Paul M. Ryan's research while affiliated with University of Nevada, Reno and other places

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Publications (35)


Single-Lateral-Incision Technique for Talar Neck Fractures—A Viable Option
  • Article
  • Full-text available

October 2023

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9 Reads

Osteology

Paul M. Ryan

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Jacob Arthur

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Keanu McMurray

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Background: Displaced talar neck fractures are subject to avascular necrosis and degenerative joint disease. A single-lateral-incision approach may avoid damage to the remaining blood supply to the talar body provided by the deltoid artery. The purpose of this paper is to describe the surgical technique for a single approach to talar neck fractures, to evaluate the outcomes in a cohort of patients, and to review the literature on the topic. Method: A retrospective review. Patients were identified at a single medical center and met the following inclusion criteria: closed fracture, type-II talar neck fracture with displacement of the subtalar joint, single lateral operative approach, and radiographic follow-up of at least 6 months. Results: Five patients were identified meeting the inclusion criteria. The mean follow-up was 18 months (12–25). The mean VAS (Visual Analog Score) score at the final follow-up was 1.2 (0–3). Four of five patients returned to running at the final follow-up. The one patient who did not return to running was able to bike and hike. There were no cases of avascular necrosis and no cases of degenerative joint disease. Conclusions: Although a two-incision approach could be considered for all displaced talar neck fractures, there are certain fractures that can be anatomically reduced and stabilized through a single lateral incision which may limit the risk of avascular necrosis.

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Figure 1. Initial AP pelvis radiograph on presentation demonstrating a 5.0 cm separation of the pubic symphysis and anterior widening of the sacroiliac joint.
Figure 3. Follow-up AP pelvis radiographs (a) 3-week post-injury AP pelvis radiograph; (b) 3-month post-injury AP pelvis radiograph; (c) 6-month post-injury AP pelvis radiograph.
Diagnosis and Management Controversies Illustrated by an Uncommon Case of Postpartum Pubic Symphysis Diastasis

September 2023

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20 Reads

Osteology

Pubic symphysis diastasis is a complication of pregnancy that can lead to prolonged recovery, persistent pain, and functional disability if managed inappropriately. There is a lack of universally accepted clinical guidelines with regards to the timeframe and defect criteria for surgical management, which contributes to delayed care resulting in increased surgical complexity and subsequent impairments in functionality and quality of life. The current standard of care utilizes non-operative measures exclusively for separations measuring less than 2.5 cm correlating to symphyseal ligament sparing. Surgical interventions are typically reserved for severe cases or those resistant to initial non-operative treatment. Non-surgical methods have been attempted for 4–6 weeks, even in severe cases, with patients still requiring eventual surgery. We herein report an uncommon case of pubic symphysis diastasis measuring 5.5 cm and the successful implementation of non-surgical management to demonstrate the need for updated standardized treatment guidelines. The defect in this case was treated with early application of a pelvic binder resulting in anatomic alignment and full resolution of pain within 3 months, and full return to activity within 6 months. In conclusion, the establishment of management guidelines for pubic symphysis is recommended, including the use of non-surgical management early in the patient recovery process and in cases with diastasis greater than 2.5 cm. This treatment strategy may decrease morbidity, recovery time, and complications in affected patients.


Treatment of osteochondral lesions in the ankle with a particulated juvenile cartilage allograft: Four-year outcomes

May 2022

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42 Reads

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J. Chris Coetzee

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[...]

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PURPOSE: This investigation reports mid-term clinical outcomes after treating osteochondral lesions of the talus (OLTs) with a particulated juvenile cartilage allograft (PJCA). It was hypothesized that treatment of OLTs with PJCA would lead to significant improvement in pre to postoperative patient reported outcomes (PROMs). METHODS: The study was a multicenter longitudinal prospective case series. Lesions were treated with a PJCA. Primary outcomes were pain, function, and activity levels. Clinical outcomes for 24 prospective subjects over 4-years are presented. The overall PROMs were analyzed using repeated measures models to account for patient visits over time and to control for variability between patients. Repeated measures analyses was used to assess effect of OLT size, operative technique, and prior ankle operations. PROMs, stratified by OLT size, was further analyzed to assess improvement by OLT size. RESULTS: There was significant pre to postoperative improvement in the overall pain, Short-form 12 Health survey physical, Foot and Ankle Ability Measure activities of daily living, and Foot and Ankle Ability Measure sport (n = 22) scores at 12, 24, 36, and 48-months (p < 0.05). There were no significant pre to postoperative changes in the overall Short-form mental health scores (p > 0.05). Lesions less than 150mm2 predominantly achieved significant pre to postoperative improvement in scores over 48-months. Except for the sport scores at select visits, there were no differences in outcomes among postoperative visits(p > 0.05). When the variables of OLT sizes, operative technique, and prior ankle operation were compared, repeated measures did not reveal any differences between these variables in effect on PROMs. CONCLUSIONS: Four-year outcomes suggest that treatment with a PJCA led to improved function and pain levels without symptom worsening, and it is an effective operative intervention for symptomatic lesions irrespective of lesion size.


Bilateral Achilles Tendon Rupture: A Case Report and Review of the Literature

April 2022

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24 Reads

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3 Citations

Osteology

While Achilles tendon injuries are common amongst the general population, there are very few cases in which simultaneous bilateral injuries occur. Medial malleolar fractures at the time of Achilles tendon rupture have been cited in the literature and are commonly missed. The following case outlines the presentation, treatment, and outcome of a United States Army Soldier with simultaneous bilateral Achilles tendon ruptures in addition to a unilateral right medial malleolar fracture. This patient was able to completely return to duty within 1 year after being treated with ORIF of the medial malleolus, bilateral end-to-end repair of the AT, and accelerated rehabilitation beginning at 2 weeks on the left and 6 weeks on the right.


Prospective Results of the Modified Glide Path Technique for Improved Syndesmotic Reduction During Ankle Fracture Fixation

March 2022

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19 Reads

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9 Citations

Foot & Ankle International

Background Malreduction after syndesmotic stabilization occurs in as many as 52% of cases and has been shown to detrimentally affect clinical outcomes. We propose that the modified Glide Path technique reduces the occurrence of syndesmotic malreduction. Methods This study is a prospective series comparing 16 patients reduced with the modified Glide Path technique with a retrospectively reviewed series of 25 patients reduced with a traditional technique using fluoroscopy and a clamp. The modified Glide Path technique consists of manual reduction of the fibula and placement of a Kirschner wire through the fibula and tibia along the transmalleolar axis. The syndesmosis can then be reduced along the glide path created by the Kirschner wire to prevent posterior or anterior malreduction. Computed tomographic scans of the repaired and contralateral ankles were obtained postoperatively to assess reduction. Results We found a statistically significant decrease of syndesmotic malreductions using the modified Glide Path technique when compared with technique that did not use a glide path. In our study, 2 of 16 patients (12.5%) had syndesmotic malreductions using the modified Glide Path technique, compared with 11 of 25 patients (44%) with syndesmotic malreductions in the historical cohort. Conclusion The modified Glide Path technique is a simple method for ankle syndesmotic reduction. The technique has lower rates of malreduction compared with historical methods and may be useful for most operative syndesmotic injuries. Level of Evidence Level II, prospective cohort study.


Return to Run Rates Following Hallux Valgus Correction: A Retrospective Comparison of Metatarsal Shaft Osteotomies vs the Modified Lapidus Procedure

January 2022

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34 Reads

Foot & Ankle Orthopaedics

Category Bunion; Other Introduction/Purpose Hallux valgus affects 23 -36% in general populations. The purpose of this study was to evaluate return to run following either a modified Lapidus procedure or a metatarsal osteotomy. We hypothesized that there would be no difference in the ability to return to running. Methods A Retrospective review of a consecutive series of patients at a single institution with surgical correction was performed. 51 patients were identified. 35 were treated with a metatarsal shaft osteotomy and 16 with a modified Lapidus. Results No difference was found between the cohorts in terms of age, sex, or pre- operative hallux valgus angle (HVA). 27/35 (77%) with metatarsal shaft osteotomy were able to return to running versus 13/16 (81%) with modified Lapidus. There was no significant difference in the ability to return to running between cohorts (p=1.00). Conclusion Our study showed no statistical difference for the modified Lapidus versus metatarsal osteotomies relative to return to running.


Correlation of Stress Radiographs to Injuries Associated with Lateral Ankle Instability

January 2022

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15 Reads

Foot & Ankle Orthopaedics

Category Ankle; Sports Introduction/Purpose Stress radiographs have demonstrated superior efficacy in the evaluation of ankle instability. The purpose of this study is to determine if there is a degree of instability evidenced by stress radiographs that is associated with pathology concomitant with ankle ligamentous instability. Methods A retrospective review of 87 consecutive patients aged 18-74 who had stress radiographs performed at a single institution between 2014 and 2020 was performed. These manual radiographic stress views were then correlated with MRI and operative findings. Results A statistically significant association was determined for the mean and median stress radiographic values and the presence of peroneal pathology (p=0.008 for tendonitis and p= 0.020 for peroneal tendon tears). A significant inverse relationship was found between the presence of an osteochondral defect and increasing degrees of instability (p=0.043). Conclusion Stress radiographs may assist the surgeon in clinical decision making.


Outcomes Following Modified Broström for Chronic Lateral Ankle Instability With and Without Peroneal Tendon Exploration

November 2021

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8 Reads

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1 Citation

Foot & Ankle Specialist

Background It is not known how peroneal tendon exploration influences results after modified Broström for lateral ankle instability. We propose peroneal exploration at the time of modified Broström will have similar outcomes as no peroneal exploration. Methods A retrospective analysis was performed of patients undergoing modified Broström with and without peroneal exploration. Foot and Ankle Outcome scores and data regarding military retention were gathered and compared. Results Seventeen patients were identified in the modified Broström only cohort and 24 in the peroneal exploration cohort. Patients had mean follow-up of 5 years in both cohorts. The mean FAOS in the modified Broström only cohort was 68 and 72 in the cohort with peroneal exploration (P = .541). When each FAOS subcategory was analyzed, no difference was identified in any subcategory. Eight of 17 patients (47%) in the modified Broström only cohort remained active duty compared with 8 of 24 patients (33%) in the modified Broström with peroneal exploration cohort (P = .518). One patient medically discharged in the modified Broström only cohort versus 6 in peroneal exploration cohort (P = .109). Overall satisfaction with the procedure was 12 of 17 (71%) in the modified Broström only cohort and 19 of 24 (79%) in the peroneal exploration cohort (P = .529). Conclusions No significant difference was identified between patients undergoing modified Broström alone or modified Broström with peroneal exploration. There was no significant difference in return to duty, medical discharge or patient satisfaction. Levels of Evidence Level III: retrospective case-control study with prospectively collected data


Insertional Achilles Tendinopathy: Occupational Outcomes in the Military

October 2021

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5 Reads

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2 Citations

Foot & Ankle Specialist

A retrospective review of consecutive patients diagnosed with insertional Achilles tendinopathy (IAT) was performed. Outcomes included Visual Analog Scale (VAS) pain scores, return to run rates, and return to military duty rates. Our data analysis included 113 patients; 58 (55%) patients required surgery. Mean duration of follow-up was 42 months (range, 12-143). Mean age at the time of surgery was 37.2 years (range, 21-54). VAS scores significantly improved from 5.4 at the preoperative visit to 2.9 at 24 months. There was no significant improvement in VAS scores after the 3-month postoperative visit. Mean return to run time was 9 months (range, 4.5-16). At 1 year, 80% (46/58) of patients returned to military duty. Complications requiring return to the operating room were observed in 6 patients (9%). The high rate of return to duty and significant improvement in pain scores demonstrate that the surgical management of IAT is a viable treatment option for patients who could not otherwise remain on active duty. With that said, the complication rate of 27% is high. Patients and providers should consider the risks, benefits, and duration of therapy during their shared decision-making process. Level of Evidence: Level IV


Figure 1. The contour plots at (A-D) presurgery, 6 weeks, 6 months, and 1 year show the predicted IKDC score based on the PROMIS Physical Function and Pain Interference scores using a Gaussian generalized additive mixed model. The figure can be viewed as a Cartesian coordinate plot where the colors show the gradation of predicted IKDC score and the black lines show the predicted IKDC score for every 10 units. For example, a patient at 6 months who has a Physical Function score of -1 and Pain Interference score of 1 would have an approximate IKDC score of 50. IKDC, International Knee Documentation Committee; Preop, preoperative; PROMIS, Patient-Reported Outcomes Measurement Information System.
Figure 3. The contour plots show the predicted IKDC score based on the PROMIS Physical Function and Pain Interference scores using (A) Gaussian and (B) beta distribution generalized additive mixed models. In contrast to Figures 1 and 2, this figure's plots do not have an additional accounting for time from surgery. The figure can be viewed as a Cartesian coordinate plot where the colors show the gradation of the predicted IKDC score and the black lines show the predicted IKDC score for every decile. In both models, a Physical Function score of 0 and a Pain Interference score of 1 would have an approximate IKDC score of 60. IKDC, International Knee Documentation Committee; PROMIS, Patient-Reported Outcomes Measurement Information System.
A High-Sensitivity International Knee Documentation Committee Survey Index From the PROMIS System: The Next-Generation Patient-Reported Outcome for a Knee Injury Population

October 2021

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150 Reads

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4 Citations

The American Journal of Sports Medicine

Background: Patient-reported outcomes (PROs) measure progression and quality of care. While legacy PROs such as the International Knee Documentation Committee (IKDC) survey are well-validated, a lengthy PRO creates a time burden on patients, decreasing adherence. In recent years, PROs such as the Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function and Pain Interference surveys were developed as computer adaptive tests, reducing time to completion. Previous studies have examined correlation between legacy PROs and PROMIS; however, no studies have developed effective prediction models utilizing PROMIS to create an IKDC index. While the IKDC is the standard knee PRO, computer adaptive PROs offer numerous practical advantages. Purpose: To develop a nonlinear predictive model utilizing PROMIS Physical Function and Pain Interference to estimate IKDC survey scores and examine algorithm sensitivity and validity. Study design: Cohort study (diagnosis); Level of evidence, 3. Methods: The MOTION (Military Orthopaedics Tracking Injuries and Outcomes Network) database is a prospectively collected repository of PROs and intraoperative variables. Patients undergoing knee surgery completed the IKDC and PROMIS surveys at varying time points. Nonlinear multivariable predictive models using Gaussian and beta distributions were created to establish an IKDC index score, which was then validated using leave-one-out techniques and minimal clinically important difference analysis. Results: A total of 1011 patients completed the IKDC and PROMIS Physical Function and Pain Interference, providing 1618 complete observations. The algorithms for the Gaussian and beta distribution were validated to predict the IKDC (Pearson = 0.84-0.86; R2 = 0.71-0.74; root mean square error = 9.3-10.0). Conclusion: The publicly available predictive models can approximate the IKDC score. The results can be used to compare PROMIS Physical Function and Pain Interference against historical IKDC scores by creating an IKDC index score. Serial use of the IKDC index allows for a lower minimal clinically important difference than the conventional IKDC. PROMIS can be substituted to reduce patient burden, increase completion rates, and produce orthopaedic-specific survey analogs.


Citations (17)


... The overall results reinforced the evidence of the role of lesion type and wheel access in accelerating tendon healing, converging toward the hypothesis of the more targeted regenerative action of bilateral lesions with unrestricted running wheel access. In a study where an end-to-end repair was performed in a simultaneous bilateral AT rupture, the patient experienced a return to full activity after 1 year due to accelerated rehabilitation beginning at 2 weeks for the left limb and 6 weeks for the right, post-operation (50). ...

Reference:

Unraveling the link: locomotor activity exerts a dual role in predicting Achilles tendon healing and boosting regeneration in mice
Bilateral Achilles Tendon Rupture: A Case Report and Review of the Literature

Osteology

... При использовании методов статической фиксации наблюдали самую высокую частоту мальредукции сустава и поломки имплантата, повторных операций, а в группе динамической фиксации -самую высокую частоту неанатомичной фиксации синдесмоза. В группе комбинированных методов наблюдали самую низкую частоту осложнений, это связано с тем, что данная техника позволяет зафиксировать синдесмоз как в области передней тибиофибулярной связки, так и в области задней тибиофибулярной связки, снижает риск поломки имплантата, неанатомичного сращения, но повышает риск ятрогенного перелома [38][39][40][41]. ...

Prospective Results of the Modified Glide Path Technique for Improved Syndesmotic Reduction During Ankle Fracture Fixation
  • Citing Article
  • March 2022

Foot & Ankle International

... 12,13 A recent retrospective study on active duty personnel with insertional AT who failed conservative treatment showed that surgical management could be a successful treatment option for returning to military duty. 14 For AT, HVIGIs, commonly described as hydrodissection or Brisement procedure, feature fluid injected under ultrasound guidance into the peritendinous tissue deep to the Achilles tendon to mechanically separate the paratenon from the underlying Kager's fat pad. There may also be a beneficial effect of scar tissue and neoneurovascular breakdown. ...

Insertional Achilles Tendinopathy: Occupational Outcomes in the Military
  • Citing Article
  • October 2021

Foot & Ankle Specialist

... Six orthopaedic surgeons and one radiologist reviewed the images. The study showed that the likelihood that further imaging is necessary to guide treatment decisions was higher by around twice for the mini-C-arm imaging group [12]. This was not the experience within this study where outcomes for injuries such as wrist fractures followed historical norms with 11 patients eventually having surgical intervention out of 53 (20%). ...

Quality of Mini C-Arm Imaging in Post-Reduction Evaluation of Distal Radius Fractures

Osteology

... The findings of this study corroborate previous work from MOTION as it relates to the shoulder. 24,25 This study demonstrates the properties of PROMIS surveys appear widely stable over time and that the PROMIS system measures the same theoretical constructs in two different orthopedic populations, demonstrating its viability for clinical use. ...

Generating the American Shoulder and Elbow Surgeons Score Using Multivariable Predictive Models and Computer Adaptive Testing to Reduce Survey Burden

The American Journal of Sports Medicine

... Bacterial identification rarely led to a change in antibiotic molecule (< 1 in 10 cases) [33]. Furthermore not having bacterial identification was not associated with a higher rate of failure [14]. ...

Empirical Treatment of Uncomplicated Septic Olecranon Bursitis Without Aspiration

The Journal Of Hand Surgery

... This has the goal to allow for sufficient loading for graft incorporation and cartilage restoration [3]. There is increasing attention to postoperative rehabilitation protocols, as early weight bearing may improve clinical outcomes in ankle surgery, including the treatment of osteochondral lesions of the talus [7,40]. However, weight bearing too early might result in an inadequate healing process of the osteotomy and, for example, lead to malunion of the osteotomy or degenerative changes to the graft [20,22]. ...

Early vs Delayed Weightbearing After Microfracture of Osteochondral Lesions of the Talus: A Prospective Randomized Trial

Foot & Ankle Orthopaedics

... Early range of motion may positively affect the restoration of the surgically treated cartilage [25]. Qualitative factors considered important in the starting moment of range of motion were the healing of the incision and the healing of the osteotomy site [26][27][28]. Although the exact timing of starting range of motion needs to be determined for each procedure individually, using an appropriate type of casting or walker will facilitate a range of motion exercises while the patient is still in the immobilisation phase. ...

Osteochondral Allograft Transplantation Surgery for Osteochondral Lesions of the Talus in Athletes
  • Citing Article
  • April 2019

The Journal of Foot & Ankle Surgery

... 21 More recently, transplantation with a fresh particulated AC allograft has been developed and involves the use of viable juvenile chondrocytes (\13-year-old donors) to repair AC defects in situ (eg, DeNovo NT Natural Tissue Graft [Zimmer Biomet]). 2,6,8,11,28,29,34,40 Between 2003 and 2013, more than 8700 patients were successfully treated using particulated AC grafts, including in the knee and the ankle, with no reports of graft rejection. 12,23,24,29,34 In a 2-year follow-up study, histological analysis of postoperative biopsy specimens from 8 patients showed both hyaline cartilage and fibrocartilage regeneration within the original defect site. ...

Comparative Outcomes for the Treatment of Articular Cartilage Lesions in the Ankle With a DeNovo NT Natural Tissue Graft: Open Versus Arthroscopic Treatment

Orthopaedic Journal of Sports Medicine

... Multiple studies used different tests to determine rehabilitation from injury. These tests range include: single leg landing [8], asymmetry [9], risk factors [10], Functional Movement Screen (FMS) [11], the American Foot and Ankle Score Outcome (AOFAS), Single Assessment Numeric Evaluation (SANE) [12], and procedure and delaying outcomes [13][14][15]. 2022 ...

Return to Duty Following Open Reduction and Internal Fixation of Unstable Ankle Fractures in the Active Duty Population

Military Medicine