Nga Yi Tsang's research while affiliated with Hong Kong Baptist University and other places
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Publications (6)
One of the structural uniqueness of arylnaphthalene lignans (ANLs) is their potential atropoisomerism, which may result in bioactivity discrepancy. However, the stable ANL atropisomers rarely exist in nature. In the course of our phytochemical study of Justicia procumbens, we isolated nine ANL glycosides (1–9) with four of them (1–4) being identifi...
Three isopimarane diterpenes [fladins B (1), C (2), and D (3)] were isolated from the twigs and leaves of Chinese folk medicine, Isodon flavidus. The chemical structures were determined by the analysis of the comprehensive spectroscopic data, and the absolute configuration was confirmed by X-ray crystallographic analysis. The structures of 1–3 were...
Ebola virus disease (EVD), a disease caused by infection with Ebola virus (EBOV), is characterized by hemorrhagic fever and a high case fatality rate. With limited options for the treatment of EVD, anti-Ebola viral therapeutics need to be urgently developed. In this study, over 500 extracts of medicinal plants collected in the Lingnan region were t...
Two new tigliane diterpenes, named eupneonoids A (1) and B (2), together with four known analogues (3-6) were isolated from the whole plant of Euphorbia neorubella Bruyns. Their structures were deduced based on the detailed spectroscopic analysis. All the isolates displayed cytotoxic effects against A549 human tumor cell lines with IC50 values rang...
Background:
Cancer is a leading cause of mortality in the world and metastasis is to blame. A number of naphthoquinones (NQs) have shown ability to reduce cancer stemness and metastatic potential. Furano-naphthoquinones (FNQs), which is a class of NQ characterized by the incorporation of an additional furan ring, have demonstrated improved anti-ca...
Background: Avian influenza, commonly known as bird flu, is caused by viruses adapted to birds; however, some of the avian viruses are highly pathogenic to the human population. Though vaccines have been developed for the prevention of avian influenza, the emerging resistant strains greatly limit the effectiveness of these mainstay prophylactic dru...
Citations
... Lignans from Justicia spp. also demonstrated antiviral activity against HIV-1 [61][62][63]. Arylnaphthalene lignans from J. procumbens, justatropmers A-H, showed potent anti-HIV-1 activity [63]. The anti-HIV-1 activity was also reported for 70%-fractionated ethanolic extract of J. gendarussa on HIV-infected MOLT-4 cells using syncytia formation assay and HIV p24 antigen assay [64]. ...
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... Li et al, (2022) reported three new 3,4-seco pimarane diterpene compounds from the leaves and twigs of Isodon flavidus (Hand.-Mazz.) H. Hara (Lamiaceae) [84]. The structure shows a δ-lactone ring and the carbon-carbon double bond of the isopropyl group seems to be related to antiviral activity. ...
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... Dimeric PAC and several flavan-3-ol monomers within this extract were found to be potent EBOV entry inhibitors at low micromolar concentrations. By docking analysis and microscale thermophoresis technology, the authors determined that these compounds exhibited virucidal potency by interacting with EBOV glycoprotein, and the most efficient antiviral compound was the PAC-B2 [259]. ...
... Tigliane and ingenane diterpenoids from E. tirucalli [17]. E. neorubella has tigliane diterpenoids with cytotoxic activity [18]. Abietane and para-lianone type diterpenoid from E. peplus [19]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/11431281247855133-1716951312018_Q64/Hongjie-Zhang-26.jpg)
... [31][32][33] Furano-naphthoquinone, a class of naphthoquinone characterized by a fused furan ring, have shown promising biological potency. [34][35][36][37] For example, the synthetic dihydrofurano-naphthoquinone compounds (1) have exhibited potential as anti-trypanosoma cruzi, 38 anticandidal, 39 and antitumoragents ( Figure 1). 40,41 Other example, the synthetic furanonaphthoquinone compounds (2) displayed high activity (IC 50 < 2.9 ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/578944560185344-1515042547523_Q64/Siu-Wai-Tsang.jpg)
... AIV that is only circulating in avian species seldom infects people, whereas AIV that is only circulating in humans rarely transfers to avian species [6]. H5N1 AIV, a highly virulent AIV that arose in Hong Kong in 1996-97, had caused outbreaks in poultry or wild birds in over sixty countries and 317 human cases, including 191 fatalities, by June 2007 [7]. ...
