Michael Kressel's research while affiliated with Friedrich-Alexander-University of Erlangen-Nürnberg and other places
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Publications (19)
The neurofibromatosis 2 protein merlin is a classical tumor suppressor protein. Germline mutations predispose to the development of schwannomas, meningiomas and ependymomas. Merlin has been implicated in cellular migration and adhesion. This function is reflected in its subcellular localization at the plasma membrane and known interacting partners....
Vagal mechanosensitive afferents with an important functional role in esophageal peristalsis are well known from physiological studies. It is not known whether these fibers represent a separate subpopulation among all vagal afferents projecting to the esophageal wall. A morphological and immunohistochemical description of vagal afferents was undert...
We cloned novel splice variants Mer150, Mer151 and Mer162 of the neurofibromatosis 2 (NF2) tumor suppressor, which demonstrate a tissue-specific and development-specific expression pattern. Isoform Mer150 is created by cryptic splicing from exon 8 to 14 and represents an N-terminal truncation of 259 residues. Mer151 is characterized by in-frame spl...
Anterograde tracing with the carbocyanine tracer DiI and the aminostyrol derivative DiA was used to selectively label fibers from the nucleus ambiguus, dorsal motor nucleus and nodose ganglion, respectively, terminating in the rat esophagus, and to compare them with the innervation of the gastric fundus in the same animals. Ambiguus neurons termina...
Current protocols for a combined approach of anterograde tracing with carbocyanine dyes or horseradish peroxidase (HRP) conjugates and immunohistochemistry represent a compromise between sensitive detection of the tracer and the immunohistochemical procedure. Therefore, it was investigated whether the use of tyramide amplification allows sensitive...
To elucidate the physiological function of the neurofibromatosis type 2 (NF2) tumor suppressor protein merlin/schwannomin, we studied the expression pattern and subcellular localization in human fibroblasts by Western blot analyses and immunofluorescence using a polyclonal antibody raised against the C-terminus of merlin. Three of the six merlin is...
Human T-cell acute lymphocytic leukaemia (ALL) was established in athymic nude or severe combined immunodeficient (SCID) mice by injecting CEM or MOLT-16 cells. When nude mice bearing approx. 2 g of tumour were treated with a single injection of CD7 antibody TH-69, 82.6% reached complete remission within 10 d whereas 13.0% showed partial remission....
Results from functional studies point to the importance of chemoreceptive endings in the duodenum innervated by vagal afferents in the regulation of gastrointestinal functions such as gastric emptying and acid secretion, as well as in the process of satiation. In order to visualize the vagal sensory innervation of this gut segment, vagal afferents...
Abdominal vagal afferent fibers were selectively labeled by injecting the fluorescent carbocyanine dye DiI into the left nodose ganglion of rats. Almost all paraganglia that were distributed along the five major abdominal vagal branches and their subbranches were found to be innervated by labeled vagal afferents. Laser scanning confocal microscopy...
The occurrence and spatial distribution of intracellular DNA fragmentation was investigated by in situ 3' end labelling of DNA breaks in K562 cells treated in such a way to cause either apoptotic or necrotic cell death. The localisation of DNA breaks was examined by confocal laser microscopy and compared with the electron-microscopic appearance of...
The occurrence and spatial distribution of intracellular DNA fragmentation was investigated by in situ 3′ end labelling of DNA breaks in K562 cells treated in such a way to cause either apoptotic or necrotic cell death. The localisation of DNA breaks was examined by confocal laser microscopy and compared with the electron-microscopic appearance of...
A chronic infection with the spirochaete Borrelia burgdorferi typically results in a multistage, multisystem illness. Thus, Lyme borreliosis may provide an interesting model to study the pathomechanisms of microbial persistence. In the present investigation, human peripheral blood monocytes, polymorphonuclear leukocytes, and synovial macrophages we...
In an attempt to identify the distribution and structure of vagal fibers and terminals in the gastroduodenal junction, vagal efferents were labeled in vivo by multiple injections of the fluorescent carbocyanine dye DiA into the dorsal motor nucleus (dmnX), and vagal afferents were anterogradely labeled by injections of DiI into the nodose ganglia o...
As soon there was compelling evidence that the spirochete Borrelia burgdorferi was the causative agent of Lyme disease (Burgdorfer et al. 1982), the first ultrastructural studies were performed on the non-specific cellular immune response to this pathogen. The examination of ultrathin sections with the electron microscope showed the presence of B....
In order to investigate the distribution and structure of the vagal liver innervation, abdominal vagal afferents and efferents were selectively labeled by injecting WGA-HRP or Dil into the nodose ganglia, and DiA into the dorsal motor nucleus, respectively. Vagal afferent fibers produced characteristic terminal-like structures at three locations in...
Citations
... Previous works have already demonstrated that curcumin triggers apoptosis in cancer cells [15][16][17][18], which is a common feature of ICD inducers [19,20]. As expected, F/T treatment lead almost exclusively to necrosis, as this process causes disruption of cellular membranes [21,22]. ...
... It has been described that only a limited number of vagal sensory neurons in the left nodose ganglion project to the liver in rats (13). The peripheral nerve terminals of the vagal sensory neurons innervating the liver are primarily present in the bile ducts and portal veins, whereas no afferent terminals are observed in the hepatic parenchyma of rats (14). Although the central projection sites of vagal sensory neurons innervating the liver remain unknown, the central axon terminals of vagal sensory neurons are generally localized to the nucleus of the tractus solitarius (NTS), area postrema (AP), and dorsal motor nucleus of the vagus (DMV) (15). ...
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... In particular, a number of seminal studies over the last 40 years have characterized fine morphological characteristics of the vagal afferent innervation and nerve endings in different regions of the gastrointestinal (GI) tract (Berthoud & Powley, 1992;Berthoud et al., 1990;Kressel et al., 1994;Powley & Phillips, 2011;Wang & Powley, 2000;Zagorodnyuk & Brookes, 2000;Zagorodnyuk et al., 2001). ...
... and parasympathetic nerves whose branches, through the splanchnic and vagal nerves, form two discrete perivascular plexuses in the portal region. 2,6,8,[10][11][12][13] Most of the knowledge regarding the morphological and functional features of the rat hepatic nerves comes from specific histochemical staining for neuronal markers, 10 from neuronal tracing, 12,[14][15][16] and chemical and surgical denervation. 10,[17][18][19] Thus, in the rat, as in other mammals, and humans, the liver is supplied with both efferent and afferent nerve fibers. ...
... The characteristics of vagal afferent endings we identified are similar to those reported in the Powley study (Berthoud et al., 1995;. ...
... Nevertheless, caspase activation is not necessarily an indication of the apoptosis process [30]. Therefore, other assays such as TUNEL (Terminal dUTP Nick End-Labeling) were used by enzymatically end-labeling the DNA strand breaks [30,84]. By detecting DNA fragmentation, we could show that silencing of Bax+Bak after treatment with etoposide and staurosporine resulted in a significantly reduced number of TUNEL-positive cells compared to control cells. ...
... Borrelia cell invasion has been investigated in several cell lines, such as macrophages (Rittig et al., 1992(Rittig et al., , 1994Montgomery and Malawista, 1996;Naj and Linder, 2015;Meriläinen et al., 2016;FIGURE 6 | Borrelia burgdorferi did not co-localize with lysosomes. Merged representative images of SW1353 (A,B) and BJ (C,D) cells infected with B. burgdorferi at 24 h and 9-day time points, respectively. ...
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... Thus, CD7 is considered as an attractive target for T-ALL immunotherapy [13,25]. In recent decades, studies have focused on using anti-CD7 CAR T cells or anti-CD7 antibodies to treat T-ALL [26][27][28][29][30]. However, since CD7 is also extensively expressed in normal T cells and natural killer cells, extending the success of CAR-T therapy to T cell malignancies faces challenges such as CAR-T cell fratricide, high production cost, long lagging time and potential product contaminations [30]. ...
... Most Merlin-proximal proteins in this dataset are components of either cell-cell or cell-extracellular matrix junctions, including cadherin-based adherens junctions, claudin-based tight junctions, integrin-based focal adhesion complexes, the polarity complex, and the laminin-binding dystrophin glycoprotein complex (67). These data are consistent with Merlin localization to the cell periphery (68,69) and the observation that Merlin is critical for the organization of Schwann cell contacts in peripheral nerves (16). The ability of wild-type and mutant forms of Merlin to biotinylate nearby proteins also provides insight into Merlin structure and function. ...
... Due to the ethical consideration of restricting food intake in mice a few days after surgery, these studies were only performed on SLD and HFD mice. We use the tracer WGA-HRP because WGA is widely accepted as one of the optimal anterograde tracers for filling of fine varicosity endings in vagal afferent pathways, while HRP allows for tyramide signal amplification to resolve fine anatomical structures (Kressel, 1998). ...
