Nai-Feng Tian's research while affiliated with First Affiliated Hospital of China Medical University and other places

... Zhang et al. discovered that pirfenidone (PFD) effectively reduced RANKL-induced osteoclastogenesis by impairing NF-κB activation and suppressing NF-κB expression (Zhang et al. 2023b). Sheng et al. demonstrated that Safranal (Saf ), a monoterpene aldehyde, attenuated osteoclast differentiation by inhibiting IκBα degradation through promoting NF-κB p65 deacetylation and inactivating IKK, thus interfering with NF-κB signaling (Sheng et al. 2023). Wu et al. identified that Strontium ranelate (SR) hindered osteoclast formation by inducing NF-κB pathway-dependent autophagy, thereby mitigating bone destruction in rats ). ...

... DNA methylation stands out for being involved in cell regulation and differentiation, considered as two of the main factors that regulate gene activities 13 . Previous studies have shown the relationship of changes in DNA methylation patterns in animal models and in patients with chronic low back pain 10,14,15,16 . In addition to the identification of genetic predisposition, knowledge of epigenetic changes involved in chronic nonspecific low back pain may contribute to the understanding and development of new treatments 17 . ...

... Degenerated CEP cells also upregulate inflammatory cytokines and may contribute to tissue calcification via the expression of hypertrophic and osteogenic markers [27,[30][31][32][33]. These cells are reminiscent of articular chondrocytes [34], and many studies assess the degenerative status of CEP cells using common markers associated with cartilage health and disease [27,32,35]; additionally, several mechanistic studies exploring non-traditional markers in CEP cells are motivated by previous findings in articular cartilage [36,37]. Despite their similarities, the CEP and articular cartilage are structurally and compositionally distinct tissues [38], and analysis of a subset of cartilage and disc genes revealed phenotypic differences between the two cell types [34]. ...

... The VAC system has also demonstrated the ability to be used for infection prophylaxis, reducing the incidence of SSIs by up to 50% after application for closed incisions [19] . There also have been demonstrations of the use of LDDS such as antibiotic cement either in the form of beads [20 , 21] or a strut graft [22] and the use of Closed Suction Irrigation Systems (CSIS), with or without drug delivery, to assist in the successful management of SSIs [23] . ...

... It allowed the development of upper limb dexterity which had significant importance in the evolution of the neocortex, and it ensured horizontal gaze which profoundly impacted interaction with the environment. 1,2 The visual field plays a fundamental role in avoiding obstacles and regulating stability at rest and in motion. 3 Horizontal gaze is a parameter of craniocervical sagittal alignment that allows the individual to safely interact with the environment, wander, and perform daily life activities. ...

... Generally, the common complications of PVP include bone cement leakage, cement embolism, intraoperative puncture injury and new fractures (8)(9)(10)(11). Bone cement leakage and embolism may cause serious adverse complications, such as pulmonary cement embolism (12)(13)(14)(15), spinal compression (16,17), neurological deficit (18,19), atrial mass cement embolism (20), and iatrogenic venous compression (21), which have attracted a lot of attention. However, there are few reports about the hemorrhage caused by vascular injury, although the bleeding may lead to shock or other serious and terrible complications. ...

... Entry point of CBT is the intersection between the midpoint of superior articular process and the horizontal line 1 mm below the inferior border of transverse process. The screw is then pointed laterally 8-9 O and 25-26 O cranially (Fig. 4B) [4]. ...

... S ACS is a rare disease that may challenge every spine surgeon. 2,4,5,[13][14][15][16] This study introduced reduction of AAS, single-door laminoplasty of atlas and atlantoaxial fusion in the treatment of SACS. We found this new method could not only completely reduce AAS but also fully enlarge the inner sagittal diameter of atlas, and achieve C1-2 fusion satisfactorily. ...

... At the same time it permits to avoid fixation of more adjacent levels and ensures a stability similar to a longer fixation, allowing to decrease posttraumatic flattening of the vertebral body compared to bridge fixation. Since then, the option of short posterior fixation with screws at the level of the fracture has become the gold standard in compression fractures and has taken on particular importance, given its additional stability, in fractures with significant somatic comminution, in which corpectomy and vertebral body replacement are not performed (20,21,22,23,24,25,26). Nevertheless, the loss of support in the anterior column, which gets 80% of all axial loads, inevitably leads to the overload of the posterior instrumentation. ...

... Vertical laminar fracture (VLF) is frequently associated with BFs and results from vertical compression forces causing energy transfer from the vertebral body to the posterior elements, leading to interpedicular widening (IPW) and vertical split of the lamina [5][6][7]. Several studies have reported the associations of VLF with neurological deficits and radiographic parameters indicators of the severity of BFs [6][7][8]. As a result, VLF is commonly recognized as a severity marker for BFs [9]. ...