Murilo Rocha Rodrigues's research while affiliated with Universidade São Francisco and other places

... The generation of oxidative stress occurs due to an imbalance with antioxidant enzymes, non-enzymatic antioxidants, free radicals and ROS that can damage proteins, lipids and cellular DNA (Paltrinieri 2008;Guo and DiPietro 2010;Birben et al. 2012). One of the ways to verify the occurrence of oxidative stress is by measuring its products, such as MDA, which is a bioproduct of lipid peroxidation (Vasconcelos et al. 2007;Martinez et al. 2015) and NO, which is a reactive nitrogen species generated during inflammation, which can cause excessive vasodilation and DNA damage (Soomro 2019). Also the activity of antioxidant enzymes can be measured, such as SOD and CAT, which are the primary enzymes against harmful effects, and the removal of ROS and free radicals (Case 2017), and GST, which contributes to detoxification by interrupting lipid peroxidation (Sharma et al. 2004;Hayes et al. 2005). ...

... The lack of SCFA supply, in addition to the considerable reduction in the ability of goblet cells to synthesize mucins, increases the formation of RONS. These free radicals destroy the mucus layer that covers the epithelial barrier and induce goblet cells apoptosis in the intestinal glands, triggering and exacerbating the inflammatory process that characterizes DC 15,16 . ...

... Recently, scientists have been exploring natural compounds like curcumin to find effective yet benign alternative possibilities. Animal and fish feed have benefited from turmeric's primary bioactive compound because of its immunostimulatory, antioxidant, antibacterial, and anti-inflammatory effects (Nonose et al., 2014 andGalli et al., 2018). Several studies conducted to investigate the effect of curcumin on the growth performance of birds Rahmani et al. (2017) found that mal Ross chicks fed either curcumin/nano curcumin-containing diet improved (p ≤ 0.05) body weight and gain compared to those fed control diet. ...

... Despite having a remarkable antioxidant effect, due to its low ability to adhere to the colonic mucosa, NAC requires successive enema applications, which made its use impractical 18,19 . In contrast, SCF, in addition to stimulating mucin production by goblet cells, can effectively adhere to the inflamed colonic mucosa 17,21,22 . SCF adheres firmly to the mucosa, forming a gelatinous barrier over the inflamed surface. ...

... proteins was demonstrated in the colonic segments devoid of intestinal transit, and this reduction was related to the duration of exclusion 12,17,18 . Conversely, the application of enemas containing SCFA or substances with antioxidant or anti-inflammatory activities, such as N-acetylcysteine and mesalamine, increases the tissue content of both mucins and proteins that constitute intercellular junctions, restoring epithelial integrity 2,4,7,16,18,24 . ...

... Studies have evaluated the use of different substances with antioxidant action for the treatment of DC using experimental DC models. Among them, the intrarectal application of enemas containing n-acetylcysteine (NAC) or sucralfate (SCF) showed promise 17,18 . Both substances reduced the levels of oxidative stress in the mucosa of the excluded colon, suppressed the inflammatory process, and promoted epithelial healing [17][18][19][20] . ...

... Each structure is fed by two arterioles and one venule within vascular stalks attached to the colon. These structures are commonly found on the sigmoid colon (57%), cecum (26%), ascending colon (9%), transverse colon (6%), and descending colon (2%) 7,8 . These explain the pathophysiology of left lower quadrant abdominal pain experienced by patients, as was observed in these patients. ...

... Por tratarse de malformaciones venosas de bajo flujo, debe considerarse la posibilidad de trombosis, identificada por dolor a la palpación, calor y edema en las lesiones. Otras posibles complicaciones diferentes a la hemorragia son las calcificaciones y, en casos menos frecuentes, la presencia de coagulopatía de consumo, trombocitopenia y, por supuesto, todas las complicaciones secundarias a la hemorragia según su volumen y tiempo de instauración (2,3) . ...

... Among them, the intrarectal application of enemas containing n-acetylcysteine (NAC) or sucralfate (SCF) showed promise 17,18 . Both substances reduced the levels of oxidative stress in the mucosa of the excluded colon, suppressed the inflammatory process, and promoted epithelial healing [17][18][19][20] . Despite having a remarkable antioxidant effect, due to its low ability to adhere to the colonic mucosa, NAC requires successive enema applications, which made its use impractical 18,19 . ...

... Three different types of vascular supply of ELT attached to the gallbladder were reported by Bal et al. [8] as follows: type 1, artery arising from the cystic artery [9]; type 2, vascular pedicle (with/without its own vein) arising from the liver parenchyma [8]; and type 3, vascular structures embedded in the mesentery lying from the hepatic site to the ELT [10]. The present case corresponds to type 2. It is clinically important to define ELT with a vascular supply during cholecystectomy because traction of the gallbladder may cause the rupture or tearing of the vascular structure from the liver parenchyma. ...