Naveed Sattar's research while affiliated with Cancer Research UK and other places
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Publications (1,000)
The association between type 2 diabetes mellitus (T2DM) and heart failure (HF) has been firmly established; however, the entity of diabetic myocardial disorder (previously called diabetic cardiomyopathy) remains a matter of debate. Diabetic myocardial disorder was originally described as the occurrence of myocardial structural/functional abnormalit...
OBJECTIVE
In this study we examine whether hospitalized coronavirus disease 2019 (COVID-19) pneumonia increases long-term cardiovascular mortality more than other hospitalized pneumonias in people with type 2 diabetes and aim to quantify the relative cardiovascular disease (CVD) mortality risks associated with COVID-19 versus non-COVID-19 pneumonia...
South Asians (SAs) have a higher risk of developing type 2 diabetes (T2D) than white Europeans, especially following gestational diabetes mellitus (GDM). Despite similar blood glucose levels post-GDM, SAs exhibit more insulin resistance (IR) than Nordics, though the underlying mechanisms are unclear. This study aimed to assess markers of adipose ti...
Aim
The 2021 European Society of Cardiology prevention guidelines recommend the use of (lifetime) risk prediction models to aid decisions regarding initiation of prevention. We aimed to update and systematically recalibrate the LIFEtime-perspective CardioVascular Disease (LIFE-CVD) model to four European risk regions for the estimation of lifetime...
Aims
Patients with a reduced left ventricular ejection fraction (LVEF) following an acute myocardial infarction (MI) are at risk of progressive adverse cardiac remodelling that can lead to the development of heart failure and death. The early addition of a sodium‐glucose cotransporter 2 (SGLT2) inhibitor to standard treatment may delay or prevent p...
Background
Pre-existing cardiovascular disease (CVD) or cardiovascular risk factors have been associated with an increased risk of complications following hospitalisation with COVID-19, but their impact on the rate of recovery following discharge is not known.
Objectives
To determine whether the rate of patient-perceived recovery following hospita...
Background
Sensory changes due to aging or disease can impact brain tissue. This study aims to investigate the link between glaucoma, a leading cause of blindness, and alterations in brain connections.
Methods
We analyzed diffusion MRI measurements of white matter tissue in a large group, consisting of 905 glaucoma patients (aged 49-80) and 5292 h...
One in ten severe acute respiratory syndrome coronavirus 2 infections result in prolonged symptoms termed long coronavirus disease (COVID), yet disease phenotypes and mechanisms are poorly understood ¹ . Here we profiled 368 plasma proteins in 657 participants ≥3 months following hospitalization. Of these, 426 had at least one long COVID symptom an...
Aims
Insulin‐like growth factor binding protein‐7 (IGFBP7) is a biomarker of tissue senescence with a role in cardio‐renal pathophysiology. The role of IGFBP7 as a prognostic biomarker across the full ejection fraction (EF) spectrum of heart failure (HF) remains less well understood. We examined associations between IGFBP7 and risk of cardio‐renal...
Aims
Both low and high body mass index (BMI) are associated with poor heart failure outcomes. Whether BMI modifies benefits of sodium–glucose cotransporter 2 inhibitors (SGLT2i) in heart failure with preserved ejection fraction (HFpEF) requires further investigation.
Methods and results
Using EMPEROR‐Preserved data, the effects of empagliflozin ve...
Purpose of Review
Obesity is associated with cardiovascular (CV) conditions, including but not limited to atherosclerotic disease, heart failure, and atrial fibrillation. Despite this, the impact of intentional weight loss on CV outcomes for persons with obesity and established CV conditions remains poorly studied. New and emerging pharmacologic th...
Associations between obesity and health are unequivocal and coupled with a substantial body of evidence suggesting that associations are likely causal. These associations and the supporting causal evidence are useful, but hide both the inadequacies of the measures used to qualify obesity and the mechanisms that are responsible for the observable re...
We aimed to unravel the mechanisms connecting adiposity to type 2 diabetes. We used MR-Clust to cluster independent genetic variants associated with body fat percentage (388 variants) and BMI (540 variants) based on their impact on type 2 diabetes. We identified five clusters of adiposity-increasing alleles associated with higher type 2 diabetes ri...
Background: The definition of metabolically healthy and unhealthy obesity for cancer risk remains uncertain and controversial. This study proposed a novel classifier based on biomarkers selected using machine learning (ML) and compared its risk stratification with the conventional definition.
Methods: A prospective cohort study was conducted of 317...
Cardio-kidney-metabolic (CKM) syndrome is defined by the American Heart Association as the intersection between metabolic, renal and cardiovascular disease. Understanding the contemporary estimates of CKM related mortality and recent trends in the US is essential for developing targeted public interventions.
We collected state-level and county-leve...
Introduction
We aimed to understand the impact of being a healthcare worker on the progression and outcomes of illness in individuals hospitalised because of post-COVID-19 complications.
Materials and Methods
The CISCO-19 study included patients hospitalised with COVID-19 and assessed baseline characteristics at index and multi-system phenotyping...
Aims
To develop and externally validate the LIFE‐T1D model for the estimation of lifetime and 10‐year risk of cardiovascular disease (CVD) in individuals with type 1 diabetes.
Materials and Methods
A sex‐specific competing risk‐adjusted Cox proportional hazards model was derived in individuals with type 1 diabetes without prior CVD from the Swedis...
Background The persistence of symptoms for ≥12 weeks after a COVID-19 infection is known as Long COVID (LC), a condition with unclear pathophysiology and no proven treatments to date. Living with obesity is a risk factor for LC and has symptoms which may overlap with and aggravate LC. Methods ReDIRECT is a remotely delivered trial assessing whether...
Aim
Vascular congestion may lead to an increase of carbohydrate antigen 125 (CA-125). The role of CA-125 as a biomarker of congestion or for prognosis across the full ejection fraction (EF) spectrum of chronic heart failure (HF) remains unknown.
Methods and results
Serum CA-125 was measured in 1111 study participants from the EMPEROR-Reduced and E...
Background
Few studies have explored long-term trends and risk factors for peripheral arterial complications in type 2 diabetes compared to the general population. Our research focuses on identifying optimal risk factors, their significance, risk associated with multifactorial risk factor control, and trends for these complications in diabetic pati...
Background
Amblyopia is a common neurodevelopmental condition and leading cause of childhood visual impairment. Given the known association between neurodevelopmental impairment and cardiometabolic dysfunction in later life, we investigated whether children with amblyopia have increased risk of cardiometabolic disorders in adult life.
Methods
This...
Background
Previous meta-analyses of summary data from randomised controlled trials have shown that statin therapy increases the risk of diabetes, but less is known about the size or timing of this effect, or who is at greatest risk. We aimed to address these gaps in knowledge through analysis of individual participant data from large, long-term, r...
Background
The associations between deprivation and illness trajectory after hospitalisation for coronavirus disease-19 (COVID-19) are uncertain.
Methods
A prospective, multicentre cohort study was conducted on post-COVID-19 patients, enrolled either in-hospital or shortly post-discharge. Two evaluations were carried out: an initial assessment and...
In high-income countries, rates of atherosclerotic complications in type 2 diabetes have declined markedly over time due to better management of traditional risk factors including lipids, blood pressure and glycemia levels. Population-wide reductions in smoking have also helped lower atherosclerotic complications and so reduce premature mortality i...
Aims/hypothesis
A precision medicine approach in type 2 diabetes could enhance targeting specific glucose-lowering therapies to individual patients most likely to benefit. We aimed to use the recently developed Bayesian causal forest (BCF) method to develop and validate an individualised treatment selection algorithm for two major type 2 diabetes d...
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% n...
Background
Patients with type 2 diabetes are at risk of heart failure hospitalization. As social determinants of health are rarely included in risk models, we validated and recalibrated the WATCH-DM score in a diverse patient-group using their social deprivation index (SDI).
Methods
We identified US Veterans with type 2 diabetes without heart fail...
Background
Observational studies on long-term trends, risk factor association and importance are scarce for type 1 diabetes mellitus and peripheral arterial outcomes. We set out to investigate trends in non-coronary complications and their relationships with cardiovascular risk factors in persons with type 1 diabetes mellitus compared to matched co...
BACKGROUND
Cardiovascular disease (CVD) is among the leading causes of death worldwide. The discovery of new omics biomarkers could help to improve risk stratification algorithms and expand our understanding of molecular pathways contributing to the disease. Here, ASSIGN—a cardiovascular risk prediction tool recommended for use in Scotland—was exam...
Background
Type 2 diabetes is associated with higher risk of several cancer types. However, the biological intermediates driving this relationship are not fully understood. As novel interventions for treating and managing type 2 diabetes become increasingly available, whether they also disrupt the pathways leading to increased cancer risk is curren...
Purpose
Periodontitis, a ubiquitous severe gum disease affecting the teeth and surrounding alveolar bone, can heighten systemic inflammation. We investigated the association between very severe periodontitis and early biomarkers of age-related macular degeneration (AMD), in individuals with no eye disease.
Design
Cross-sectional analysis of the pr...
Background
People from South Asian heritage are at high risk of type 2 diabetes, but there are limited specific strategies to prevent and manage this condition. The aim was to assess the effectiveness of culturally bespoke lifestyle programmes in South Asians that target weight loss for the prevention or remission of type 2 diabetes mellitus (T2DM)...
Purpose of Review
Obesity is a major driver of heart failure (HF) incidence, and aggravates its pathophysiology. We summarized key reported and ongoing randomized clinical trials of appetite regulation and/or dietary energy restriction in individuals with HF.
Recent Findings
Weight loss can be achieved by structured supervised diet programs with b...
Microvascular angina, linked to endothelin system dysregulation, was the focus of this double-blind, placebo-controlled, randomized, sequential crossover trial (NCT04097314). The trial compared zibotentan, an oral endothelin A receptor selective antagonist, with placebo in 118 patients with microvascular angina. Over 12 weeks, participants received...
Aims
To estimate the incidence of a major adverse cardiovascular event (MACE) and a composite kidney outcome across estimated glomerular filtration rate (eGFR) and urine albumin‐to‐creatinine ratio (UACR) levels, and to determine whether efpeglenatide's effect varies with these indices.
Materials and Methods
AMPLITUDE‐O trial data were used to est...
Background
Angiopoietin 2 regulates endothelial function partially mediated by vascular endothelial growth factor (VEGF-A) and may play a role in diabetic kidney disease. We assessed the association of angiopoietin 2 and VEGF-A with cardiorenal outcomes and investigated the effect of canagliflozin on angiopoietin 2 and VEGF-A concentrations.
Metho...
Background
Lower circulating vitamin D 25-hydroxyvitamin D (25(OH)D) concentrations are associated with higher type 2 diabetes risk in adults, although causality remains uncertain. However, associations between 25(OH)D and type 2 diabetes risk markers in children have been little studied, particularly in ethnic minority populations. We examined whe...
Importance
The effect of continued treatment with tirzepatide on maintaining initial weight reduction is unknown.
Objective
To assess the effect of tirzepatide, with diet and physical activity, on the maintenance of weight reduction.
Design, Setting, and Participants
This phase 3, randomized withdrawal clinical trial conducted at 70 sites in 4 co...
Background
Many studies have investigated whether single cardiac biomarkers improve cardiovascular risk prediction for primary prevention but whether a combined approach could further improve risk prediction is unclear. We aimed to test a sex-specific, combined cardiac biomarker approach for cardiovascular risk prediction.
Methods
In the Generatio...
Background: The COVID-19 pandemic reduced incident prescriptions for preventative cardiovascular disease (CVD) medicines, which could in part be related to reduced risk factor measurements. We examined to what extent the number of measurements of cardiometabolic risk factors (e.g., blood pressure, cholesterol, HbA1c) were impacted by the COVID-19 p...
Background
Randomized trials of vitamin D supplementation for cardiovascular disease and all-cause mortality have generally reported null findings. However, generalizability of results to individuals with low vitamin D status is unclear. We characterized dose—response relationships between 25-hydroxyvitamin D [25(OH)D] concentrations and risk of co...
Background
Extracellular matrix remodeling is one of the key pathways involved in heart failure (HF) progression. SGLT2 inhibitors may have a role in attenuating myocardial fibrosis. The impact of SGLT2 inhibitors on blood markers of collagen turnover in humans is not fully elucidated.
Aims
To investigate the effect of empagliflozin on serum marke...
Thousands of proteins circulate in the bloodstream; identifying those which associate with weight and intervention-induced weight loss may help explain mechanisms of diseases associated with adiposity. We aimed to identify consistent protein signatures of weight loss across independent studies capturing changes in body mass index (BMI). We analysed...
Background
Growth differentiation factor 15 (GDF‐15) is upregulated in part in response to cardiomyocyte stretch and stress, and it exerts a protective role that is mediated by its action to suppress signaling through insulin‐like growth factor (IGF) and enhance signaling through adenosine monophosphate‐activated protein kinase (AMPK). Sodium gluco...
Introduction: In SURMOUNT-1, treatment with once weekly GIP and GLP-1 receptor agonist tirzepatide resulted in substantial body weight reductions in people living with obesity.
Hypothesis: This post hoc analysis assessed whether participants with obesity (body mass index [BMI] ≥30 kg/m ² ) or overweight (BMI ≥27 kg/m ² with at least one weight-rela...
Introduction: Evidence suggests that inflammation is causally related to ASCVD. Elevated levels of high-sensitivity C-reactive protein (hsCRP) may identify individuals most likely to benefit from emerging anti-inflammatory therapies but hsCRP is not measured routinely in clinical practice.
Aims: To identify potential risk factors indicating elevate...
Introduction: Inflammation plays an important pathophysiological role in the development and progression of heart failure (HF). Interleukin-6 (IL-6) is a circulating cytokine which is the main regulator of the release of C-reactive protein (CRP) along with pro-inflammatory cytokines. It has been suggested that one of the potential mechanisms of act...
Background: Higher plasma concentrations of angiopoietin 2 (ANGPT2) are associated with higher risk for hospitalization for heart failure (HF) and death in univariate analyses. However, the independent association of this ANGPT2 after adjustment for clinical factors or clinically available biomarkers is not known.
Methods: High throughput proteomic...
Background: Tirzepatide (TZP) is a GIP/GLP-1 receptor agonist indicated for the treatment of type 2 diabetes and in development for chronic weight management. In SURMOUNT-1, in participants with obesity or overweight, TZP 5, 10 and 15 mg reduced body weight (-15 to -20.9%), SBP (-7 to -8.2 mmHg) and DBP (-4.6 to -5.5 mmHg) after 72 weeks of interve...
Introduction: Tirzepatide is a once weekly GIP and GLP-1 receptor agonist approved for the treatment of type 2 diabetes and under investigation for chronic weight management. In SURMOUNT-1, tirzepatide treatment resulted in substantial body weight reductions in people with obesity (body mass index (BMI) ≥30 kg/m ² ) or overweight (BMI ≥27 kg/m ² )....
Background: Patients (pts) with type 2 diabetes mellitus (T2DM) are at greater risk for major adverse cardiovascular events (MACE; e.g. stroke, myocardial infarction, and cardiovascular death). Given marked heterogeneity of risk, better multi-marker models are required to improve risk prediction.
Methods: We evaluated 5473 pts with T2DM in the EXSC...
Chronic inflammation is a hallmark of ageing and age–related disease states. The effectiveness of inflammatory proteins such as C–reactive protein (CRP) in assessing long–term inflammation is hindered by their phasic nature. DNA methylation (DNAm) signatures of CRP may act as more reliable markers of chronic inflammation. We show that inter–individ...
OBJECTIVE
To investigate to what extent having control of peripheral artery disease (PAD) risk factors is associated with the risk of incident PAD in individuals with type 2 diabetes.
RESEARCH DESIGN AND METHODS
A total of 148,096 individuals with type 2 diabetes in the Swedish National Diabetes Register between 2005 and 2009 were included and mat...
Background
We tested the potential of the Secondary Manifestations of Arterial Disease (SMART2) risk score for use in patients undergoing coronary artery bypass grafting.
Methods and Results
We conducted an external validation of the SMART2 score in a racially diverse high‐risk national cohort (2010–2019) that underwent isolated coronary artery by...
Aims/hypothesis
High-throughput metabolomics technologies in a variety of study designs have demonstrated a consistent metabolomic signature of overweight and type 2 diabetes. However, the extent to which these metabolomic patterns can be reversed with weight loss and diabetes remission has been weakly investigated. We aimed to characterise the met...
Context:
With age, the prevalence of subclinical hypothyroidism rises. However, incidence and determinants of spontaneous normalization remain largely unknown.
Objective:
To investigate incidence and determinants of spontaneous normalization of thyroid-stimulating hormone (TSH) levels in older adults with subclinical hypothyroidism.
Design:
Po...
Background: Plasma growth differentiation factor 15 (GDF15) and Nterminal proBtype natriuretic peptide (NTproBNP) are cardiovascular biomarkers that associate with a range of diseases. Epigenetic scores (EpiScores) for GDF15 and NTproBNP may provide new routes for risk stratification.
Results: In the Generation Scotland cohort (N ≥ 16,963), GDF15 l...
Mendelian randomization (MR) is a widely used method that exploits the unique properties of germline genetic variation to strengthen causal inference in relationships between exposures and outcomes. Nonlinear MR allows estimation of the shape of these relationships. In a previous paper, the authors applied linear and nonlinear MR to estimate the ef...
OBJECTIVE
To identify predictors of body weight (BW) reduction of ≥15% with tirzepatide treatment and to describe associated clinical parameters of participants with type 2 diabetes (T2D) who achieved different categorical measures of BW reduction (<5%, ≥5 to <10%, ≥10 to <15%, and ≥15%) across four studies from the phase 3 SURPASS clinical trial p...
paragraph
Heart failure (HF), a syndrome of symptomatic fluid overload due to cardiac dysfunction, is the most rapidly growing cardiovascular disorder. Despite recent advances, mortality and morbidity remain high and treatment innovation is challenged by limited understanding of aetiology in relation to disease subtypes. Here we harness the de-conf...
Background
The multisystem associations between baseline mental health status and coronavirus disease-19 (COVID)-19 illness trajectory are uncertain.
Objectives
This article will investigate the associations between baseline mental health status and disease trajectory following COVID-19 hospitalization, which may have implications for practice and...
OBJECTIVE
To determine the extent to which changes in plasma proteins, previously predictive of cardiometabolic outcomes, predict changes in two diabetes remission trials.
RESEARCH DESIGN AND METHODS
We applied SomaSignal predictive tests (each derived from ∼5,000 plasma protein measurements using aptamer-based proteomics assay) to baseline and 1-...
Background and aims
Randomised controlled trials (RCTs) have assessed the effects of renin-angiotensin system (RAS) blockers in adults with COVID-19. This meta-analysis provides estimates of the safety and efficacy of treatment with (versus without) RAS blockers from these trials.
Methods
PubMed, Web of Science, and ClinicalTrials.gov were searche...
Objective
The study aim was to investigate associations of 11 anthropometric measures with incident type 2 diabetes and compare their predictive performance.
Methods
This prospective cohort study included 161,127 White European UK Biobank participants who were free of diabetes at baseline. Anthropometric measures included height, weight, BMI, A Bo...
Importance
Calcium channel blocker (CCB) use has been associated with an increased risk of glaucoma in exploratory studies.
Objective
To examine the association of systemic CCB use with glaucoma and related traits among UK Biobank participants.
Design, Setting, and Participants
This population-based cross-sectional study included UK Biobank parti...
Post-COVID cognitive deficits, including ‘brain fog’, are clinically complex, with both objective and subjective components. They are common and debilitating, and can affect the ability to work, yet their biological underpinnings remain unknown. In this prospective cohort study of 1,837 adults hospitalized with COVID-19, we identified two distinct...
IntroductionThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus (coronavirus disease 2019 [COVID-19]) pandemic revealed the vulnerability of specific population groups in relation to susceptibility to acute deterioration in their health, including hospital admission and mortality. There is less data on outcomes for people with ty...
Background:
People with type 2 diabetes and albuminuria are at an elevated risk for cardiac and renal events. The optimal biomarkers to aid disease prediction and to understand the benefits of sodium-glucose cotransporter-2 inhibition remain unclear.
Methods:
Among 2627 study participants in the CREDENCE trial (Canagliflozin and Renal Events in...
Objective:
To investigate the causal association of type 2 diabetes and its components with risk of vascular complications independent of shared risk factors obesity and hypertension and to identify the main driver of this risk.
Research design and methods:
We conducted Mendelian randomization (MR) using independent genetic variants previously a...
Background:
Post-COVID-19 syndromes have associated with female sex, but the pathophysiological basis is uncertain.
Aim:
There are sex differences in myocardial inflammation identified using cardiac magnetic resonance (CMR) in post-COVID-19 patients, and in patient reported health outcomes following COVID-19 infection.
Design:
This prospective...
Metabolic mechanisms underlying the heterogeneity of major adverse cardiovascular events (MACE) risk in individuals with type 2 diabetes mellitus (T2D) remain unclear. We hypothesized that circulating metabolites reflecting mitochondrial dysfunction predict incident MACE in T2D. Targeted mass-spectrometry profiling of 60 metabolites was performed o...
A precision medicine approach in type 2 diabetes (T2D) could enhance targeting specific glucose-lowering therapies to individual patients most likely to benefit. We utilised Bayesian non-parametric modelling to develop and validate an individualised treatment selection algorithm for two major T2D drug classes, SGLT2-inhibitors (SGLT2i) and GLP1-rec...
Objectives: The Remote Diet Intervention to Reduce Long COVID Symptoms Trial (ReDIRECT) evaluates whether the digitally delivered, evidence-based, cost-effective Counterweight-Plus weight management programme improves symptoms of Long COVID in people with overweight/obesity.
Methods: Baseline randomised, non-blinded design with 240 participants all...
Citations
... Table S1: Selected studies evaluating the effect of SGLT2 inhibitors on physiological vascular measurements; Table S2: Selected studies evaluating the effects of SGLT2 inhibitors on inflammatory, oxidative stress and thrombosis markers; Table S3: Selected studies evaluating the effect of SGLT2 inhibitors on cardiac biomarkers; Table S4: Selected studies of SGLT2 inhibitors and renal biomarkers; Table S5: Selected studies of GLP1-RAs and the effects on physiological vascular measurements; Table S6: Effects of GLP-1 RAs on vascular and cardiac biomarkers; Table S7: (a) Completed trials for tirzepatide in T2DM patients, (b) Tirzepatide trials for obesity, (c) Ongoing tirzepatide trials; Table S8: Selected ongoing early phase or recently completed trials involving novel antidiabetic agents. References [233][234][235][236] are cited in the supplementary materials. ...
... Type 1 and type 2 diabetes mellitus are both associated with an increased risk of cardiovascular disease. [1][2][3] In this Issue of the Lancet Regional Health-Europe, two cohort studies investigated trends in non-coronary arterial complications in people with either type 1 (N = 34,263) 4 or type 2 diabetes mellitus (N = 655,250) 5 based on the Swedish National Diabetes Register (NDR) between 2001 and 2019. In addition, up to five age-, sex-, and county-matched individuals functioned as a general population comparison cohort. ...
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... Increasing evidence suggests T2D remission (i.e. reduction in HbA1c to ≤ 6.5% without the use of glucose-lowering medications) is possible for some when adopting an intensive weight management programme following diagnosis [35][36][37]. Such findings have garnered widespread scientific, health and media attention, as well as apparent interest from the broader T2D community. ...
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... Cluster specific polygenic scores in ~279,000 individuals revealed obesityrelated vascular outcomes across different ancestry group. This in turn suggests potential optimizations for global diabetes care access by leveraging genetic insights and understanding the diverse etiological factors contributing to T2D [167]. While this information provides a proximate view of the population-specific risk variant, understanding how nature has shaped the function of these variants throughout human evolution and if these variants were advantageous or deleterious in our ancestors may help us to understand what happened during the course of time that certain contemporary human population became prone to obesity and T2D while others not. ...
... As a result, this may result in a cohort that progressively comprise individuals at lower risk." 4 This issue is likely more influential for people with type 1 diabetes mellitus who were much younger when entering the Swedish NDR than people with type 2 diabetes mellitus (mean age 33 years for the former vs 64 years for the latter). 4,5 Well-treated, compliant people with type 1 diabetes mellitus have a low risk for many years and such patients will likely contribute observation time for many of the examined calendar periods. In contrast, non-compliant people with type 1 diabetes mellitus will have a high risk of events and thus a lower risk of contributing observation time to several calendar periods. ...
... A tirzepatida, um agonista dos receptores de GLP-1 e glucagon, é objeto de estudo para o tratamento da obesidade e diabetes tipo 2 (Aronne, et al., 2024;Da Silva Malveira et al., 2021). Quanto às expectativas, esperase que este medicamento promova a perda de peso em pacientes com obesidade ou sobrepeso, contribuindo também para o controle glicêmico e melhorando a sensibilidade à insulina (Chavez, 2023). ...
... 2 Having said that, some studies have suggested that NT-pro-BNP, cTnT, and GDF-15 have a stronger association with major adverse cardiac events than CRP. 3 Ultimately, prediction scores incorporating multiple biomarkers may have the greatest clinical utility, and this study adds to the overall body of evidence. ...
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... In our one-sample MR, we constructed an external weighted GRS based on 19 SNPs identified in the UK Biobank population. The 19 SNPs exhibited clear biological relevance in the transport, synthesis and metabolism of serum 25(OH)D 15 . This GRS explained a significantly greater proportion of the variation (5.6%) of serum 25(OH)D with an F statistic value Table 3. One-sample MR 1 results for the causal associations of serum 25(OH)D levels (per 25 nmol/L increase) with systolic blood pressure, diastolic blood pressure and risk of hypertension in the HUNT Study (n = 86,324). ...
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... 26 Furthermore, non-steroidal MR antagonists and sodium-glucose co-transporter-2 inhibitors have potent anti-inflammatory and antifibrotic properties. 27 Given the present findings, UPP analysis combined with measurement of circulating fibrosis biomarkers offers novel perspectives in documenting the antifibrotic properties of novel drug classes. Of note, the serum PICP decrease produced by empagliflozin in the Empagliflozin Outcome Trial in Patients with Chronic Heart Failure (EMPEROR) was of the same order of magnitude as in the current study: 5% at 12 weeks and 8% at 52 weeks. ...
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... [18][19][20][21] Additional adjustment was performed on GDF-15, another important prognostic marker in the EMPEROR programme. 22 Week 12 landmark analysis were performed to study the associations between IGFBP7 changes and the subsequent occurrence of the primary outcome. Heterogeneity of treatment effect on major HF outcomes across the groups defined by the tertiles of GDF-15 was investigated by fitting Cox regression and negative binomial models, as appropriate, adjusted by the pre-specified covariates except for hs-cTnT and NT-proBNP and including a IGFBP7 group by treatment interaction. ...
