressor protein cylindromatosis (CYLD), as a microtubule-associated deubiquitinase, plays a pivotal role in a wide range of cellular activities, including innate immunity, cell division, and ciliogenesis. Structural characterization reveals a small zinc-binding B-box inserted within the ubiquitin specific protease (USP) domain of CYLD;...
Citations
... ENKD1 also acts as a positive regulator of ciliary length and Hh signaling (Tiryaki et al., 2022). Besides binding and stabilizing microtubules, ENKD1 competes with CEP97 for binding to CP110, facilitating axonemal assembly (Song et al., 2022). Conversely, MAP4, a member of the Tau protein family, is a negative regulator of cilium length; it localizes to axonemes and preferentially restricts growth in the ciliary distal segment relative to that in the proximal, highly polyglutamylated region (Ghossoub et al., 2013;Kanamaru et al., 2022). ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1004071494377474-1616400707713_Q64/Yunfan-Yang-2.jpg)
... This observation serves to validate the neurotoxic impact of PTX on PC12 cells ( Figure S2B, Supporting Information). [52,53] Accordingly, it was decided to conduct an additional experiment using 10 μM PTX, and the differentiated cells were treated with 10 μM PTX and AR extract, PLGA/AR NPs, and HA-PLGA/AR NPs, respectively. In the case of AR extract and AR PLGA NPs, neurites were about twice as long as when treated with 10 μM PTX and measured about 30-40 μm. ...
... The intricate process of post-translational modifications such as arginine methylation significantly expands proteomic diversity and regulates many essential, dynamic cellular processes [25][26][27][28][29][30]. Arginine methylation, a prevalent post-translational modification in eukaryotes, is implicated in DNA repair, transcription, receptor trafficking, and the stabilization of proteins [31]. ...
... Furthermore, although there is no direct evidence of their association with PDAC, high expression of CARHSP1 [54], TTYH3 [55,56], RPL35 [57], ANPEP [58], UBE3A [59], and UBE2H [60] have been reported in various types of cancer and are significantly related to poor overall survival. Conversely, ENKD1 [61], ACO1 [62], SEL1L3 [63], and SEMA6D [64] were observed to be associated with prolonged overall survival. These studies highlight the potential significance of these genes in the context of PDAC prognosis and offer avenues for further research on therapeutic interventions and precision medicine strategies for PDAC. ...
... It was shown that the deubiquitinating activity contributed to maintaining EZH2 protein level leading to tumor proliferation and metastasis. 59,60 USP36. The DUB USP36 has been implicated in a range of disease processes, including cancer. ...
... In addition, USP21 has also been reported to promote tumorigenicity in mesenchymal glioblastoma stem cells by deubiquitinating FOXD1 [9]. Although it has been reported that USP21 expression is upregulated in cholangiocarcinoma [10], the mechanism of USP21 in the progression of CCA has not been studied. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/291989217136649-1446627063109_Q64/Songbo-Xie.jpg)
... Our understanding about the pathogenesis of tubulinopathies is further hampered by our limited knowledge on tubulin and microtubule regulatory mechanisms at the transcriptional, translational and post-translational level ( Figures 1A, B). Many of these mechanisms have recently emerged e.g., the modulation of microtubule polymerization by glutathionylation (Chen et al., 2021) but their biological significance is not yet full understood thus making it difficult to faithfully predict the effects of tubulin mutations on microtubule function. ...
... The beating motion in such motile cilia typically takes place via time-periodic bending of rod-like axonemes, which are in turn powered by dynein motor proteins sliding between axonemes 84 . Nonmotile primary cilia, in which no autonomous motion is present, can play an important role in detection of external stimuli in human eyes 135 . Hydrodynamics of long polymer chains and their interaction with gel pores determine separation of DNA molecules via electrophoresis 95,125 . ...
... However, VHL recognizes and ubiquitinates UBE3B in a PHD-independent manner. This strengthens the understanding that VHL can ubiquitinate proteins independently of PHDs and oxygen, as seen with AURKA (Aurora A kinase) and HDAC6 (Histone Deacetylase 6) [46,47]. HIF-1α mainly responds to acute or transient hypoxia, while HIF-2α plays a dominant role in chronic hypoxia [48]. ...
... Importantly, a patient with the Leu72!Pro missense mutation in the HOIP PUB domain reportedly exhibited m u l t i o r g a n a u t o i n fl a m m a t i o n , i m m u n o d e fi c i e n c y , amylopectinosis, and lymphangiectasia with impaired distributions and functions of T lymphocytes (41), suggesting that the effects of the mutation may be due to the dysfunctional binding of LUBAC to the CBM complex. Importantly, the B-box domain in CYLD is involved in the intermolecular interaction (42), and the B-box-containing region in HOIP reportedly affected the dimerization of HOIP (16). Therefore, the deletion of this region may affect the architecture of LUBAC, resulting in defective CBM complex binding. ...
