Muhammad Arshad's research while affiliated with New York University Abu Dhabi and other places

Publications (4)

Article
Full-text available
Ferroptosis is a unique iron-dependent form of non-apoptotic cell death characterized by devastating lipid peroxidation. Whilst growing evidence suggests that ferroptosis is a type of autophagy-dependent cell death, the underlying molecular mechanisms regulating ferroptosis are largely unknown. In this study, through an unbiased RNA-sequencing scre...
Article
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Oxeiptosis is a recently identified reactive oxygen species (ROS)-sensitive, caspase independent, non-inflammatory regulated cell death pathway. The activation of Kelch-like ECH-associated protein 1-Phosphoglycerate mutase 5-Apoptosis inducing factor mitochondria associated 1 (KEAP1-PGAM5-AIFM1) pathway is the key signaling event in the execution o...
Article
Full-text available
The studies on the prevalence and genetic diversity of begomoviruses in Saudi Arabia are minimal. In this study, field-grown symptomatic tomato and muskmelon plants were collected, and initially, begomovirus infection was confirmed by the core coat protein sequences. Four tomato and two muskmelon plants with viral infections were further evaluated...

Citations

... However, under toxic levels of ROS, KEAP1 dissociates from PGAM5, and PGAM5 is internalized into mitochondria, resulting in the dephosphorylation of a serine residue at 116 of AIFM1, thereby initiating oxeiptosis [7,9,10]. Inhibition of oxeiptosis has been shown to attenuate the reduced viability caused by ROS treatment [11][12][13][14][15]. Based on these findings, we wondered if oxeiptosis is induced in NPCs and whether inhibiting oxeiptosis in NPCs could delay the progression of IVDD. ...
... In addition to TYLCD, a complex of different begomoviruses, e.g., tomato leaf curl Palampur virus (ToLCPalV), cause tomato leaf curl disease (ToLCD). ToLCPalV is a bipartite begomovirus, which was first identified in India (Kumar et al. 2008), and then reported from Iran, Pakistan, Iraq, Oman and Saudi Arabia (Heydarnejad et al. 2009;Ali et al. 2010;Mohammed et al. 2021;AlHudaib et al. 2023). In addition to tomato, ToL-CPalV naturally infects common beans (Phaseolus vulgaris; Heydarnejad et al. 2013), papaya (Carica papaya; Shahid and Al-Sadi 2022), Basella alba (Kumari et al. 2020), Rumex sp. ...