P Aubert's scientific contributions
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Publications (34)
"Sensitive" thyrotropin (TSH), thyroglobulin (TG) and even thyrotropin binding inhibiting immunoglobulins (TBII) assays are now widely available. The objective of the present study was to determine the most accurate of these three parameters to predict the relapse of Graves' disease during the year following treatment discontinuation and to evaluat...
The serum concentrations of the different forms of circulating testosterone, total testosterone, free testosterone and non-sex-hormone binding globulin bound testosterone (albumin bound + free fractions) which is considered as the bioavailable hormone, were measured in 15 hyperthyroid women before and after anti-thyroid drug therapy and in 15 age-m...
Medullary thyroid carcinoma is a rare and sometimes hereditary disease. The tumour can be diagnosed and followed up by measuring the amounts of calcitonin it secretes. The prognosis of this cancer largely depends on an early diagnosis and treatment. From the clinical and laboratory (calcitonin assays) data recorded in our department, we have endeav...
We compared the diagnostic value of information given by total testosterone (I), free testosterone (II), the free androgen index (III), and testosterone not bound by sex-hormone-binding globulin (SHBG) (IV) as measured by a new differential ammonium sulfate precipitation technique, each step of which is conducted at 37 degrees C. SHBG and albuminem...
More than 500 sera were assayed for TBII under routine conditions using "Trak" assay in order to evaluate the sensitivity, specificity and prognostic interest of this determination in hyperthyroidism. The sensitivity for the diagnosis of Graves' disease was 83.5%, better in ophthalmopathic patients (93%) than in non ophthalmopathic patients (75%)....
In addition to motor and sensory nerve conduction, monosynaptic triceps surae reflex, amplitude of median nerve voltage and response of extensor digitorum brevis and soleus muscles were investigated in 29 diabetic patients. These parameters were altered earlier than motor and sensory nerve conduction, which considerably increased the incidence of s...
Out of 50 patients with anorexia nervosa observed at Saint-Antoine's Hospital, Paris, between 1969 and 1979, 34 were examined in 1980-1981 or had answered a questionnaire. Intermediate (2/3 years) and long term (more than 4 years) outcome were estimated for 28 and 29 patients respectively, based upon 5 items groups, each of them assessed 0, 0,5 or...
Out of 50 patients with anorexia nervosa observed at Saint-Antoine's Hospital, Paris, between 1969 and 1979, 34 were examined in 1980-1981 or had answered a questionnaire. Intermediate (2/3 years) and long term (more than 4 years) outcomes were estimated for 28 and 29 patients, respectively, based upon 5 items groups, each of them assessed 0, 0.5 o...
Platelet function (aggregation with ADP), plasma and platelet fatty acids, lecithin cholesterol acyl transferase (LCAT) activity and free HDL cholesterol (HDLC) were studied in 15 hyperthyroid and 10 primary hypothyroid patients before treatment and after normal thyroid function was restored by drug therapy to determine the role of thyroid hormones...
The result of a systematic research of autonomic neuropathy in 184 diabetic patients, was positive in 51 patients (28%). In 6 cases the acuteness of that diabetic complication, obliged application of a specific symptomatic treatment. 9 Alpha-Fluorocortisone has permitted control of the orthostatic faintness (4 cases). Metoclopramide was effective o...
The possibility to use the liposomes as drug vehicles has been largely investigated in recent years. Most of the studies have been carried out in animals and are related to disease involving predominantly the reticulohistiocytic system. Attempts to use these liposomes orally (induced diabetes) or locally (induced arthritis) are also reported. Furth...
In a 14-year-old boy, neurological signs (fall in visual acuity, signs of raised intracranial pressure) led to a diagnosis of stenosis of the aqueduct of Sylvius. Cure was obtained by insertion of a ventriculo-cardiac bypass (Holter's valve). Endocrine signs (delayed growth, excessweight, loss of circadian variations in cortisol levels) regressed i...
A 56 yr old male, suffering from rheumatoid arthritis since 1958, developed rheumatoid pleuritis, not influenced by corticosteroid therapy. Some months later he developed constrictive pericarditis, which had to be operated. The literature is reviewed.
Isolated adrenocorticotropin deficiencies are rare. Two cases are reported, one, with hypoglycaemia, the other with weakness and hypotension, with a review of the published cases during the past twenty years. The adrenal defect impairs severely the glucocorticoid secretion while aldosteron is normal. Tetracosactid stimulates adrenal secretion. ACTH...
Citations
... The goal treatment for preventing CVD complications in elderly with DM must be individualized and should be attention on the potential for greater harm [7] due to they have more physical limited, cognitive functioning decline, and physiological changes that would affect self-management ability to prevent CVD complications [8] . Preventing CVD complications in elderly with DM can be carried out by performing the preventing cardiovascular complications behaviors (PCCB) which consist of DM diet and heart healthy diet, physical exercise, taking medications regularly, and smoking cessation [3] . ...
... Anorexia Nervosa (AN) poses serious psychosocial and health problems for women (see Ng, Cheung, & Chou, 2013a, 2013b including an increased risk of mortality (Hoek & van Hoeken, 2003a, 2003bMustelin et al., 2015). It has been estimated that between 3% to 10% of females between 15 and 29-years of age show AN (Polivy & Herman, 2002; also see Hoek & van Hoeken, 2003a, 2003b. ...
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... This oddity of the hypothalamic-pituitary-gonadal axis correlates with the concentrations of serum T4 and regain the normal correction of the hyperthyroidism by treatment with thyroid hormone inhibitors as the use of PTU in our study. The concentration of sex hormone-binding globulin (SHBG) in serum or plasma is increased (26) that is associated with the rise in total testosterone level (27). The changes in the concentration of total testosterone resulted in a studied blood outcome rate for testosterone in patients with hyperthyroidism that is not significantly diverse from normal individuals (28). ...
... Additionally, GD patients with the PD-L1 SNP (rs822339) showed longer treatment duration compared to GD patients without the PD-L1 SNP. TBII had high sensitivity and specificity for the diagnosis of GD and was a possible predictor of relapse of GD [23][24][25]. In our study, higher TBII titer in GD patients with the PD-L1 SNP might be related to elevated disease activity through the dysregulation of immune activities. ...
... Total testosterone was measured by RIA (Beckman Coulter -Immunotech, Marseille, France). Bioavailable testosterone was measured after ammonium sulfate precipitation as previously described (34,35). Follicle-stimulating hormone (FSH), luteinizing hormone (LH), inhibin B, estradiol, glucose, triglycerides, total and HDL cholesterol, insulin, and C-reactive protein (CRP) were routinely measured on Cobas analyzer (Roche Diagnostics). ...
