Mohamed J. Saadh's research while affiliated with Applied Science Private University and other places

... To put it in a more vivid picture, chemotherapy, which refers to applying medicines or drugs for cancer therapy, has a remarkable toxic effect on both cancerous and normal cells in the human body. Besides, the prolonged and repetitive treatment periods, administrating high drug dosage, inducing the immune system response, inducing multi-drug resistance, anemia, nausea/weight change/dietary issues, less practicality in the elderly, and unaffordability are mentioned as the considerable deficiencies of chemotherapy which sometimes result in lack of efficient treatment and mortality (Almajidi et al. 2024;Saadh et al. 2024). Moreover, surgery is another most common modality in cancer treatment which usually applies along with chemotherapy. ...

... 13,14 Indeed, a growing body of evidence has emerged in favour of a substantial miRNA dysregulation across the neurodegenerative disorders including Alzheimer's disease, 15,16 frontotemporal dementia, 17 multiple system atrophy 18 and Parkinson's disease. [19][20][21][22][23][24][25] Such a dysregulation at the epigenetic level might provide an additional insight into the pathogenesis and progression of the neurodegenerative disorders. ...

... Therefore, CS has been classified as a generally recognized as safe (GRAS) compound by the Food and Drug Administration (FDA) [3]. This is why numerous researchers have extensively followed CS or CS-based scaffolds for biomedical applications, which can be confirmed by the abundant published work based on CS [4][5][6]. ...

... The disintegration of cell nuclei suggests heightened vulnerability to damage, particularly because hepatocytes are primary agents in disseminating substances through the portal circulation from the gastrointestinal tract [36]. This vulnerability is exacerbated when the cells' nutritional status, exposure to toxins, and the duration of such exposures are compromised, or when drug interactions affect cellular membranes and ionic balances [37]. ...

... These findings imply that beyond its potential antifungal properties, chitosan could offer therapeutic benefits in correcting lipid imbalances induced by C. krusei infections or possibly by other fungal pathogens [32]. The clinical relevance of these observations lies in chitosan's potential as a complementary treatment option, not only in combating fungal infections but also in managing associated metabolic disruptions, thus enhancing patient care in individuals at risk of or suffering from fungal infections [33]. ...