N Yu Sarycheva's research while affiliated with Lomonosov Moscow State University and other places

... Our study results show that exposure to noise during early and full-term gestation causes recurrent abortion, and late gestational periods cause stillbirth, preterm birth, and congenital disabilities in newborn pups. Various studies confirmed that maternal stress causes recurrent abortion, stillbirth, preterm birth, and congenital disabilities in offspring [14][15][16][17][18]. A meta-analysis study has mentioned that high noise exposure during pregnancy increases the risk of early gestational age, gestational hypertension, and congenital disabilities in newborns [19]. ...

... One of the mechanisms involved in the regulation of Snca expression is dependent on the activity of DNA (cytosine-5)-methyltransferase 1 (DNMT1) [36]. This assumption is consistent with the previous results, which showed DNMT1 mRNA level is increased in the mesolimbic areas of adult PAE male rats [37]. Thus, our current data testifies that α-synuclein may be among the targets of prenatal alcohol and suggests that sex-specific long-term changes in Snca expression may impact the manifestation of neurobehavior disorders caused by PAE. ...

... We showed that animals of the MA group displayed decreased vertical and horizontal motor activity in the open fi eld. This is consistent with previous results obtained in animals showing decreased locomotor activity after pre-and postnatal administration of VPA [Gedzun et al., 2020;Kataoka et al., 2013;Mabunga found that reduced exploratory behavior in adult rats in the VPA model is likely to be mediated by fear-related inhibition of exploratory behavior. ...

... 1. Differences often exist in the behavioral repertoire of the species, making it unrealistic to attempt to model-specific anomalies in human behavior, e.g., amorality (Fisch 2015 ). ...

... The exposure, to a neurotoxicant agent like VPA during critical periods was found to disrupt neurobehavioral development by altering neural migration, circuitry, and/or synaptogenesis of brain areas required for expression of these behaviors, resulting in behavioral retardation, regression, and/ or intrusions (Wagner et al., 2006). According to the literature, prenatal and postnatal VPA exposures in rodents are the most commonly used models to induce autistic-like neurobehavioral defects which are analogous to the deficits observed in humans with autism (Schneider and Przewlocki, 2005;Wagner et al., 2006;Mony et al., 2016;Gedzun et al., 2017). The prenatal VPA model was introduced in 1996, when a single large dose of VPA administered to rats on gestational day 12.5 to elicit autistic-like features (Rodier et al., 1996). ...

... Peritoneal mouse macrophages isolated from the peritoneal fluid (1.5×10 6 cells in 1 ml suspension) were applied on coverslips (30 μl) and incubated in a humid chamber for 45 min at 22 o C for cell adhesion. Coverslips with attached macrophages were placed in small Petri dishes (2 ml) with Hanks solution containing 10 mmol/liter HEPES (pH 7.2) (Serva) and maintained under these conditions throughout the experiment [12]. ...

... As discussed above, increased levels of HMGB1 and DKK1 may further damage the BBB. Moreover, endomorphin 2 may cross the BBB (Chesnokova et al. 2013), and increased opioid receptor binding (MOR and KOR) on the BBB may precede its breakdown (Ting et al. 1997). ...

... The physiological impacts of opposing exorphins are still exceptionally ineffectively caught on. A few drain exorphins (casomorphins, casoxins, lactoferroxins) can not only be shaped amid the assimilation of drain within the gastrointestinal tract, but too be contained in cheeses, since the innovation for making cheese is related with enzymatic preparing [1][2][3]. ...

... Unlike the olfactory bulb, the accessory olfactory bulb bypasses the olfactory cortex and projects directly to the amygdala and hypothalamus, which are closely linked to behavior. It has been suggested that the vomeronasal and olfactory systems work in conjunction with each other and that having only one system operational could have a detrimental effect on behavior (Kudjakova, Sarycheva, and Kamenskii 2007). These results suggest that domoic acid-induced SE may disrupt olfactory processing on several levels in the rat, but leaves the vomeronasal system structurally intact for behavior-driven scent cues. ...

... The primary function of the organ is chemoreception of pheromones, and it has been shown that the organ plays a vital role in the formation of social and sexual behaviour in animals. 3,4 The vomeronasal organ was first described in humans by Dutch botanist and anatomist Frederik Ruysch in 1703 when describing and sketching the nasal septum of a young male cadaver, and was later rediscovered in 1813 by the Danish surgeon Ludwig Jacobson, after whom the organ is trivially named. 5,6 Nevertheless, the presence of the organ and its functionality in primates has been widely disputed. ...