Marion Tissot's research while affiliated with Université de Franche-Comté and other places

... This restorative effect and maintenance of skin stability despite extreme photo-exposure in RT could be due to its immunomodulatory properties [43] when used at adequate concentrations. Cell culture experiments showed that the combined aloe/fibroin gel extract film irradiated with gamma rays promotes the healing of skin wounds by improving cell proliferation and migration, secretion of vascular epidermal growth factor (VEGF), and prevention of cellular senescence [44]. This effect is shown in Table 2 where 9 patients of the GTA had no lesions throughout the 15 RT sessions, and only 1 patient of the GTE had no lesions. ...

... Tey include superoxide (O 2 − ), hydroxyl (HO − ), hydrogen peroxide (H 2 O 2 ), and nitric oxide (NO − ). Most biochemical reactions in the body are known to generate ROS [8], which are potent in damaging important biomolecules such as proteins, nucleic acids, and lipids if they are not scavenged by antioxidants [9]. Free radicals are well known to be involved in aging and pathogenesis of stress-related disorders such as diabetes, nephrotoxicity, hepatotoxicity, malignancy, cardiovascular disorders, infammation, and neurological disorders [10][11][12]. ...

... In melanogenesis process, Tyrosinase-Related Protein I (TRP1) and Tyrosinase-Related Protein II (TRP II) play crucial roles. Tyrosinase is an oxidase enzyme leading to melanin production from tyrosine (Wang et al. 2018). Pigmentation in skin depends on melanin production of the cutaneous melanocytes. ...

... The isolation and culture methods of fibroblasts were consistent with previous reports. 21 DDF were purchased from PELOBIOTECH GmbH, Germany. ...

... Recently, previously undescribed prenyl and geranyl specialised products were reported from Artocarpus plants with cytotoxic, cardiovascular, skin-protection properties [3][4][5]. Artocarpin, a signature compound isolated from many species of the genus Artocarpus has been widely studied [2,[6][7][8]. Previous phytochemical studies revealed diversities of specialised products such as chalcones, stilbenoids, xanthones, flavones, flavonols, flavanones, flavans, and other re-arranged flavonoids and diels-alder flavonoids products. ...

... Albeit not linked to the classical idea of aging, several dermatological disorders are associated with the gain of senescent cells. For example, senescence-related acquired pathological pigmentary alter-ation including vitiligo and melasma have been described to be associated with premature senescence of the entire skin [241,[317][318][319]. Harmed mitochondrial electron transport chain complex I activity in vitiligo cells, a high level of mitochondrial malate dehydrogenase activity, lower ATP production, and a diminished capacity to cope with stressful stimuli indicate an important role of mitochondrial defective functionality in the pathogenesis of vitiligo [320,321]. ...

... The role of fibroblasts in producing extracellular matrix (ECM)-forming agents is crucial not only as the development and maintenance of normal tissue structures, but also improvements and reshuffle in the wound healing process. 6 Fibroblast fibers are used in vitro studies as a model because fibroblasts are the primary producer of collagen in the dermis layer, especially type I collagen, to study wound healing and scar. Collagen inhibition by quercetin may modulate extracellular matrix deposition and inhibit the formation of hypertrophic scar. ...

... Additionally, biomaterials engineered with specific bioactive ligands and tunable mechanical properties are also vital in the process of tissue repair [97]. By means of intercellular adhesion, cells were capable of transmitting enduring internal as well as external mechanical forces [98,99], thereby influencing the activation of biochemical signaling pathways and downstream gene transcription [100]. For example, mechanical stretch has been shown to promote the expansion of intact skin by influencing gene regulation of skin stem cells [101]. ...