Man Chu's research while affiliated with Wenzhou Medical University and other places
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Publications (14)
Background
Ovarian cancer is one of the most common gynecological malignancies due to the lack of early symptoms, early diagnosis and limited screening. Therefore, it is necessary to understand the molecular mechanism underlying the occurrence and progression of ovarian cancer and to identify a basic biomarker for the early diagnosis and clinical t...
Cervical cancer is emerging as a potential target of increased susceptibility to coronavirus disease-2019 (COVID-19), leading to compromised survival rates. Despite this critical link, efficacious anti-cervical cancer/COVID-19 interventions remain limited. Quercetin, known for its efficacy against both cancer and viral infections, holds promise as...
OIP5-AS1, a conserved lncRNA, has been reported to be involved in several biological and pathological processes, including oncogenesis. OIP5-AS1 exerts its oncogenic or antitumor functions via regulation of different miRNAs in various cancer types. In this review, we describe the dysregulation of OIP5-AS1 expression in a variety of human cancers. M...
Accumulating evidence has demonstrated that cancer stem cells (CSCs) play an essential role in tumor progression and reoccurrence and drug resistance. Multiple signaling pathways have been revealed to be critically participated in CSC development and maintenance. Emerging evidence indicates that numerous chemopreventive compounds, also known as nut...
Cervical cancer is the most common gynecologic malignancy worldwide. Methyltransferase-like 3 (METTL3) is involved in tumorigenesis; however, it is unclear whether METTL3 plays a potential role in regulating cisplatin (DDP) resistance. Therefore, the role of METTL3 in regulation of cisplatin sensitivity in cervical cancer cells was determined. Our...
Multiple studies have confirmed that programmed death ligand 1/programmed cell death ligand-1 (PD-1/PD-L1) and immune checkpoint inhibitors (ICIs) targeting PD-1/PD-L1 play pivotal roles in the treatment of numerous tumors. Patients suffering from cancer are provided hope in the form of immunotherapy. In this review, we discussed the finding that h...
A growing amount of evidence suggests that ubiquitination and deubiquitination of PD-1/PD-L1 play crucial roles in the regulation of PD-1 and PD-L1 protein stabilization and dynamics. PD-1/PD-L1 is a major coinhibitory checkpoint pathway that modulates immune escape in cancer patients, and its engagement and inhibition has significantly reshaped th...
Ionizing radiation is a conventional therapy for cancer patients, but patients often experience distant metastasis and recurrence, which lead to a poor prognosis after the implementation of this treatment. Moreover, the underlying mechanisms by which radioresistance contributes to metastatic potential is still elusive. Here, we explored the molecul...
Pancreatic cancer is one of the most common causes of cancer death in the world due to the lack of early symptoms, metastasis occurrence and chemoresistance. Therefore, early diagnosis by detection of biomarkers, blockade of metastasis, and overcoming chemoresistance are the effective strategies to improve the survival of pancreatic cancer patients...
The lysyl oxidase (LOX) family is comprised of LOX and four LOX-like proteins (LOXL1, LOXL2, LOXL3, and LOXL4), and mainly functions in the remodeling of extracellular matrix (ECM) and the cross-linking of collagen and elastic fibers. Recently, a growing body of research has demonstrated that LOX family is critically involved in the regulation of c...
The F-box protein 22 (FBXO22), one of F-box proteins, has been identified to be critically involved in carcinogenesis. FBXO22 promotes proliferation in breast cancer and lung cancer, but suppresses migration and metastasis. FBXO22 exerts oncogenetic functions via promoting the ubiquitination and degradation of its substrates, including KDM4A, KDM4B...
Background
Emerging evidence has demonstrated that SPOP functions as an oncoprotein in kidney cancer to promote tumorigenesis by ubiquitination-mediated degradation of multiple regulators of cellular proliferation and apoptosis. However, the detailed molecular mechanism underlying the oncogenic role of SPOP in kidney tumorigenesis remains elusive....
A growing amount of evidence indicates that the neuronally expressed developmentally downregulated 4 (NEDD4, also known as NEDD4-1) E3 ligase plays a critical role in a variety of cellular processes via the ubiquitination-mediated degradation of multiple substrates. The abnormal regulation of NEDD4 protein has been implicated in cancer development...
EZH2, a histone methylase, plays a critical role in the tumor progression via regulation of progenitor genes. However, the detailed molecular mechanism of EZH2 in cancer malignant progression remains unknown. Therefore, we aimed to investigate how EZH2 is regulated in human cancer. We used numerous approaches, including Co-immunoprecipitation (Co-I...
Citations
... Recent studies have shown that OIP5-AS1 is associated with the progression of a variety of cancers [29]. To determine the potential role of OIP5-AS1 in BC, we analyzed the expression levels of OIP5-AS1 in clinical BC tissues and in different human BC cell lines. ...
... Conventional chemotherapy and stem cell transplantation have augmented the survival of patients with AML, multiple myeloma, and other haematological malignancies, but additional therapeutic strategies are needed [161][162][163]. Cancer stem cells are a logical target for novel drugs and the modulation of oncogenic cell signalling, and metabolic alterations in stem cells have attracted special attention [161,[164][165][166]. The Wnt, Hedgehog, NF-κB, and Notch signalling routes play critical roles in the differentiation, proliferation, and survival of cancer stem cells [167,168], so various compounds have been developed targeting these pathways specifically. ...
... Several studies have elucidated the important role of m6A-associated proteins in CC development. METTL3 is overexpressed in CC and silencing of METTL3 can reduce cancer cell viability, promote apoptosis and increase cisplatin sensitivity [30]. METTL14 expression is upregulated in CC, and knocking down METTL14 significantly inhibited tumor growth and invasion [31]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/427226811375617-1478870217307_Q64/Xueqiong-Zhu-2.jpg)
... Anti-PD-1/PD-L1 inhibitors: In the treatment of PD-1/PD-L1 positive aPCa patients, PD-1/PD-L1 inhibitors have shown promising results [106]. One of these inhibitors is pembrolizumab, a humanized anti-PD-1 monoclonal antibody. ...
... In this context, the cytotoxic effect of T cells plays a crucial role in eliminating cancer cells [72]. T cells, through their T cell receptors and specific binding to the major histocompatibility complex, and relying on the fine regulation of costimulatory or inhibitory signals, specifically identify and eliminate abnormal cells, including pathogens and cancer cells, which is crucial for maintaining the internal homeostasis of the human body [73]. Within this process, PD-1 serves as an important immune checkpoint receptor on T cells and exerts immunosuppressive functions in the tumor microenvironment by interacting with its ligands PD-L1 and PD-L2. ...
... Flow cytometry, MTT and colony formation assays as well as transwell and wound healing assays also demonstrated that the cell cycle regulation, cell proliferation and migration affected by ACAT1 knockdown or overexpression can be reversed by SC79 or MK2206. RNA-seq heatmap analysis and qRT-PCR validation confirmed the downregulation of c-Myc downstream molecules in ACAT1 knockdown BLCA cells, linking these molecules to cell cycle regulation and proliferation in various malignancies, including glioblastoma [52,53], nasopharyngeal carcinoma [54], esophageal cancer [55], breast cancer [56,57], cervical cancer [58], lung cancer [59], liver cancer [60][61][62], bladder cancer [63], prostate cancer [64], acute myeloid leukemia [65] and diffuse large B-cell lymphoma [66]. In addition, reports on c-Myc-regulated downstream molecules involved in EMT, such as POLD2 [52], TMEM97 [56], DCTPP1 [64], MCM6 [61] and CBX3 [53], have been published. ...
... Over the past decade, RNAs (LncRNAs) have been found to occupy a significant proportion of the human genome [9]. Accumulating evidence have suggested that lncRNAs constitute a regulatory system, participating in various cellular processes of tumors [10,11]. LncRNAs can interact with RNAs, proteins and DNA through different molecular mechanisms such as signallings, decoys, guides, scaffolds and miRNA sponges to induce tumor biological behaviors at the transcriptional levels [12,13]. ...
... First, FBXO22 has a well-established role in carcinogenesis and its expression is associated with poor survival in several cancer types 51 . While it is broadly expressed in most tissues, reports of increased levels of expression in certain cancer types, such as lung adenocarcinoma or ovarian cancers, might enable increased degradation efficiencies specifically in malignant cells, which could result in an expanded therapeutic index 52,53 . ...
... 21,22 Moreover, LOXL2 significantly affects numerous fibrotic diseases and tumors. [23][24][25] Recent studies have indicated that LOXL2 can epigenetically regulate angiogenesis by deaminating trimethylated lysine 4 of histone H3 (H3K4me3) and subsequently activating transcription. 26,27 Our analysis of sequencing data obtained from ossified (OPLL) and para-ossified (non-OPLL) ligament samples revealed an upregulation of genes and signaling pathways associated with vasculogenesis and angiogenesis in ossified tissues. ...
... However, SPOP might also play a role in promoting cancer. It was reported that SPOP could promote the epithelialmesenchymal transition of kidney, epithelial-mesenchymal transition in renal cancer epithelial cells, and promote the development of renal cancer [17]. The role of SPOP in HCC is rarely studied, only Huang's team reported that SPOP can inhibit the proliferation of HCC cells and suppress the metastasis and mesenchymalization of HCC cells by downregulating the mRNA transcription level of Zeb2 [18]. ...
