Min Li's research while affiliated with Sun Yat-Sen University and other places
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Publications (31)
Objective: We aimed to study the possible relationship between cryptococcal meningitis (CM) and HLA genotypes in HIV-negative immunocompetent patients. Methods: HLA loci of 53 HIV-negative immunocompetent Han Chinese CM patients were compared with those in 481 healthy individuals. Results: We found a significant association between DQB1*05:02 and C...
Background:
Our previous study explored Amphotericin B (AMB) plus 5-flucytosine (5-FC) combined with fluconazole (FLU) therapy in the induction period, which seemed to be better than the previous AMB + 5-FC antifungal therapy in non-HIV and non-transplant-associated CM. However, based on our clinical finding, the outcomes of some CM patients who r...
Objective
This research aims to study the correlation between serum immune factors and post-infectious inflammatory response syndrome (PIIRS) in immunocompetent cryptococcal meningitis (CM), and explore whether serum immune factors could be used to predict the development of PIIRS.
Methods
A cohort of 30 patients with PIIRS and 87 patients without...
Objectives
Metagenomic next-generation sequencing (mNGS) has been applied more and more widely for the diagnosis of infectious diseases, but its performance in the diagnosis of cryptococcal meningitis (CM) remains unclear.
Methods
Cerebrospinal fluid (CSF) samples from 197 HIV-negative patients with suspected central nervous system infections were...
Aim: The purpose of our study was to assess the differences between HIV-negative cryptococcal meningitis (CM) patients with and without autoimmune diseases. Methods: A total of 43 CM patients with autoimmune diseases and 67 without autoimmune diseases were enrolled for analysis. Results: CM patients with autoimmune diseases had higher fever, modifi...
Background
This retrospective study aimed to explore the curative effect of amphotericin B (AMB) and fluorocytosine (5-FC) combined with voriconazole (VOR) in the induction period for the treatment of non-HIV- and non-transplant-associated cryptococcal meningitis (CM).
Methods
Clinical data from patients admitted to the Third Affiliated Hospital o...
Background
Raised intracranial pressure (ICP) and insufficient antifungal regimens are the two main factors result to unsatisfactory outcomes in non-HIV cryptococcal meningitis (CM) patients. In this study, we try to discuss that whether triple therapy of amphotericin B (AmB), fluconazole, 5-flucytosine (5-FC) plus ventriculoperitoneal shunts (VPS)...
Aim: The aim of our study was to describe the characteristics of postinfectious inflammatory response syndrome (PIIRS) in HIV-uninfected and nontransplant men after cryptococcal meningitis (CM). Patients & methods: A case-control study was designed to compare HIV-uninfected and nontransplant male CM patients with and without PIIRS. Results: CM-PIIR...
Background: Raised intracranial pressure (ICP) and insufficient antifungal regimens are the two main factors result to unsatisfactory outcomes in non-HIV cryptococcal meningitis (CM) patients. In this study, we try to discuss that whether triple therapy of amphotericin B (AmB), fluconazole, 5-flucytosine (5-FC) plus ventriculoperitoneal shunts (VPS...
Background
Raised intracranial pressure (ICP) and insufficient antifungal regimens, are the two main factors result to unsatisfactory outcomes in non-HIV cryptococcal meningitis (CM) patients. In this study, we try to discuss that whether triple therapy of amphotericin B (AmB), fluconazole (Flu), 5-flucytosine (5-FC) plus ventriculoperitoneal shunt...
Background: Raised intracranial pressure (ICP) and insufficient antifungal regimens are the two main factors result to unsatisfactory outcomes in non-HIV cryptococcal meningitis (CM) patients. In this study, we try to discuss that whether triple therapy of amphotericin B (AmB), fluconazole, 5-flucytosine (5-FC) plus ventriculoperitoneal shunts (VPS...
Background: Raised intracranial pressure (ICP) and insufficient antifungal regimens are the two main factors result to unsatisfactory outcomes in non-HIV cryptococcal meningitis (CM) patients. In this study, we try to discuss that whether triple therapy of amphotericin B (AmB), fluconazole, 5-flucytosine (5-FC) plus ventriculoperitoneal shunts (VPS...
Background: Raised intracranial pressure (ICP) and insufficient antifungal regimens, are the two main factors result to unsatisfactory outcomes in non-HIV cryptococcal meningitis (CM) patients. In this study, we try to discuss that whether triple therapy of amphotericin B (AmB), fluconazole (Flu), 5-flucytosine (5-FC) plus ventriculoperitoneal shun...
CLCN2-related leukoencephalopathy (CC2L) is a rare disease due to autosomal recessive loss-of-function mutations in CLCN2 gene. We generated an induced pluripotent stem cell (iPSC) line (SKLOi001-A) from urine cells isolated from a CC2L patient carrying a homozygotic mutation: c.2257C>T (p.Arg753*) in CLCN2 gene via an integration-free methods. The...
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Cryptococcal meningitis (CM) is found to occur in immunosuppressed patients and those who are immunocompetent. This study aimed to compare the presentation and outcome of CM in patients who are human immunodeficiency virus (HIV) negative with and without immunosuppression. We reviewed 255 clinical records from patients with CM who are HIV negative....
Background:
Persistent and uncontrollable intracranial hypertension (ICH) and difficulty in reducing Cryptococcus count are severe problems in cryptococcal meningitis (CM) patients. The therapeutic effects of ventriculoperitoneal shunts (VPS) in non-HIV CM patients are not fully known, and the procedure is somewhat unusual. Here, our study offers...
Objectives
Amphotericin B plus flucytosine is the most widely used induction therapy regimen for non-HIV-infected and non-transplant patients; however, the therapeutic outcomes are unsatisfactory, especially when two antifungal drugs are at sub-therapeutic doses.
Methods
In this study of induction therapy, all non-HIV-infected, non-transplant pati...
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Background:
Wolfram syndrome (WS), caused by mutations of the Wolfram syndrome 1 (WFS1) gene on chromosome 4p16.1, is an autosomal recessive disorder characterized by diabetes insipidus (DI), neuro-psychiatric disorders, hearing deficit, and urinary tract anomalies.
Case presentation:
Here we report a 11-year-old Chinese boy who presented with v...
Induced pluripotent stem cells (iPSCs) have provided new opportunities for motor neuron disease (MND) modeling, drug screening, and cellular therapeutic development. Among the various types of iPSCs, urine-derived iPSCs have become a promising source of stem cells because they can be safely and noninvasively isolated and easily reprogrammed. Here,...
Previous research indicated the association between hepatitis B virus (HBV) infection/vaccination and the onset of demyelinating diseases. However, most of these studies were single case reports, and comprehensive data are still scarce. Here we present a comprehensive analysis of 10 patients with neuromyelitis optica spectrum disorder (NMOSD) combi...
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In recent years, anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis overlapping with demyelinating disorders has attracted more and more attention. The case is about a 52-year-old woman with anti-NMDAR encephalitis presenting acute disseminated encephalomyelitis (ADEM)-like clinical/magnetic resonance (MR) findings. Here, the authors report th...
Background:
Neuromyelitis optica spectrum disorders (NMOSD) are complicated neuroautoimmune disorders which can coexist with other organ-specific autoimmune disorders. The most frequently specific organ is the thyroid. The aim of this study is to evaluate the thyroid function of NMOSD patients and detect the difference between anti-thyroid antibod...
Background:
The associations and clinical relevance of serum lipid profiles in patients with acute transverse myelitis (ATM) are unknown. Our study aimed at investigating the status of serum lipid variables (including total cholesterol (TC), triglycerides (TGs), high/low density lipoproteins (HDL/LDL), apolipoprotein A-I (ApoA-I), apolipoprotein B...
The lower levels of serum uric acid (UA) correlated with meningitis have been reported. However, comparison of UA levels among different kinds of infections of central nervous system (CNS) and changes of UA levels before and after treatment are unknown. Our study aimed to investigate the antioxidant status of serum UA in five common types of CNS in...
Systemic lupus erythematosus (SLE) is a chronic immunologic disorder that can affect multiple organ systems and makes the patient susceptible to infection. Cryptococcal meningitis (CM) is a rare but often fatal complication of SLE.
In this study, 6 patients with CM were identified among 631 patients with SLE. The demographic, clinical, laboratory p...
The clinical characteristics and outcomes in cryptococcal meningitis (CM) have been shown to vary depending on the underlying condition. The purpose of this study was to investigate these differences in patients with and without hepatitis B virus (HBV) infection.
We performed a retrospective study at the Third Affiliated Hospital of Sun Yat-Sen Uni...
NMO and ATM are intertwined both clinically and pathologically. Apolipoprotein (apo) A-I, the main apolipoprotein of HDL, plays an important role in lipid metabolism in the cerebrospinal fluid and is known to suppress pro-inflammatory cytokines generated by activated T cells in some autoimmune diseases as an immune regulator. However, the differenc...
Bilirubin is the end product of heme catabolism and has strong antioxidant properties. Serum bilirubin levels are reported to be reduced in patients with multiple sclerosis (MS) and neuromyelitis optica (NMO). The pathophysiology of optic neuritis (ON) resembles that of MS; however, the role of endogenous bilirubin in ON is unclear. The aim of this...
Citations
... At the same time, there are still patients who fail or refuse ART treatment and continue to be at risk for CM infection [6]. Also of note is that the occurrence of CM in HIV-negative hosts has been increasing in recent years [7]. In some countries, the mortality rate of CM in HIV-negative patients even exceeds that of HIV-infected patients [8]. ...
... Qu et al. [11] reported that mNGS is more sensitive than routine pathogen testing in diagnosing paediatric haematopoietic stem cell transplantation infection and can contribute to a clinical diagnosis. The mNGS of cerebrospinal fluid samples reported by Gan et al. [17] was used as a complementary test for cryptococcal meningeal diagnosis and enabled clear differentiation between Cryptococcus gatti and Cryptococcus neoformans. This present study showed that the sensitivity of mNGS was 96.77%, the specificity was 83.33%, the positive predictive value was 96.77%, and the negative predictive value was 83.33%. ...
... heterogeneous and challenging to characterize. 5,6 Additional research demonstrates increased mortality in NHNT patients with CM compared to their counterparts with HIV or a history of organ transplant. [7][8][9] The reason for poorer outcomes in NHNT individuals is likely multifactorial, partially due to delay in diagnosis due to a lower index of clinical suspicion in patients without 'classic' risk factors. ...
... Only a few studies have been conducted on CM-PIIRS, and there is no universal diagnostic criteria or a standardized treatment protocol. We diagnosed CM-PIIRS based on abnormal deterioration of clinical symptoms, changes in cranial MRI, and variations in relevant inflammatory parameters in CSF after effective antifungal therapy (persistently negative fungal culture), after excluding active infections, tumors, and drug causes [2,12]. C. gattii utilizes the neurotransmitters (including dopamine, epinephrine, etc.) in the CSF, which contributes to the formation of melanin, protection against oxidative stress and phagocytosis, and development of CM-PIIRS [13]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/951108298096640-1603773297277_Q64/Chongliang-Luo-3.jpg)
... This should continue until the pressure returns to normal for two consecutive LPs, and symptoms of increased ICP have resolved [37•]. In patients who have consistently elevated ICP, lumbar drains and ventriculoperitoneal shunts are options where available [54][55][56][57]. These interventions can decrease both the severity of the illness and the number of deaths. ...
... Anjum et al. reported that adjunctive pulse corticosteroid taper therapy could improve clinical outcomes in 15 previously healthy patients with cryptococcal PIIRS [17]. These results are consistent with our previous observations that administration of corticosteroids was associated with lower rates of fever and better modified Rankin Score scores in cryptococcal PIIRS [20]. Corticosteroids may directly affect signal transduction pathways and exert their antiinflammatory effects by multiple mechanisms [21,22]. ...
... Two hiPSC lines carrying CLCN2 c.2257C > T homozygous nonsense mutations were derived from the patient in the study. One line, SKLOi001-A (short for M1 hiPSC), was previously reported (Chen et al. 2020), and another (M2 hiPSC) was verified using the same method. Two CLCN2 mutation-corrected hiPSC lines (R1 and R2 hiPSC) were generated from the M1 hiPSC using the CRISPR/Cas9 system. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/962826474643467-1606567128894_Q64/Zhuolin-Chen.jpg)
... In our study, 28% of patients with CM had received glucocorticoids, similar to other studies (14%-23%). 28,29 However, we did not find a direct link between glucocorticoid use and the development of CM. ...
... 2 It is unusual in immunocompetent patients, but they may account for up to one-third of all cases. 3,4 Cryptococcosis results in up to 280,000 cases and 130,000 deaths yearly, with an estimated 152,000 cases and 112,000 deaths in patients with acquired immunodeficiency syndrome. 5 Both C. neoformans and C. gatti have marked neurotropism, therefore cryptococcal meningitis (CM) is the most common clinical presentation. ...
... The efficacy of triple antifungal therapy in CM has attracted increasing attention [11]. The triple regimen of AmB (0.59 ± 0.95 mg/ kg) plus FC (67.04 ± 22.36 mg/kg) and Flu (400-800 mg/d) has been proven to be more effective than AmB (0.59 ± 0.95 mg/ kg) plus FC (64.79 ± 21.06 mg/kg) without increasing the incidence of adverse effects [119]. However, the therapeutic effect of AmB in combination with FC and Flu still be unsatisfactory in some patients, in which case other triple regimens can be considered. ...
