P K Das's research while affiliated with Indian Council of Medical Research and other places

... The collected data clearly indicate that the risk of filarial infection in Indonesia does not remain constant throughout the country, but rather is province-dependent. This aligns with findings from previous studies in India [20]. Factors such as the environment, landscape and climate, e.g., temperature, annual rainfall, altitude and humidity, had a significant impact to the transmission of filariasis [21]. ...

... It may be noted that Kushta Qalai drug is orally administered in human subjects at a dose level of 125mg/kg body weight per day for a period of 30 days. (Das, et al., 2002;Fauci, et al., 2008;Park, 2009). The disease is endemic in many countries in Africa, South Asia, the Pacific Islands and Americas. ...

... Previous studies have addressed the topic of lost productivity years, number of life-lost years and overall lost production using only retrospective approaches for tsunami (Krishnamoorthy et al. 2005) and earthquakes (Wang et al. 2008 Noy (2014; and applied at global level based also in disaster databases. ...

... 62 For rapid killing of microlariae by DEC (1), inducible nitric oxide was found to be an essential factor. 63 However, combination therapy of DEC (1) with albendazole (4) revealed effective killing of W. bancroi microlariae, but this treatment was followed by the development of hydroceles and worsening of the pre-existing hydroceles. 64 In light of its pharmacokinetic studies, DEC (1) is almost completely absorbed aer oral administration and is widely distributed in non-fatty tissues. ...

... One thousand two hundred and twenty individuals (Abaji: 687; Bwari: 533) were interviewed in the household survey while eighteen (18) key informant interviews (KIIs) and sixteen (16) focus group discussions (FGDs) were used to gain insight on community engagement, participation, utilization of MDA and perception of the NTD programmes. ...

... Literature reveals that the first dengue outbreak was reported in Puducherry in the year 2003. [12] Since then, outbreaks are occurring regularly in Puducherry with the number of cases increasing every year. In 2017, 4568 dengue cases were reported of which seven proved fatal. ...

... It is documented that DEC acts through the enzymes of the arachidonic acid metabolic pathway and clears the mf through the innate immune-mediated mechanism (Maizels and Denham 1992;Mackenzie and Kron 1985). The study on DEC action revealed the involvement of cyclooxygenase pathway enzymes, viz., prostaglandin E2 and prostaglandin I2, and their inhibition as well as inducible nitric oxide synthase (iNos) in platelets for the clearance of microfilariae (Chen and Mehta 1996;McGarry et al. 2005;Sankari et al. 2013). Wider individual variation observed in the study (Fig. 5(a) and (b)) may be attributed to single nucleotide polymorphisms (SNPs) in the genes coding for enzymes of the arachidonic acid pathway in humans. ...

... Wolbachia plays an important role in the biology of the host and in the immunopathology of filariasis (Brattig et al. 2000;Taylor 2002;Keiser et al. 2002). The phylogenetic analysis of Wolbachia endosymbiont of the lymphatic filarial parasite showed that their phylogeny agrees with the phylogenetic structure of their host-parasite such as B. malayi, W. bancrofti, O. volvulus, etc., which indicates that they have evolutionary significance on parasite-endosymbiont association (Taylor et al. 1999;Casiraghi et al. 2004Casiraghi et al. , 2005Foster et al. 2005;Ferri et al. 2011;Sharma et al. 2013). Many genes of Wolbachia of human lymphatic filarial parasite have been characterized to focus on Wolbachia-based control strategies of filariasis (Brattig et al. 2000;Hoerauf et al. 2000;Taylor 2000;Dhamodharan et al. 2011;Sharma et al. 2013;Slatko et al. 2014;Shahab et al. 2014). ...

... Filarial nematodes are parasites transmitted by mosquitoes such as Aedes and Culex 22 . Lymphatic lariasis, a human infection of public health importance that is caused by Wuchereria bancrofti and Brugia malayi, is a neglected tropical disease similar to dengue fever 23 . ...

... Published Online: Dec 31, 2023 tion of shortages, providing breeding sites for mosquitoes. The most common clinical symptoms reported were fever (99.1% to 100%), myalgia (65-70%), headache (55.5%), nausea (39.1 %), skin rash (53.6%), mucocutaneous hemorrhagic manifestations (58.2%), and ocular pain (20%) in some other studies, similar to the finding of the present study (25)(26)(27)(28). However, studies from other parts of India had clinical presentations that were different (19,29). ...