November 2023
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8 Reads
International Immunopharmacology
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November 2023
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8 Reads
International Immunopharmacology
July 2023
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79 Reads
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5 Citations
Biochemical Genetics
A new era of medical technology in cancer treatment is a directly specific modification of gene expression in tumor cells by nucleic acid delivery. Currently, the main challenge to achieving this goal is to find a non-toxic, safe, and effective strategy for gene transfer to cancer cells. Synthetic composites based on cationic polymers have historically been favored in bioengineering due to their ability to mimic bimolecular structures. Among them, polyethylenimines (PEIs) with superior properties such as a wide range of molecular weight and a flexible structure may propel the development of functional combinations in the biomedical and biomaterial fields. Here, in this review, we will focus on the recent progressions in the formulation optimization of PEI-based polyplex in gene delivery to treat cancer. Also, the effect of PEI's intrinsic characteristics such as structure, molecular weight, and positive charges which influence the gene delivery efficiency will be discussed.
... Generally, in this article, we have reviewed recent research on nanomaterials' capacity to suppress the process of EMT in cancerous cells, which may be used to control numerous essential aspects for instance invasive/migratory capacities, the phenotype of stem cells, and growth of tumor [152,153]. Pancreatic cancer 1) Factors promoting growth, such as transforming growth factor (TGF), epidermal growth factor, and hepatocyte growth factor, along with the Wnt/betacatenin and Notch pathways, have the potential to activate pathways that stimulate EMT. 2) Epigenetic changes can lead to EMTinduced chemo-resistance by reducing the expression of hENT1 nucleoside transporter needed for gemcitabine uptake [94,134] Gastric cancer 1) EMT expression in parental cells is evidence of increased resistance to paclitaxel. ...
July 2023
Biochemical Genetics