Paul P. Carbone's scientific contributions

Three patients with cardiomegaly, congestive cardiac failure and blood eosinophilia are described. Necropsy in two disclosed severe mural endocardial fibrosis with superimposed fibrin-platelet thrombi, myocardial scarring, eosinophilic hyperplasia of the bone marrow and spleen without abnormal or leukemic myeloblasts, and occasionally thrombosed small arteries in the heart, spleen, kidneys and lungs. These features are similar to those described in patients with Löffler's fibroplastic parietal endocarditis and in “eosinophilic leukemia” without abnormal myelopoiesis. It is suggested that these two conditions are the same disease. It is also suggested that the predominantly African condition, endomyocardial fibrosis without eosinophilia, may be a late or inactive stage of either Löffler's endocarditis or of “eosinophilic leukemia” without abnormal myelopoiesis.

Three patients with cardiomegaly, congestive cardiac failure and blood eosinophilia are described. Necropsy in two disclosed severe mural endocardial fibrosis with superimposed fibrin-platelet thrombi, myocardial scarring, eosinophilic hyperplasia of the bone marrow and spleen without abnormal or leukemic myeloblasts, and occasionally thrombosed small arteries in the heart, spleen, kidneys and lungs. These features are similar to those described in patients with Löffler's fibroplastic parietal endocarditis and in “eosinophilic leukemia” without abnormal myelopoiesis. It is suggested that these two conditions are the same disease. It is also suggested that the predominantly African condition, endomyocardial fibrosis without eosinophilia, may be a late or inactive stage of either Löffler's endocarditis or of “eosinophilic leukemia” without abnormal myelopoiesis.