Nancy L. Noble's research while affiliated with University of Miami Miller School of Medicine and other places
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Publications (3)
A small molecular weight structural glycopeptide was solubilized after collagenase digestion of the connective tissue capsule surrounding the 5-day sponge-implant of the rat. The major amino acids are one residue each of aspartic and glutamic acids, proline, hydroxyproline and alanine and two residues of glycine, and the carbohydrates are one resid...
Hydroxyproline-containing structural glycopeptide fractions were isolated from collagenase-digested neutral salt-insoluble collagen of five-day sponge-implant connective tissue of the rat. The glycopeptide fractions characterized migrate as a single, strongly anionic band on disc gel electrophoresis at pH 9.5, are eluted on gel filtration as a smal...
An extracellular lipase from Corynebacterium acnes has been partially purified and characterized. The enzyme was obtained from the crude culture broth after ultrafiltration, gel filtration through Sephadex G-100, and chromatography on CM-cellulose. This preparation demonstrates broad specificity and its activity against tri-, di-, and monoglyceride...
Citations
... Therefore, pharmacological inhibition of C. acnes producing lipase is essential to manage acne. Previously known lipase inhibitors such as phenylmethylsulfonyl fluoride, and p-chloromercuribenzoate, have shown poor efficacy and higher toxicity, not suitable for pharmacological inhibition of C. acnes lipases [25]. On the other hand, systemic antibiotics, viz., erythromycin, tetracycline, clindamycin, minocycline, tretinoin, benzoyl peroxide, and doxycycline, are widely being used for the treatment of acne causing serious detrimental side effects and increasing resistant strains of C. acnes. ...