Noriko Marutani's research while affiliated with Osaka University and other places
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Publications (5)
This retrospective cohort study investigates the association between the incidence of sleep problems and changes in digital media use among university students during the COVID-19 pandemic. It used data from annual health check-ups performed at a Japanese university in 2019 and 2020. Students undergoing these check-ups were identified to respond to...
Background:
Patients with diabetes are at a higher risk for cognitive decline. Thus, biomarkers that can provide early and simple detection of cognitive decline are required. Neurofilament light chain (NfL) is a cytoskeletal protein that constitutes neural axons. Plasma NfL levels are elevated when neurodegeneration occurs. Here, we investigated w...
Objectives
To investigate the relationship between differences in weekday-to-weekend sleep habits and stress responses in a working population.
Methods
This cross-sectional study used data from university workers on sleep habits, differences in sleep duration between weekdays and weekends, and each midpoint of the sleep phase on weekdays and weeke...
Background
It has recently been reported that pathological molecules of Alzheimer’s disease (AD), such as tau, are transmitted through extracellular vesicles (EVs). We hypothesized that AD‐related proteins are detectable in neuron‐derived EVs (NDE) present in peripheral blood, since the pathological proteins will be protected by the lipid bilayer o...
Neurofilament light chain (NfL) is a novel biomarker of neurodegenerative diseases. It is detectable in the peripheral blood, allowing low-invasive assessment of early signs of neurodegeneration. The level of NfL gradually increases with age; however, what other factors affect it remains unclear. The present study examined the association between b...
Citations
... Participants eligible for this study were university students aged ≥ 18 years old who were non-smokers upon their admission to Osaka University between 2007 and 2015 [14][15][16]. To include non-smokers at admission, smoking status of each student was determined by the question of general questionnaire at admission, "Do you smoke?" with four possible responses of "I do not smoke," "I quit smoking," "I would like to quit smoking," and "I smoke." ...
... So, plasma NfL could be considered a good biomarker of neurodegeneration [46,47]. In fact, NfL increase could be caused by some neurological pathologies [48][49][50][51] not being AD-specific. In relation to CSF t-Tau levels, considered important neurodegeneration biomarkers, no statistically significant correlations were observed in any participant group. ...
... Under anomalous environmental rhythms such as a 16-h light/8-h dark cycle 13 and delayed 14 or advanced 15,16 phase shifts, rodents respond by altering their circadian cycles within a certain range but may also exhibit some physiological malfunctions 17,18 . Indeed, discrepancies between environmental and internal rhythms cause stress and often lead to social and psychological disorders 6, 19,20 . Studying the biological responses to circadian time distortion is of particular importance for elucidating the effects of long work hours (time shifts) and long-distance travel (time gaps). ...
... The contrasting findings might be because the increment in systolic and diastolic blood pressure might eventually have opposite effects on the risk for ALS; namely, systolic blood pressure might be a risk factor, whereas diastolic blood pressure might be a protective factor, for ALS [46]. In a sample of healthy individuals over 60 years, kidney function was found to negatively correlate with neurofilament light chain (NfL) [47], partially explaining the link between hypertension and a poorer prognosis after ALS diagnosis. A higher stage of chronic kidney disease and a lower concentration of cystatin C-based-eGFR have also been associated with ALS risk [48], indicating a potential explanatory mechanism for the link between hypertension and ALS. ...
