By giving extensive coverage to important developments concerning the structure, functions and diseases of the kidneys, ëNephroní has earned its place on the reading list of every active nephrologist. Each issue contains practice-oriented findings from many fields, including anatomy, pathophysiology, biochemistry, microbiology, endocrinology, immunology and pharmacology. New diagnostic and therapeutic techniques are also featured, particularly advances in transplantation, dialysis and hemofiltration. Frequently cited papers are supported by editorials, reviews, ëGrand Rounds in Nephrologyí, ëControversies in Nephrologyí, ëSeminars in Renal Physiologyí, ëHistory of Modern Nephrologyí, short communications and case reports to provide a complete guide to progress in all aspects of nephrology, including renal disease and hypertension

Nephron

Alterations in urine concentrating ability with age were examined in 98 active community-dwelling volunteers (aged 20-79 years) who were free from evidence of diseases known to adversely affect renal function. There was a significant decrease in urine osmolality reached after 12 h dehydration with advancing age, which could not be correlated with the age-related decline in creatinine clearance. A significant age-related diminution in the ability to conserve solute was also observed. This inability to conserve solute may result in diminished medullary tonicity and impaired urinary concentrating ability.

The Influence of Age on the Renal Response to Water Deprivation in Man

Hydration Status in Older Adults: Current Knowledge and Future Challenges

Karger

The glomerular filtration rate declines approximately by half from the ages of 30 to 80 years [44]. Compared with younger adults, older people aged 60 to 79 years have an approximately 20% reduction in maximum urinary concentrating ability [45]. By age 80, there is a reduction of more than half in maximum urinary concentrating ability comparing to the youthful peak of 1100 to 1200 mOsm/kg. 

Nathan W. Shock's scientific contributions

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