Neeru Adlakha's research while affiliated with C.K. Pithawalla College Of Engineering & Technology and other places

Publications (89)

Article
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The development of computational methods for reliably identifying epitopes is extremely desirable, as experimental methods are time and expense prohibitive. However, the presence of inherent uncertainty in the data as well as uncertainty in the interactions between the properties of epitopes is a significant barrier, leading to issues with accuracy...
Article
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Calcium dynamics is not only responsible for maintaining the framework and functions of the cell but also plays a role in the dynamics of other biochemical systems in the cell. Phospholipase C-[Formula: see text] l ([Formula: see text]) has a crucial role in the function of fibroblast cells. Experiments have shown that [Formula: see text] and [Form...
Article
The individual study of [Formula: see text] and [Formula: see text] dynamics respectively in a [Formula: see text]-cell has yielded limited information about the cell functions. But the systems biology approaches for such studies have received very little attention by the research workers in the past. In the present work, a system-dynamics model fo...
Article
[Formula: see text] signals have a crucial role in the immune system for cell functions such as proliferation, differentiation, apoptosis and gene transcription as well as the activation of Nuclear factor of activated T Cell (NFAT) which modulates the immune response of the cells. In this study, a fractional order spatiotemporal calcium dynamics mo...
Article
The cooperative system of calcium (Ca[Formula: see text]) and inositol 1,4,5-trisphosphate (IP 3 ) plays a crucial role in maintaining structure and functions of T lymphocyte cells including the production of nuclear factor of activated T cells (NFAT) as an immunological response. NFAT regulates several mechanisms and dysregulation in this process...
Article
Calcium ([Formula: see text]), inositol trisphosphate ([Formula: see text]), and nitric oxide (NO) signaling are essential to maintain the structural integrity and physiological activity of fibroblast cells. The accumulation of excess quantity of NO for longer periods can lead to a variety of fibrotic disorders, including heart disease, penile fibr...
Article
T lymphocytes have a primary role in both health and disease. Extracellular and intracellular signals determine whether a T-cell activates different cells, divides, or begins apoptosis. The reaction–diffusion process of [Formula: see text] ions is critical for the initiation, sustenance, and termination of the immunological function of T cell. A no...
Chapter
Investigators in the past proposed thermal model of breast in many—idealized conditions without considering the developed the female breast at different stages. In fact the size and the Microstructure of a female breast varies with the different stages of its development. Thus the biophysical processes affecting the heat transport also change with...
Article
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The human body regulates the body core temperature at a uniform temperature to maintain the structure and function of various physical and physiological processes. The physical exertion causes thermal stress which can disturb these mechanisms of thermoregulation under various environmental conditions and can lead to impairment of physiological func...
Article
The role of astrocytes in physiological processes is always a matter of interest for biologists, mathematicians and computer scientists. Similar to neurons, astrocytes propagate Ca 2+ over long distances in response to stimulation and release gliotransmitters in a Ca 2+ dependent manner to modulate various important brain functions. There are vario...
Article
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HIV is a human immunodeficiency virus causes AIDS (acquired immunodeficiency syndrome) which leads to life-threatening opportunistic infections. HIV-1 has three groups M, N, O known worldwide. Group M is widely distributed as it has nine subtypes and circulating recombinant forms are also developed due to rapid recombination and mutation. They play...
Conference Paper
Calcium is ubiquitous second messenger which controls vital functions of almost all eukaryotic cells. Hepatocyte cell is parenchymal cell of liver. The regulation of calcium concentration in a hepatocyte cell is still not well understood. A model is proposed in this paper to study the distribution of calcium concentration in a hepatocyte cell in pr...
Article
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BACKGROUND Mathematical modeling of biothermal processes is widely used to enhance the quantitative understanding of thermoregulation system of human body organs. This quantitative knowledge of thermal information of various human body organs can be used for developing clinical applications. In the past, investigators have studied thermal distribut...
Article
Many cells use oscillations in calcium concentration to transmit messages. These oscillations largely depend on the influx of calcium into cytosol from endoplasmic reticulum (ER) and plasma membrane (PM) through various channels and pumps. To analyze the influence of transfer of calcium between different cellular compartments, we develop a mathemat...
Article
The physical exercise imposes challenges on the human thermoregulatory system, as heat exchange between the body and environment is substantially impaired, which can lead to decrease in performance and increased risk of heat illness. In view of above a three-dimensional finite element model is proposed to study the effect of different intensities o...
Article
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Background: Mathematical modelling of bio thermal processes is widely used to enhance the quantitative understanding of thermoregulation system of human body organs. This quantitative knowledge of thermal information of various human body organs can be used for developing clinical applications. In the past the investigators have studied thermal dis...
Article
Human beings are equipped with thermo sensitivity, thermoregulation and thermo protection for maintaining the structure and function of their body organs. The thermoregulatory responses and disturbances caused by physical activity in thermo biomechanics of human body organs are not well understood. The mechanism of thermoregulation exhibits a beaut...
Article
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Phylogenies are the commonly used tools for the prediction of ancestry of present day organisms from the past decades. Several methods have been developed to construct phylogenetic trees that predict the history of species by direct linkage of edges. Very few studies have been developed for the phylogenetic networks which is the generalization of t...
Article
Sodium calcium exchanger (NCX) plays an effective role in signal transduction in most of the nerve cells like neuron, astrocytes etc. Sodium ion affects the cytosolic calcium concentration level in Astrocytes via various channels. Which affects the movement of the nerve impulse from one cell to other cell. In this paper two dimensional model is dev...
Article
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Nocardia farcinica causes human infections either by pulmonary inhalation or inoculation via wounds and causes nocardiosis, brain abscesses and secondary infection in immune-compromised patients. N. farcinica infection is mostly reported in Asia, Europe and North America with a mortality rate of 10-31%. Antibiotic treatment available for N. farcini...
Article
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The main functional cell of the liver is hepatocyte. The frequently working of liver depends on the particular level of cytosolic Ca2+ in hepatocyte. Cytosolic calcium is a second messenger which responsible for reproduction. Calcium controls many biological processes like movement of cell, secretion, muscular contraction, cell differentiation and...
Article
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Prediction of epitope has great importance in the development of vaccine, drug and peptide libraries and immunologic research. There are very few methods for the prediction of patches containing conformational epitopes, and ninety percent of the epitopes are of conformational type. In this paper, an attempt has been made to propose soft support vec...
Article
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The multi physical process involving calcium ions regulate expansion and contraction of cardiac myocytes. This mechanism of expansion and contraction of cardiac myocytes is responsible for contraction and expansion of heart for pumping of blood into arteries and receiving blood into heart from vein. Thus calcium dynamics in cardiac myocytes is resp...
Article
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The calcium signaling plays a crucial role in expansion and contraction of cardiac myocytes. This calcium signaling is achieved by calcium diffusion, buffering mechanisms and influx in cardiac myocytes. The various calcium distribution patterns required for achieving calcium signaling in myocytes are still not well understood. In this paper an atte...
Article
The present study deals with the temperature variation in dermal layers of irregular tapered shaped human limb involving metastasis of tumors. Two uniformly perfused tumors are assumed to be present at different axial and angular positions of the dermal regions of the human limb. The model incorporates the effect of blood mass flow rate, metabolic...
Article
The study of calcium diffusion in neuron cells has gained interest among research workers during the last two decades, due to its wide variety of roles in human body like muscle contraction, secretion, metabolism, signal transduction etc. Na+ is the first ion that comes in the hierarchy of ions affecting cytosolic Ca2+ concentration. This Na+ ion h...
Article
Thermoregulation is a complex mechanism regulating heat production within the body (chemical thermoregulation) and heat exchange between the body and the environment (physical thermoregulation) in such a way that the heat exchange is balanced and deep body temperatures are relatively stable. The external heat transfer mechanisms are radiation, cond...
Article
Full-text available
Temperature being a very special variable but not a specific property of the body results only from the thermal equilibrium between a body and its environment. The presence of abnormalities like tumors in human body organs can cause thermal stress and disturb this thermal equilibrium. In view of above a two dimensional finite element model has been...
Article
Fibroblasts are responsible for wound repair, remodeling and growth. The specific spatio-temporal calcium concentration patterns are required by the fibroblasts to maintain their structure and functions. Thus, calcium concentration is regulated at different levels in various activities of the cell. In order to understand the mechanisms of wound rep...
Article
A fundamental approach for studying cellular signaling is the combination of experimental findings and mathematical models. This approach provides a powerful tool to clarify the very complex mechanisms involved in cellular calcium signaling. Here an attempt has been made to develop a two dimensional model of calcium dynamics in a cylindrical shaped...
Article
In this paper, Finite element approach using two-dimensional unsteady state problem has been developed to study radial and angular calcium di�usion problem in neurons. Calcium is responsible messenger for transmit information in communication process between neurons. The most important Ca2+ binding proteins for the dynamics of Ca2+ is itself bu�er...
Article
The investigators in the past have developed some models of temperature distribution in the human limb assuming it as a regular circular or elliptical tapered cylinder. But in reality the limb is not of regular tapered cylindrical shape. The radius and eccentricity is not same throughout the limb. In view of above a model of temperature distributio...
Article
Calcium is known to play an important role in various circular functions like muscle contraction, secretion, metabolism etc. The study of calcium dynamics in various cells like neuron cell is crucial for understanding the functions, processes involved in the cell. A number of investigations on calcium diffusion in a neuron cell are reported for one...
Article
Phylogenetic trees give the information about the vertical relationships of ancestors and descendants but phylogenetic networks are used to visualize the horizontal relationships among the different organisms. In order to predict reticulate events there is a need to construct phylogenetic networks. Here, a Linear Programming (LP) model has been dev...
Article
In this paper a finite element model is developed to study cytosolic calcium concentration distribution in astrocytes for a two-dimensional steady-state case in presence of excess buffer. The mathematical model of calcium diffusion in astrocytes leads to a boundary value problem involving elliptical partial differential equation. The model consists...
Article
Evolutionary studies have been of prime importance to life scientists since ancient times. The advancements in technology has made it possible to make available the massive amounts of genomic data. The abundance of genomic data poses new challenges for biologists, computer scientists and mathematicians to develop approaches for discovery of new rel...
Article
Dendritic spine plays an important role in calcium regulation in a neuron cell. It serves as a storage site for synaptic strength and receives input from a single synapse of axon. In order to understand the calcium dynamics in a neuron cell, it is crucial to understand the calcium dynamics in dendritic spines. In this paper, an attempt has been mad...
Article
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Astrocytes actively participate in calcium signalling in nervous system. Calcium signalling depends on cytosolic calcium concentration. Calcium itself called second messenger. Calcium ions diffuse into the cell due to concentration difference between synapse and cytosol. This process occurs in almost all type of nerve cells. Due to presence of aqua...
Conference Paper
The study of calcium diffusion in neuron cells has gained interest among researchers during the last two decades, due to its wide variety of roles in human body like muscles contraction, secretion, metabolism, signal transduction etc. Most of the theoretical investigations on calcium diffusion in neurons have been carried out for one and two dimens...
Conference Paper
Full-text available
The calcium signaling plays an important role in expansion and contraction of Myocytes. This calcium signaling is achieved by diffusion of calcium and buffering mechanisms in cardiac myocytes. In this paper an attempt has been made to develop model calcium signaling in myocytes incorporating diffusion of calcium and excess buffers. The model has be...
Article
Full-text available
Calcium is well known role for signal transduction in a neuron cell. Various processes and parameters modulate the intracellular calcium signaling process. A number of experimental and theoretical attempts are reported in the literature for study of calcium signaling in neuron cells. But still the role of various processes, components and parameter...
Article
The thermoregulation of human body has been widely studied experimentally and theoretically under normal environmental and physiological conditions. But during physical exercise the thermoregulatory functions are more critical for survival and maintenance of physical work. In view of above an attempt has been made in this paper to develop a numeric...
Article
Full-text available
In the present study the thermal model of skin and subdermal tissues (SST) of human breast have been developed. The human breast is assumed to be spherical in shape with upper hemisphere projecting out from the trunk of the body and lower hemisphere is considered to be a part of the body core. The upper hemisphere represents the breast and its SST...
Article
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Calcium dynamics is the highly responsible for intracellular electrical (action potential) and chemical (neurotransmitter) signaling in neuron cell. The Mathematical modeling of calcium dynamics in neurons lead to the reaction diffusion equation which involves the parameters like diffusion coefficient, free calcium, bound calcium, buffers and bound...
Article
Phylogenetic networks are considered as the structures that are used to understand the evolutionary pathways among the different organisms. Evolutionary relations are due to the preservence of mutations in sequences, occurred due to non-tree like events like horizontal gene transfer, Homoplasy, sexual hybridization and recombination, etc. The effec...
Article
The purpose of the present investigation is to develop a numerical model to study the effect of physical exercise on temperature distribution in peripheral layers of circular shaped human limb. The model has been developed for a one dimensional unsteady state case. The model incorporates the effect of thermal conductivity, blood mass flow rate and...
Article
Highly Pathogenic Avian Influenza (HPAI) A/H5N1 virus has posed a great threat to humans with its high rate of fatality and mortality. These viruses have different segments in its genome. The evolution of these viruses involves mutation and reassortment, where these segments are interchanged among viruses and co-infect the host called mixing vessel...
Article
Astrocyte plays a pivotal role in synaptic transmission with neuron. It maintains the ionic concentration in synapse to regulate signals from one cell to another. Calcium known as second messenger plays an important role in signal transduction. There are so many physiological processes that affect the cytosolic calcium concentration [Ca2+]i like ca...
Article
Full-text available
Most of the intra-cellular events involved in the initiation and propagation phases of this process has now been identified astrocytes. The control of the spread of intracellular calcium signaling has been demonstrated to occur at several levels including IP3 receptors, intracellular Ca2+ stores like endoplasmic reticulum (ER) . In normal and patho...
Article
Astrocytes are also known to express voltage-gated Ca 2+ channels similar to those found in neurons. Calcium [Ca 2+ ] is a second messenger which plays an important role in signal transduction. The main objective of this paper is to study effect of voltage-gated calcium channel on cytosolic calcium concen-tration in astrocytes. In view of above a m...
Article
Astrocytes are directly involved in synaptic processes, and may more actively contribute to the information processing in the brain than pre-viously thought. Ca 2+ signalling appears to provide the most versatile and crucial mechanisms for such a glial contribution. Intracellular calcium distri-bution is responsible to maintaining the cellular meta...
Article
Fibroblasts are considered as a basic cell in wound repair. Regulation of cell proliferation and the cell productivity are important mechanisms involved in wound repair, which are still controversial. These mechanisms largely depend on the changes in cytosolic calcium concentration. Here an attempt has been made to study the variation of calcium co...
Article
Full-text available
Calcium is the second messenger which plays an important role in communication process in neuron cells. The region in neuron cells where the flow of electric current cannot take place in the main region of activity for chemical signaling. The chemical signaling process is achieved by the diffusion of calcium. In view of above a mathematical model o...
Article
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Mathematical and computational modeling of calcium signalling in astrocytes has produced considerable insights into how the astrocytes contracts with other cells under the variation of biophysical and physio-logical parameters. The modeling of calcium signaling in astrocytes has become more sophisticated. The modeling effort has provided insight to...
Article
Calcium [Ca 2+] dynamics is studied as a potential form of neuron excitability that can control many irregular processes like metabolism, secretion etc. Ca 2+ ion enters presynaptic terminal and increases the synaptic strength and thus triggers the neurotransmitter release. The modeling and analysis of calcium dynamics in neuron cell becomes necess...
Article
Mathematical and computational modeling of calcium signalling in nerve cells has produced considerable insights into how the cells contracts with other cells under the variation of biophysical and physiological parameters. The modeling of calcium signaling in astrocytes has become more sophisticated. The modeling effort has provided insight to unde...
Article
Full-text available
Metalloproteinases (MP) are a family of proteases which play a major role not only in normal physiological processes like normal turnover of extracellular matrix macromolecules but also in diseased conditions such as arthritis, cancer, brain disorders, skeletal dysplasias, coronary artery and heart disease. Members of the matrix metalloproteinases...
Article
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The linear problem for cytosolic calcium distribution have been obtained in the form of advection diffusion equation. The classical solution of advection diffusion equation of cytosolic calcium concentration distribution is obtained in form of error function and deduced the equation in case of incompressible cytosolic calcium distribution.
Article
In this paper a three-dimensional steady state model has been developed to study heat flow in dermal regions of tapered shape human limbs, which are elliptical in shape. The model incorporates the important biophysical parameters like blood mass flow rate, thermal conductivity and rate of metabolic heat generation. Appropriate boundary conditions h...
Conference Paper
Full-text available
HIV is human immunodeficiency virus causes AIDS (acquired immunodeficiency syndrome) which leads to life threatening opportunistic infections. HIV-1 has three groups M, N, O known worldwide. Group M is widely distributed as it has nine subtypes and circulating recombinant forms are also developed due to rapid recombination and mutation. They play a...
Article
In this paper an algorithm is proposed for mining multidimensional association rules. A Boolean Matrix based approach has been employed to discover frequent itemsets, the items forming a rule come from different dimensions. It is an algorithm for mining multidimensional association rules from relational databases. The algorithm adopts Boolean relat...
Article
The cyclin-dependent kinases (Cdks) are a family of serine/threonine protein kinases whose members are small proteins (~34-40 kDa) composed of little more than the catalytic core shared by all protein kinases. All Cdks share the feature that their enzymatic activation requires the binding of a regulatory cyclin subunit. Various combination of both...
Article
In this paper, we present an algorithm of mining hybrid dimension association rules which satisfies the definite condition on the basis of multidimensional transaction database. Boolean hatrix based approach has been employed to generate frequent itemsets in multidimensional transaction databases. It adopts Boolean relational calculus to discover f...
Article
Calcium [Ca2+] is an important second messenger which plays an important role in signal transduction. There are several parameters that affect its concentration profile like buffer source etc. The effect of stationary immobile buffer on Ca2+ concentration has been incorporated which is a very important parameter needed to be taken into account in o...
Article
Full-text available
The MMPs and ADAMs are cell surface proteases which belong to metalloprotease family. They play an important role in skin aging, skin disorders, anticancer therapy and other physiological disorders. Thus there arises the need to understand the relationships among various parameters of these proteins for prediction of their classes, structures and f...
Article
Full-text available
The present paper deals with the two dimensional model of thermal distribution in dermal layers of elliptical shaped human limbs involving two uniformly perfused tumor. Here the tumor is characterized by uncontrolled rates of metabolic heat generation. The normal tissues are characterized by self controlled metabolic heat generation. It is assumed...
Article
Full-text available
Multidimensional association rule mining searches for interesting relationship among the values from different dimensions or attributes in a relational database. In this method the correlation is among set of dimensions i.e., the items forming a rule come from different dimensions. Therefore each dimension should be partitioned at the fuzzy set lev...
Article
Full-text available
The present paper deals with the two dimensional model of thermal distribution problem in dermal layers of elliptical shaped human limbs involving a uniformly perfused tumor. The human limbs are non homogeneous and composite in nature. The structure of the region has been taken into account by dividing the dermal region of the human limb into five...
Article
Full-text available
A number of attempts have been made to study heat flow in cir-cular cross-section of human limbs. But almost no attempt has been reported in literature about study of heat flow in the tissue layers of ellip-tical shaped human limbs. Therefore, a seminumerical model has been developed to study heat flow in peripheral layers of three-dimensional elli...
Article
The present study is concerned with the two dimensional steady state heat distribution problem in in vivo tissues of cylindrical regions resembling human limbs. The model incorporates the effect of blood mass flow rate, thermal conductivity and rate of metabolic heat generation. The core temperature of the limb at inner boundary is taken as variabl...
Article
A finite element model using two-dimensional coaxial circular sector elements has been developed to study radial and angular heat distribution problem in dermal regions of human limbs. The dermal region is made up of three layers, namely epidermis, dermis, and subcutaneous tissues. The muscles, bones, major blood vessels and fats form the inner cor...
Article
The purpose of this investigation is to study the temperature distribution in in-vivo annular tissue layers of a human or animal body. The model has been developed for a two-dimensional steady state case and it incorporates the effect of important parameters like blood mass flow rate, rate of metabolic heat generation and thermal conductivity. As a...
Article
A one-dimensional steady state heat flow problem in peripheral tissue layers of a human body involving a solid tumor has been investigated. The dermis is assumed to have a nonuniformly perfused tumor. The tumor consists of a periphery and inner core. The mathematical model incorporates the effect of various physiological and physical parameters lik...
Article
We propose an efficient technique for mining frequent itemsets in large databases making use of Optical Neural Network Model. It eliminates the need to generate candidate sets and joining them for finding frequent itemsets for association rule mining. Since optical neural network performs many computations simultaneously, the time complexity is ver...
Article
Full-text available
The present paper deals with the thermal effect model of temperature distribution in dermal layers of elliptical shaped human limbs involving two uniformly perfused tumor in dermis layer. Here the tumor is characterized by uncontrolled rates of metabolic heat generation. The normal tissues are characterized by self controlled metabolic heat generat...

Citations

... The interdependent effect of calcium and buffer dynamics was also examined. Kothiya et al. [35][36][37][38] studied the system dynamics of calcium in a fibroblast cell. Vaishali et al. [39,40] studied calcium dynamics in pancreatic β cells. ...
... Kothiya et al. [35][36][37][38] studied the system dynamics of calcium in a fibroblast cell. Vaishali et al. [39,40] studied calcium dynamics in pancreatic β cells. ...
... Pawar and Pardasani [53] studied fractional-order interdependent nonlinear chaotic spatiotemporal calcium and -amyloid (A ) dynamics in neuron cells. The fractional-order reaction-diffusion model of calcium regulating NFAT production in T lymphocytes was developed by Bhardwaj and Adlakha [54]. Pawar and Pardasani [55] focused on a fractionalorder reaction-diffusion model to investigate the dysregulatory impacts of superdiffusion and memory on neuronal calcium and IP 3 dynamics. ...
... Kotwani et al. [7,12,13]; Hemant et al. [14,15]; Naik et al. [8,[16][17][18][19][20][21][22]; Pathak et al. [10,23] and Jha et al. [24,25] studied calcium distribution involving various parameters such as excess buffer, RyR, voltage-gated calcium channels, etc. for fibroblasts, lymphocytes, oocytes, myocytes, and astrocytes, respectively. Panday et al. [9,26] devised a model for Ca 2+ dynamics in oocytes that took into account Ca 2+ advection within the cell. ...
... The significance of the interdependence of the Ca 2+ and IP 3 mechanisms in the regulation of nitric oxide and −amyloid in neurons was studied by Pawar and Pardasani [43,44]. The two-way feedback model between Ca 2+ and IP 3 kinetics on nitric oxide regulation in fibroblasts with fibrotic disorders is studied by Kothiya and Adlakha [45]. ...
... Kotwani et al. [7,12,13]; Hemant et al. [14,15]; Naik et al. [8,[16][17][18][19][20][21][22]; Pathak et al. [10,23] and Jha et al. [24,25] studied calcium distribution involving various parameters such as excess buffer, RyR, voltage-gated calcium channels, etc. for fibroblasts, lymphocytes, oocytes, myocytes, and astrocytes, respectively. Panday et al. [9,26] devised a model for Ca 2+ dynamics in oocytes that took into account Ca 2+ advection within the cell. ...
... The heat equation findings with and without the source term are thoroughly contrasted, and it is discovered that the temperature distribution of the 1D steady-state heat equation with the source term is parabolic, while the temperature distribution without the source term is linear. This research, Makrariya et al. [50], presents a thermal investigation of the three-dimensional spatial temperature of the female breast at various phases of development. They also included several bio-physical processes such as metabolic heat production, blood mass flow rate, and thermal conduction in the proposed model and observed experimental results at varied ambient temperatures. ...
... Furthermore, Kumari et al. 13 proposed a FEM model to assess the thermal stress experienced by the outer regions of human limbs during periods of both exercise and rest. Their research also involved the creation of numerical models to investigate temperature distribution in the external regions of the human body before, during, and after exercise, as evidenced by their work spanning references [13][14][15] . Additionally, they pioneered the development of two-dimensional 16 and three-dimensional 14 models to quantify the temperature distribution within the external layers of human limbs immediately following physical exercise. ...
... Kotwani et al. [7,12,13]; Hemant et al. [14,15]; Naik et al. [8,[16][17][18][19][20][21][22]; Pathak et al. [10,23] and Jha et al. [24,25] studied calcium distribution involving various parameters such as excess buffer, RyR, voltage-gated calcium channels, etc. for fibroblasts, lymphocytes, oocytes, myocytes, and astrocytes, respectively. Panday et al. [9,26] devised a model for Ca 2+ dynamics in oocytes that took into account Ca 2+ advection within the cell. ...
... where ρ, c, k are the density, specific heat and thermal conductivity of tissue respectively, T b is arterial blood temperature, t is time, c b is the specific heat of blood, w is the perfusion rate per unit volume of the blood, Q m is the metabolic heat generation per unit volume. The most recent work using an explicit form of finite difference method for estimating the temperature variation in human dermal regions has been studied by Khanday and Fida (Khanday & Fida (2015)) and the temperature variation in the human body along with tumour conditions have been studied recently (Babita & Neeru (2018), Kamangar et al. (2019), Khalid et al. (2017)). However, due to the complex vascular structure in particular and whole body in general,always paves a way for the researchers to improve the existing theoretical models for better understanding and for accurate clinical results. ...