Magdalini Mischopoulou's research while affiliated with Mayo Clinic - Rochester and other places
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Publications (8)
Muscularis macrophages are a newly discovered population of macrophages distributed within the smooth muscle layers of the gastrointestinal tract. Muscularis macrophages are emerging as essential cell keepers of homeostatic gastrointestinal function, and when affected, can lead to functional gastrointestinal disorders. In this chapter, we briefly i...
The gut contains the largest macrophage pool in the body, with populations of macrophages residing in the mucosa and muscularis propria of the gastrointestinal (GI) tract. Muscularis macrophages, which are located within the muscularis propria, interact with cells essential for GI function, such as interstitial cells of Cajal (ICC)¹⁻⁴, enteric neur...
Background and Aim
Muscularis macrophages (MMs) not only mediate the innate immunity, but also functionally interact with cells important for gastrointestinal motility. The aim of this study was to determine the spatial relationship and types of contacts between the MMs and neighboring cells in the muscularis propria of human and mouse stomach, sma...
Citations
... intestinal rhythmicity. 46,48 Impaired fundic accommodation, antral hypomotility, and gastric dysrhythmias are commonly associated with diabetic gastroparesis, gastric surgery, or obesity, 49 highlighting the relevance of the complementary analysis of frequency, amplitude, and half-bandwidth of gastric contractions on the obese-related outcomes. ...
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... Additionally, it is of paramount importance to uncover the role of miR-10b-5p in other cells essential to proper gut function and maintenance, such as neurons, PDGFRα cells, smooth muscle cells, etc. [55][56][57][58][59][60] Furthermore, the leaky gut phenotype should be assessed using an Ussing chamber, which is currently the gold standard for measuring epithelial barrier permeability. Moreover, the validation of the leaky gut phenotype should be conducted using a larger number of patients. ...
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