Mengxing Liu's research while affiliated with Shanxi University and other places
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Publications (7)
Discrimination of cancer cells/tissues from normal ones is of critical importance for early diagnosis and treatment of cancers. Herein, we present a new strategy for high‐contrast fluorescence diagnosis of cancer cells/tissues based on β‐Lapachone (β‐Lap, an anticancer agent) triggered ROS (reactive oxygen species) amplification specific in cancer...
Based on β-Lapachone-triggered ROS amplification specific in cancer cells/tissues, a wide range of cancer cells/tissues, including surgical tissue specimens harvested from patients, were distinguished from normal ones by using a combination of β-Lap and a Si-rhodamine-based NIR fluorescent ROS probe with average tumor-to-normal (T/N) ratios up to 1...
Boron-dipyrromethenes (Bodipys), since first reported in 1968, have emerged as a fascinating class of dyes in the past few decades due to their excellent photophysical properties including bright fluorescence, narrow emission bandwidth, resistance to photobleaching, and environment insensitivity. However, typical Bodipys are highly lipophilic, whic...
To probe the regulatory roles of cysteine (Cys) in cancel cell survival, a highly selective and sensitive fluorescent Cys probe SiR was developed by employing a novel “lock and key” strategy, which allows Cys to be detected without any interference or probe consumption caused by intracellular high concentration of glutathione (GSH). Using SiR, we c...
Citations
... [6] Recently, Guo et al. reported a fluorescent probe for highcontrast diagnosis of cancer cells/tissues on the basis of βlapachone triggered ROS amplification. [7] However, the method is less effective for in situ real-time imaging of tumors in vivo. [7] In addition to insufficient differences of analyte levels, another reason resulting in low-contrast imaging is that the dyes released by the activatable probes often tend to diffuse from cancer cells/tissue to the medium or adjacent tissues due to the concentration gradient between the cellular interior and exterior. ...
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... Electron leakage during energy metabolism leads to the generation ROS and NOS [15]. Mitochondrial ROS are usually 10 times higher in tumor than in normal cells [310]. To avoid excessive oxidative damage, cancer cells activate potent cellular antioxidant systems in order to counteract ROS by superoxide dismutases (SODs) enzymes in mitochondria, catalyzing O 2 − to H 2 O 2 . ...
... We further studied the cell uptake behaviors of the two C-dots. As shown in Figures S8 and S9, for both C-dots-1 or C-dots-2, the fluorescence intensities of the incubated cells do not exhibit obvious differences at 4 and 37 °C, which implies that the cell uptake is mainly based on an energy-independent passive diffusion pathway [27]. Sequentially, the effects of several chemical inhibitors including chlorpromazine (CPZ, one of the inhibitors for clathrin-mediated endocytosis), cytoD (one of the inhibitors for micropinocytosis and phagocytosis), and nystatin (one of the inhibitors for caveolin-mediated endocytosis), were investigated [27]. ...
... Cysteine is the rate-limiting amino acid for GSH synthesis. Cells mainly exchange intracellular glutamate for extracellular cystine through System Xc at a ratio of 1:1, and then reduce the imported cystine to cysteine, thus allowing the synthesis of GSH (34). System Xc is composed of the light chain of solute carrier family 7 member 11 (SLC7A11) and the heavy chain of solute carrier family 3 member 2 (SLC3A2). ...
Reference: Ferroptosis in cancer (Review)
