Mbiapo's scientific contributions

What is this page?

This page lists the scientific contributions of an author, who either does not have a ResearchGate profile, or has not yet added these contributions to their profile.

It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.

If you're a ResearchGate member, you can follow this page to keep up with this author's work.

If you are this author, and you don't want us to display this page anymore, please let us know.

Publications (1)

Table 1 Acute toxicity study -Body weight change in rats 
Table 4 Acute toxicity study -Liver biochemical values 
Table 5 Sub-acute toxicity study -Body weight change in rats 
Table 6 Sub-acute toxicity study -Liver weights (g/100g body weight) of rats 
Table 7 Sub-acute toxicity study -Blood biochemical values 

+3

Acute and Subacute Toxicities of Hydroethanolic Extract of the Ripe Fruits of Solanum torvum Sw. (Solanaceae).
  • Article
  • Full-text available

June 2005

·

357 Reads

·

·

Etoa

·

[...]

·

Mbiapo

Acute and subacute toxicity of the hydro-ethanolic extract of the ripe fruit of Solanum torvum Sw. was studied by force-feeding albino Wistar rats following the European Community and WHO toxicity guidelines. The results of the acute toxicity study indicated the median lethal dose (LD50) as 19g/kg body weight after 48 hours of treatment, and the significant variation (P <0.05) of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), total proteins (TP), total bilirubin (TBil), and creatinine at doses of 16 -20g/kg body weight. These results also indicated significant variation of the liver alkaline phosphatase (ALP), AST, ALT, TP, glutathione (GSH), and malondialdehyde (MDA) at higher doses. The results of the subacute toxicity study showed significant variation in the body weight, but no modification (P >0.05) of blood and liver parameters compared to the control group. In both acute and subacute toxicity, histological studies revealed that there were no major pathological changes of the liver and kidneys in treated rats. The results show that this extract is not highly toxic, but consumption of higher doses beyond 16g/kg could cause liver injury. Moderate consumption of small doses up to 1g/kg twice a week for 6 weeks appeared safe.

Download
Share