Murat Dizbay's research while affiliated with Gazi University and other places

... The inflammatory response in COVID-19 patients may be dramatic and referred to as cytokine storm because of the large amount of pro-inflammatory molecules released in the plasma (i.e., IL-1b, IL-2, IL-6, IL-8, IL-10, interferon-γ, and tumor necrosis factor-α or TNF-α), potentially leading to acute lung injury, subsequent acute respiratory distress syndrome, multiorgan failure, and death if immediate intensive care unit interventions are not initiated [155,156,157,158]. ...

... Quinoline is a privileged scaffold for bioactive molecules [1][2][3][4][5][6]. Shown in Figure 1 are some quinoline-containing drug molecules, including Mefloquine (antimalarial) [7][8][9][10], Brequinar (anticancer) [11][12][13], Pitavastatin (cholesterol-lowering) [14][15][16], Plaquenil (antimalarial) [17,18], Ciprofloxacin (antibacterial) [19][20][21], and Lenvatinib (anticancer) [22][23][24]. Other than these commercial drugs, a great number of quinoline derivatives have been reported or are under development as druggable molecules for anticancer [25,26], antibacterial [27][28][29], antifungal [30-32], antiviral [33][34][35][36], antimalarial [37][38][39], antioxidant [40][41][42], anti-inflammatory [43][44][45], CNS effect [46,47], cardiovascular, anticonvulsant, analgesic, and anthelmintic research [48][49][50][51]. ...

... Also, delayed treatment resulting from misdiagnosis of EPTB may lead to an increase rate of morbidity which in tend will cause the continual spreading of the disease. 5 Further more may increase the healthcare costs associated with delayed treatment and the potential for the spread of TB. This study seeks to bring to the concern of the public the misdiagnosis of extra pulmonary tuberculosis. ...

... Aysert-Yildiz et al., investigated a total number of 94 CRKP-infected patients treated with intravenous fosfomycin, and they revealed that favorable clinical response rates for combination treatments including meropenem and polymyxins as 66.6% (n=9) and 63.6% (n=11) for bacteremia; 62.5% (n=16) and 60% (n=15) for pneumonia, respectively. In addition, they showed that all of the combination treatments had a similar clinical response rates for different types of infections except the tigecycline combination for pneumonia 9 . Perdigao Neto et al., described a prospective series of 13 patients (treated with fosfomycin) who had infections (BSI, n=11) due to β-lactams and colistin-resistant gram-negative bacteria (K. ...

... HMWK is essential for blood coagulation and the release of bradykinin [30,31]. Interestingly, during SARS-CoV-2 infection, an increase in bradykinin levels is associated with lung injury and inflammation [32]. Meanwhile, ALB (Log2FC = −3.188, ...