Ning Li's research while affiliated with North China University of Technology and other places
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Publications (3)
The current study examined whether the steroid hormone, 17β-estradiol (E2) can exert long-lasting beneficial effects upon axonal health, synaptic plasticity, dementia-related amyloid-beta (Aβ) protein expression, and hippocampal-dependent cognitive function in an animal model of chronic cerebral hypoperfusion and vascular dementia (VaD). Chronic ce...
Unlabelled:
The current study examined efficacy of a small Tat (trans-activator of transcription)-conjugated peptide activator of the Nrf2 (nuclear factor-E2-related factor-2) antioxidant/cell-defense pathway as a potential injury-specific, novel neuroprotectant against global cerebral ischemia (GCI). A competitive peptide, DEETGE-CAL-Tat, was des...
Citations
... Sex differences have been reported in cerebral blood flow across the lifespan with females generally displaying greater CBF and sex steroid hormones are found throughout the vasculature (Robison et al., 2019). There have been relatively few studies that directly compare hypoperfusion outcomes across the sexes, however treatment with the sex steroid estradiol and progesterone both alleviate the deleterious consequences of hypoperfusion in male rodents (Aggarwal et al., 2008;Zhu et al., 2017). Additionally, where there were clear detrimental effects on spatial learning and memory of both BCAS and TBI among males, females exhibited only a BCAS effect. ...
... Under basal conditions, Nrf2 is sequestered in the cytoplasm by the repressor protein Keap1 [23]. However, under cellular stress (i.e., oxidative stress), it translocates to the nucleus, where it utilizes its transcriptional activity to induce the production of many defense proteins, including heme oxygenase 1 (HO-1) and NAD(P)H: quinone oxidoreductase-1 (NQO1) [22,24,25]. Kraft et al., reported that Nrf2 knockout mice were more sensitive to kainate toxicity, as evidenced by elevated seizure severity, duration, hippocampal neuronal damage, and mortality [26]. ...
