Mikiko Sakuraya's research while affiliated with Kitasato University and other places
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Publications (19)
Background
The appropriate extent of resection for esophagogastric junction cancer and the method of surgical approach remain controversial. This study aimed to assess the safety and outcomes of the parachute technique, which is an open transhiatal reconstruction method that facilitates stable reconstruction.
Materials and methods
The surgical out...
Comprehensive understanding prognostic relevance of distinct tumor microenvironment (TME) remained elusive in colon cancer. In this study, we performed in silico analysis of the stromal components of primary colon cancer, with a focus on the markers of cancer-associated fibroblasts (CAF) and tumor-associated endothelia (TAE), as well as immunologic...
Background:
It has been reported that weight loss or lean body mass (LBM) loss after gastrectomy for gastric cancer is associated with prognosis and nutritional support alone is insufficient to prevent LBM loss. Branched-chain amino acids (BCAA) play an important role in muscle catabolism, however their clinical effects on suppression of LBM loss...
Purpose: Gastric dilatation due to food retention after gastrectomy is a risk factor for aspiration pneumonia and a prolonged hospital stay, but there is no clear index to define gastric dilatation. In this study, we aimed to identify a clinical index associated with therapeutic intervention for gastric dilatation after gastrectomy, based on abdomi...
For patients with clinical stage (cStage) I esophageal cancer that were not indicated for endoscopic resection, esophagectomy was the standard treatment if surgery was desired. The long-term prognosis after surgical resection of cStage I esophageal cancer was 86.5% of the 5-year survival rate in the results of the JCOG0502 study. The aim of this st...
Background
Pancreas-related complications after laparoscopic gastrectomy (LG) for gastric cancer can be fatal. We developed a gastrectomy procedure with no pancreas contact to prevent such complications and herein report the surgical outcomes.Methods
We retrospectively reviewed 182 consecutive patients with gastric cancer who underwent LG at Kitasa...
Purpose: Advances in chemotherapy in unresectable advanced gastric cancer have increased clinical experience with conversion surgery, but many patients still have a poor prognosis. The purpose of this study is to investigate the long-term prognosis of conversion surgery and to identify factors associated with a poor prognosis. Materials and Methods...
Purpose
In total gastrectomy, Roux-en-Y reconstruction with esophagojejunal anastomosis has been widely used in gastrointestinal reconstruction. In the case of anastomotic leakage of RY reconstruction, esophagojejunal anastomosis should be paid attention, and esophageal fragility is considered the reason for the leakage. Here, we introduce an atrau...
Promoter DNA methylation of MutL homolog 1 (MLH1) is considered to play a causative role in microsatellite instability (MSI) carcinogenesis in primary gastric cancer, and a high MSI status is associated with treatment sensitivity to human cancers. Nevertheless, clinicopathological analysis is defective for MLH1 methylation status in a quantitative...
Background
The number of elderly patients with gastric cancer is increasing, with the very elderly often refusing radical gastrectomy with lymph node dissection. Such a patient presented to us and we proposed a palliative surgery involving gastric local resection using laparoscopy endoscopy cooperative surgery (LECS).
Case presentation
An 89-year-...
PurposePostoperative infectious complications have a negative impact on survival outcomes in patients with gastric cancer. It is recently reported that preoperative chemotherapy may eliminate this negative impact. This study aimed to confirm whether preoperative chemotherapy can eliminate the negative impact of postoperative infectious complication...
The clinical efficacy of DNA cytology test (CY) in gastric cancer (GC) has been retrospectively proposed using cancer-specific methylation of the Cysteine dioxygenase type 1 (CDO1). We confirmed its clinical utility of DNA CY in a prospective cohort. Four hundred GC samples were prospectively collected for washing cytology (UMIN000026191), and dete...
PurposeWith the widespread use of definitive chemoradiotherapy (dCRT) for esophageal squamous cell carcinoma (ESCC), salvage surgery for recurrence/residual patients became prevalent. However, survival impact of salvage surgery remains obscure at present.Methods
The updated clinical outcomes of salvage surgery were investigated to know its survival...
PurposeThe purpose of this study is to evaluate the long-term survival outcomes of KDOG1001 trial after a minimum follow-up of 3 years.Methods
Patients with bulky N2 lymph nodes, linitis plastica (type 4), or large ulcero-invasive-type tumors (type 3) received up to four 28-day cycles of DCS neoadjuvant chemotherapy (docetaxel at 40 mg/m2, cisplati...
Purpose:
Transthoracic esophagectomy for esophageal cancer is one of the most invasive procedures in surgery for gastrointestinal cancer. Serious complications sometimes occur after esophageal cancer surgery, including recurrent laryngeal nerve injury and pneumonia. The purpose of this study was to access the possibility of robot-assisted thoracos...
4521
Background: In the phase 2, open-label, KDOG1001 (UMIN000003642) study, neoadjuvant chemotherapy (NAC) with docetaxel, cisplatin, and S-1 (DCS), followed by gastrectomy with D2 lymph node dissection for high-risk advanced gastric cancer showed feasibility of DCS therapy with an enough R0 resection rate of 90%. Here we present long-term results...
Background
The optimal dose of each drug used in the docetaxel, oxaliplatin, and S-1 (DOS) chemotherapy remains to be clarified for the Japanese population. The purpose of this study was to determine a recommended dose for a combination neoadjuvant DOS chemotherapy for Japanese patients with locally advanced adenocarcinoma of the esophagogastric ju...
Background
A triple chemotherapeutic regimen including docetaxel, oxaliplatin, and S-1 (DOS) for a neoadjuvant setting has a promising efficacy for locally advanced adenocarcinoma of the esophagogastric junction (AEG). However, the optimal dose of each drug in Japanese population remained to be clarified. The aim of this phase I study is to determi...
A 27-year-old man complained of fever and abdominal pain. Computed tomography (CT) revealed a cystic tumor, exceeding 3 cm in diameter, between the inferior vena cava under the left renal vein and abdominal aorta. No definitive diagnosis of the cystic tumor was reached after positron emission tomography CT and ultrasound guided fine needle aspirati...
Citations
... We herein explored fCAFs-associated genes (fCAFGs) representing close association with the LRRC15 expression (R = 0.9 or beyond) in GSE35602 according to expression amounts (140 green color gene probes, Table S1). Among the previously identified 115 SPARC-associated CAFGs [17], 54 genes were shared with LRRC15-redefined fCAFGs ( Table 1). For example, ACTA2 and ITGA11 were removed from IRRC15-redefined fCAFG (blank box, Figure 1a) due to a low R index below 0.9 with LRRC15 (R = 0.89 and 0.88, respectively), whereas a well-known PDAC CAFs marker, FAP [25][26][27], was closely associated with IRRC15 (inlet figure of Figure 1a, R = 0.98). ...
... The median length of the resected esophagus during lower-esophagogastrectomy was 40 mm. In terms of postoperative complications, three (15%) patients developed grade II intra-abdominal uid correction according to the Clavien-Dindo classi cation [11]. However, none of the patients presented with grade III or higher complications or anastomotic leakage. ...
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... For patients with increased TPS over 11.8 mm, careful pancreatic manipulation is required. When performing the pancreas-contactless technique, the operator themself should gently perform the minimal number of necessary pancreatic compressions instead of an assistant to pay more awareness to the procedure [41]. ...
... In Japan, the current indication for LECS is gastrointestinal stromal cell tumors (GIST) with a size of 2-5 cm. LECS has also been described in two case reports as palliative treatment for patients with AGC without being in a state to undergo gastrectomy (12)(13). To the best of our knowledge, no prospective trial has studied LECS for this indication. ...
... In our previous studies, we have confirmed that complete PAC (≥ 6 cycles) could cancel out the adverse influence of a low prognostic nutritional index, low BMI, peri-operative blood transfusion and/or infections on survival in stage II or III GC patients [15][16][17]. Given that PAC could impact recurrence patterns and modify the predictive factors for survival in GC patients [22][23], we must cite the previous conclusions with caution and a new nomogram was clearly needed in patients treated incompletely with PAC. ...
... The deficiency of the cysteine dioxygenase 1 (CDO1) expression has been reported in lung [1], endometrial [2], breast [3], prostate [4], clear-cell renal cell [5], and gastrointestinal [6] cancers to date, and this aberration correlates with poor survival outcomes in patients with the examined cancer types [4,5,[7][8][9][10]. Additionally, CDO1 shows promising diagnostic value in a few tumor types; for example, it could be an efficient strategy to determine minimal residual disease of the peritoneum in patients with gastric cancer (GC) [11,12]. GC ranks the fifth for incidence and the fourth for cancer-caused mortality worldwide in 2020 [13]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1059224020865024-1629550094144_Q64/Nobuyuki-Nishizawa.jpg)
... In conventional ER for naïve cases, en block and R0 resections are required to prevent local recurrence (17). Salvage EMR was originally developed for small localized esophageal cancer lesions as an alternative to surgery because it showed similar efficacy and was less invasive than salvage esophagectomy (18)(19)(20)(21). However, it has been reported that the en block and R0 resection rates were relatively low for salvage EMR, as well as conventional EMR, when utilized for large lesions, which is consistent with our results (6)(7)(8)(22)(23)(24)(25)(26)(27). ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/278402415251484-1443387716835_Q64/Hiromichi-Ishiyama-2.jpg)
... In the present study, patients with type 4 GC had a significantly worse 5-year OS than those with non-type 4 GC. Hosoda et al. suggested that the optimal therapy for type 4 and large type 3 GCs may need to be separately developed with consideration of target molecules (8). Therefore, we need to develop a different treatment strategy for type 4 GC. ...
... The advantages of robots with tremor filtering and motion scaling can be maximized in recurrent laryngeal lymph node dissection, which requires precise manipulation. Another advantage of monopolar scissors is that they can sharply dissect without an electrical source, as traction and thermal injury can cause recurrent laryngeal nerve palsy (6). However, because of the monopolar electrode, contact with adjacent organs may cause fatal damage and complications; therefore, effective use of the articulated instrument, tremor filtering, and motion scaling to avoid contact with adjacent organs is imperative ( Figure 1). ...
... The DPD inhibitors had combined with orally bioavailable fluorinated pyrimidine such as capecitabine or tegafur to verify the similar effect to continuous intra-venous infusion of 5-FU and did not prove molecules advantageous to continuous intra-venous infusion (Kobayakawa and Kojima, 2011;Aguado et al., 2014). Furthermore, more oral fluoropyrimidine such as S1 (tegafur/gimeracil/oteracil) are in progress phase I clinical trials for tumors, including EC (Ajani et al., 2020;Hosoda et al., 2020). However, up to date, the 5-FU is still the widest used fluorinated pyrimidine for cancer treatment. ...
