Marian May's research while affiliated with University of Miami Miller School of Medicine and other places

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Publications (1)

Ability Of Paba To Protect Mammalian Skin From Ultraviolet Light-Induced Skin Tumors And Actinic Damage
  • Article

December 1975

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46 Reads

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85 Citations

Journal of Investigative Dermatology

Diane Sekura Snyder

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Marian May

Application of 5% para-aminobenzoic acid (PABA) to hairless mice one hour Prior to ultra-violet light (UVL) irradiation will almost totally protect these animals from developing tumors induced by chronic exposure to UVL in the 290 to 320 nm range in conjunction with a chemical carcinogen. Mice exposed to UVL and not protected by PABA developed primarily squamous cell carcinomas. Two months after cessation of chronic UVL exposure, the non-PABA-treated irradiated mouse skin appeared thickened, yellow, and wrinkled while showing elevated DNA synthesis, hyperplasia. hypergranulosis, and increased amounts of elastotic material. The PABA-treated skin was grossly normal.

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Citations (1)

... It was established, that vitamins of B group, incl. РАВА and betacarotene (provitamin A) and D-alpha-tocopherol (vitamin E), possess the UV-absorbing property and are widely used to protect from solar radiation, photocarcinogenic exposures and inflammatory agents [1][2][3][4][5][6][7][8][9]. Molecular and genetic mechanisms of these processes in mammalian cells are poorly understood. ...

Reference:

Vitamin Para-Aminobenzoic Acid (PABA) Controls Generation of Nitric Oxide (NO) In Vitro and its Biological Functions in the Bacterial Cells
Ability Of Paba To Protect Mammalian Skin From Ultraviolet Light-Induced Skin Tumors And Actinic Damage
  • Citing Article

  • December 1975

Journal of Investigative Dermatology

Diane Sekura Snyder

·

Marian May