Neha Gupta's scientific contributions

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Publications (3)


Fig. 1: CT scanhead/PNS showing frontal sinusitis with necrotic frontal bone with underlying pachymeningitis
Fig. 2: Repeat MRIof the brain showing no increase in necrotic bone, but a localised collection
COVID-19 associated mucormycosis with frontal bone osteomyelitis
  • Article
  • Full-text available

July 2022

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65 Reads

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1 Citation

IP Indian Journal of Immunology and Respiratory Medicine

Neha Gupta

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Rajeev Gupta

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Rajiv Goel

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[...]

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V P Singh

During the coronavirus disease 2019 (COVID-19) pandemic, increasing cases of COVID-19 associated mucormycosis (CAM) have been reported. This may be attributed directly to the COVID-19 infection or the associated unrecognised uncontrolled hyperglycaemia compounded by the use of COVID-19 treatment strategies such as steroids and IL-6 inhibitors. As mucormycosis is one of the most rapidly progressing fungal infection, an early diagnosis and early appropriate management are of prime importance in reducing mortality. Rhino-orbital-cerebral and pulmonary mucormycosis have been the most common presentations of CAM. Osteomyelitis in mucormycosis is very rare, although a few cases of maxillary bone involvement have been reported with CAM. We report a very rare and challenging case of extensive frontal bone osteomyelitis in a patient with CAM with frontal sinusitis and without orbital or maxillary bone involvement.

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Citations (1)


... 84 In addition, 5FC in combination with amphotericin B has been used to treat Aspergillus endocarditis and complicated Aspergillus urinary tract infections. 85,86 However, there has been controversy regarding the effectiveness of 5FC against Aspergillus species because the activity of 5FC on Aspergillus species in vitro is dependent on the pH. 87 Studies observed high MIC values of 5FC against A. fumigatus at pH 7 compared with low MIC values obtained when investigated at pH 5. 83 A small randomized study of 5FC combination therapy with or without amphotericin B in hematology patients with invasive aspergillosis showed no benefit or even hint of benefit. ...

Reference:

Flucytosine and its clinical usage
Successfully Treated Post-urosurgical Urinary tract Aspergillosis

Journal of Case Reports