Melissa Razo-Azamar's research while affiliated with Instituto Nacional de Medicina Genómica and other places
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Publications (6)
Context
Pancreatic β-cell function impairment is a key mechanism for developing gestational diabetes mellitus (GDM). Maternal and placental exosomes regulate maternal and placental responses during hyperglycemia. Studies have associated exosomal micro-RNAs (miRNAs) with GDM development. To date, no studies have been reported that evaluate the profi...
Background
Gestational diabetes mellitus (GDM) represents the main metabolic alteration during pregnancy. The available methods for diagnosing GDM identify women when the disease is established, and pancreatic beta-cell insufficiency has occurred.The present study aimed to generate an early prediction model (under 18 weeks of gestation) to identify...
Background & Aims
Overweight and obesity in reproductive-age women hasten the development of insulin resistance and increase risk for deterioration of pregnancy metabolism. These pregnancy-associated metabolic changes are similar to those of the metabolic syndrome. Thus, some metabolic flexibility must allow appropriate adaptation to the metabolic...
Gestational diabetes (GD) represents the main metabolic alteration during pregnancy affecting 17% of pregnancies in Mexico. The clinical relevance of this pathology is the short and long-term complications such as obesity, diabetes, and hypertension; that affect mother and child. GD is often diagnosed between weeks 24 to 28 of gestation through an...
Citations
... These small vesicles transport bioactive compounds like proteins, nucleic acids, and lipids 30,31 . In the specific context of pregnancy, current research highlights the significant impact of exosomes as potential mediators in maternal-fetal communication 32,33 . During pregnancy, intricate communication between maternal and fetal cells is vital for properly developing and maintaining the gestational environment. ...
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... This review revealed that many of the predictive models for this pregnancy disease derive from data acquired by instrumental techniques, such as liquid or gas chromatography coupled to mass spectrometry (LC-MS or GC-MS, respectively), nuclear magnetic resonance (NMR) spectroscopy, and polymerase chain reaction (PCR), among others [17]. More recently, new articles have been published in the context of GDM diagnosis based on the same techniques, i.e., LC-MS [18][19][20][21], GC-MS [22], NMR spectroscopy [23], and PCR [24][25][26][27]. Methods based on these techniques are very time consuming, as they require tedious sample preparation procedures or prolonged instrumental runs. ...
