Peng Shao's research while affiliated with First Affiliated Hospital of China Medical University and other places
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Publications (2)
Despite recent improvements in the comprehensive therapy of malignancy, metastatic colorectal cancer (mCRC) continues to have a poor prognosis. Notably, 5% of mCRC cases harbor Erb-B2 receptor tyrosine kinase 2 (ERBB2) alterations. ERBB2, commonly referred to as human epidermal growth factor receptor 2, is a member of the human epidermal growth fac...
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths globally. Metastasis is associated with a poor prognosis, yet the underlying molecular mechanism(s) remained largely unknown. In this study, a total of 85 CRC patients were included and the primary tumor lesions were evaluated by next-generation sequencing using a targete...
Citations
... HER2 activates several downstream signaling mediators that regulate cell growth and proliferation. By nurturing these pathways, HER2 signaling can promote tumor growth, angiogenesis, and metastasis [16]. For example, the overexpression of HER2 has been connected with chemoresistance via mechanisms that include the activation of HER2-dependent signaling pathways [17]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/279804420083712-1443721980016_Q64/Liu-Yang-47.jpg)
... For patients with advanced CRC, the efficacy of chemotherapy is affected by drug resistance and serious adverse reactions, and the overall treatment effect remains unsatisfactory. As a major threat to human health, CRC management is a significant challenge in the field of cancer research [6,7]. Elucidation of the molecular mechanisms underlying its pathogenesis and identification of effective Ivyspring International Publisher disease-targeting molecules with minimal side-effects are essential research goals for early diagnosis and treatment. ...
