Michelle Moreland's research works | Purdue University, IN (Purdue) and other places

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γ-Tocopherol attenuates moderate but not severe colitis and suppresses moderate colitis-promoted colon tumorigenesis in mice

Article

Full-text available

Sep 2013

Inflammation can promote colon cancer. Mechanistic studies indicate that γ-tocopherol (γT), a major form of vitamin E in diets, has anti-inflammatory and anticancer properties. Here we investigated the effectiveness of γT and a mixture of tocopherols against colitis and colitis-promoted colon tumorigenesis in male BALB/c mice. γT or mixed tocophero...

Gamma‐tocopherol but not mixed tocopherols attenuates moderate colon inflammation and inflammation‐promoted colon tumorigenesis in mice

Article

Apr 2012

Inflammation promotes cancer development. Gamma‐tocopherol (γT), the predominant form of vitamin E in US diets, is shown to have anti‐inflammatory activities. Here we examined anticancer efficacy of γT and a mixture of tocopherols against colon cancer which is induced by azoxymethane (AOM, 10mg/kg) and promoted by severe or moderate inflammation th...

Vitamin E forms inhibit IL-13/STAT6-induced eotaxin-3 secretion by up-regulation of PAR4, an endogenous inhibitor of atypical PKC in human lung epithelial cells

Article

Full-text available

Jul 2011

Eotaxin-3 (CCL-26), a potent chemokine for eosinophil recruitment and contributing significantly to the pathogenesis of asthma, is secreted by lung epithelial cells in response to T helper 2 cytokines including interleukin 13 (IL-13). Here we showed that vitamin E forms, but not their metabolites, differentially inhibited IL-13-stimulated generatio...

Abstract 4589: Gamma-tocopherol and mixed tocopherols inhibit AOM-induced colon carcinogenesis that was promoted by moderate but not severe colon inflammation caused by dextran sodium sulfate

Article

Apr 2011

Our previous studies indicate that specific forms of vitamin E such as gamma-tocopherol (gT), the predominant form of vitamin E in US diets, have anti-inflammatory activities by inhibition of proinflammatory eicosanoids including prostaglandin E2 and leucotriene B4. These eicosanoids are known to promote carcinogenesis of different types of cancer...

A combination of aspirin and γ-tocopherol is superior to that of aspirin and α-tocopherol in anti-inflammatory action and attenuation of aspirin-induced adverse effects

Article

Nov 2008

Nonsteroidal anti-inflammatory drugs such as aspirin are used for pain relief and chemoprevention against cancer, but frequently cause gastric mucosal injury. We examined whether combinations of aspirin and alpha-tocopherol (alphaT) or aspirin and gamma-tocopherol (gammaT), with alphaT and gammaT being the two major forms of vitamin E, are better a...

Vitamin E forms inhibited IL‐13‐induced eotaxin secretion by blocking stat6 activation in human lung epithelial A549 cells

Article

Mar 2008

Airway epithelial cells release eotaxins (CCLll, CCL24, CCL26) upon being stimulated by IL‐13, a cytokine generated from Th2 cells. Eotaxins are potent chemotactic agents for eosinophils, which play an important role in the pathogenesis of allergic airway diseases. The goal in the current study is to investigate the potential effect of vitamin E fo...

Combination of aspirin and gamma‐tocopherol is superior to aspirin alone in protection of carrageenan‐induced inflammation in a rat model

Article

Mar 2008

We examined whether combinations of aspirin and alpha‐tocopherol (aT) or gamma‐tocopherol (gT), two major forms of vitamin E, can alleviate aspirin‐caused stomach lesion and may be better anti‐inflammatories than aspirin alone. In carrageenan‐induced inflammation air‐pouch model, aspirin at 150mg/kg inhibited inflammation‐associated increase of pro...