Olivier Chartrand-Oberoi's research while affiliated with Université du Québec à Montréal and other places

Objective: To assess the incidence of systemic side effects and complications of ultrasound-guided and fluoroscopy-guided glucocorticoid injections (GCIs) and to identify associated risk factors. Design: This retrospective cohort study compared participants who received a GCI at the outpatient clinic and participants who had an appointment but did not receive a GCI. Participants were called to verify if they had experienced any of the predetermined systemic side effects and complications. Multiple binary logistic regression was used to identify systemic side effect and complication risk factors. Results: There were 1010 participants in the GCI group and 328 in the non-GCI group. There was no statistically significant difference in the occurrence of systemic infection and decompensated heart failure between the two groups. More participants in the GCI group developed abnormal uterine bleeding and erectile dysfunction but the differences did not reach statistical significance. Female participants were 1.9 times more likely to develop systemic side effects (p < 0.001). Younger age (p < 0.001), diabetes (p = 0.012), and higher GCI doses (p = 0.024) were also associated with an increased risk of developing systemic side effects. Conclusion: Identified risk factors for developing GCI systemic side effects were younger age, female sex, diabetes, tobacco use, and high GCI doses.