Marilyn Bulloch's research while affiliated with Auburn University and other places
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Publications (8)
Phenyl‐ γ ‐aminobutyric acid (phenibut) is an analog of the inhibitory neurotransmitter γ ‐aminobutyric acid (GABA) that was first synthesized in Russia in the early 1960s. It is marketed as a nootropic (smart drug) to improve cognitive performance, and to treat generalized and social anxiety, insomnia, and alcohol withdrawal. The use of phenibut i...
Background
Achieving therapeutic doses of sedation and analgesia are necessary for the safety and comfort of mechanically ventilated patients. Patients with complicated psychiatric histories, are neurocritical, and have acute respiratory distress syndrome usually require maximum sedation, making sedation weaning an arduous task.
Case Presentation...
Kratom (Mitragyna speciosa) consists of over 40 alkaloids with two of them, mitragynine (MG) and 7‐OH‐mitragynine (7‐OH‐MG) being the main psychoactive compounds. MG and 7‐OH‐MG each target opioid receptors and have been referred to as atypical opioids. They exert their pharmacologic effects on the μ, δ, and κ opioid receptors. In addition, they af...
Citations
... The authors uncovered hundreds of fatalities attributed to consumption of products sold in the United States and vast, complicated intricacies of the currently unregulated US trade in products claimed to be derived from the kratom plant [7][8][9]. Several comprehensive reviews of kratom alkaloids pharmacology have been recently published [10][11][12]. ...
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